Air pollution and retinal vessel diameter and blood pressure in school-aged children in a region impacted by residential biomass burning

Abstract Little is known about the early-life cardiovascular health impacts of fine particulate air pollution (PM2.5) and oxidant gases. A repeated-measures panel study was used to evaluate associations between outdoor PM2.5 and the combined oxidant capacity of O3 and NO2 (using a redox-weighted ave...

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Autores principales:	Jill Korsiak, Kay-Lynne Perepeluk, Nicholas G. Peterson, Ryan Kulka, Scott Weichenthal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e69bbcf001164552a43f68824af45297
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spelling	oai:doaj.org-article:e69bbcf001164552a43f68824af452972021-12-02T17:41:30ZAir pollution and retinal vessel diameter and blood pressure in school-aged children in a region impacted by residential biomass burning10.1038/s41598-021-92269-x2045-2322https://doaj.org/article/e69bbcf001164552a43f68824af452972021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92269-xhttps://doaj.org/toc/2045-2322Abstract Little is known about the early-life cardiovascular health impacts of fine particulate air pollution (PM2.5) and oxidant gases. A repeated-measures panel study was used to evaluate associations between outdoor PM2.5 and the combined oxidant capacity of O3 and NO2 (using a redox-weighted average, Ox) and retinal vessel diameter and blood pressure in children living in a region impacted by residential biomass burning. A median of 6 retinal vessel and blood pressure measurements were collected from 64 children (ages 4–12 years), for a total of 344 retinal measurements and 432 blood pressure measurements. Linear mixed-effect models were used to estimate associations between PM2.5 or Ox (same-day, 3-day, 7-day, and 21-day means) and retinal vessel diameter and blood pressure. Interactions between PM2.5 and Ox were also examined. Ox was inversely associated with retinal arteriolar diameter; the strongest association was observed for 7-day mean exposures, where each 10 ppb increase in Ox was associated with a 2.63 μm (95% CI − 4.63, − 0.63) decrease in arteriolar diameter. Moreover, Ox modified associations between PM2.5 and arteriolar diameter, with weak inverse associations observed between PM2.5 and arteriolar diameter only at higher concentrations of Ox. Our results suggest that outdoor air pollution impacts the retinal microvasculature of children and interactions between PM2.5 and Ox may play an important role in determining the magnitude and direction of these associations.Jill KorsiakKay-Lynne PerepelukNicholas G. PetersonRyan KulkaScott WeichenthalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jill Korsiak Kay-Lynne Perepeluk Nicholas G. Peterson Ryan Kulka Scott Weichenthal Air pollution and retinal vessel diameter and blood pressure in school-aged children in a region impacted by residential biomass burning
description	Abstract Little is known about the early-life cardiovascular health impacts of fine particulate air pollution (PM2.5) and oxidant gases. A repeated-measures panel study was used to evaluate associations between outdoor PM2.5 and the combined oxidant capacity of O3 and NO2 (using a redox-weighted average, Ox) and retinal vessel diameter and blood pressure in children living in a region impacted by residential biomass burning. A median of 6 retinal vessel and blood pressure measurements were collected from 64 children (ages 4–12 years), for a total of 344 retinal measurements and 432 blood pressure measurements. Linear mixed-effect models were used to estimate associations between PM2.5 or Ox (same-day, 3-day, 7-day, and 21-day means) and retinal vessel diameter and blood pressure. Interactions between PM2.5 and Ox were also examined. Ox was inversely associated with retinal arteriolar diameter; the strongest association was observed for 7-day mean exposures, where each 10 ppb increase in Ox was associated with a 2.63 μm (95% CI − 4.63, − 0.63) decrease in arteriolar diameter. Moreover, Ox modified associations between PM2.5 and arteriolar diameter, with weak inverse associations observed between PM2.5 and arteriolar diameter only at higher concentrations of Ox. Our results suggest that outdoor air pollution impacts the retinal microvasculature of children and interactions between PM2.5 and Ox may play an important role in determining the magnitude and direction of these associations.
format	article
author	Jill Korsiak Kay-Lynne Perepeluk Nicholas G. Peterson Ryan Kulka Scott Weichenthal
author_facet	Jill Korsiak Kay-Lynne Perepeluk Nicholas G. Peterson Ryan Kulka Scott Weichenthal
author_sort	Jill Korsiak
title	Air pollution and retinal vessel diameter and blood pressure in school-aged children in a region impacted by residential biomass burning
title_short	Air pollution and retinal vessel diameter and blood pressure in school-aged children in a region impacted by residential biomass burning
title_full	Air pollution and retinal vessel diameter and blood pressure in school-aged children in a region impacted by residential biomass burning
title_fullStr	Air pollution and retinal vessel diameter and blood pressure in school-aged children in a region impacted by residential biomass burning
title_full_unstemmed	Air pollution and retinal vessel diameter and blood pressure in school-aged children in a region impacted by residential biomass burning
title_sort	air pollution and retinal vessel diameter and blood pressure in school-aged children in a region impacted by residential biomass burning
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e69bbcf001164552a43f68824af45297
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Air pollution and retinal vessel diameter and blood pressure in school-aged children in a region impacted by residential biomass burning

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