Pressure ulcers microbiota dynamics and wound evolution
Abstract Bacterial species and their role in delaying the healing of pressure ulcers (PU) in spinal cord injury (SCI) patients have not been well described. This pilot study aimed to characterise the evolution of the cutaneous microbiota of PU in SCI cohort. Twenty-four patients with SCI from a Fren...
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2021
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oai:doaj.org-article:e69cfd96c962447693d37c0e170eef872021-12-02T17:24:11ZPressure ulcers microbiota dynamics and wound evolution10.1038/s41598-021-98073-x2045-2322https://doaj.org/article/e69cfd96c962447693d37c0e170eef872021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98073-xhttps://doaj.org/toc/2045-2322Abstract Bacterial species and their role in delaying the healing of pressure ulcers (PU) in spinal cord injury (SCI) patients have not been well described. This pilot study aimed to characterise the evolution of the cutaneous microbiota of PU in SCI cohort. Twenty-four patients with SCI from a French neurological rehabilitation centre were prospectively included. PU tissue biopsies were performed at baseline (D0) and 28 days (D28) and analysed using 16S rRNA gene-based sequencing analysis of the V3–V4 region. At D0, if the overall relative abundance of genus highlighted a large proportion of Staphylococcus, Anaerococcus and Finegoldia had a significantly higher relative abundance in wounds that stagnated or worsened in comparison with those improved at D28 (3.74% vs 0.05%; p = 0.015 and 11.02% versus 0.16%; p = 0.023, respectively). At D28, Proteus and Morganella genera were only present in stagnated or worsened wounds with respectively 0.02% (p = 0.003) and 0.01% (p = 0.02). Moreover, Proteus, Morganella, Anaerococcus and Peptoniphilus were associated within the same cluster, co-isolated from biopsies that had a poor evolution. This pathogroup could be a marker of wound degradation and Proteus could represent a promising target in PU management.Catherine Dunyach-RemyFlorian SalipanteJean-Philippe LavigneMaxime BrunaudChristophe DematteiAlex Yahiaoui-MartinezSophie BastideClaire PalayerAlbert SottoAnthony GélisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
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Medicine R Science Q Catherine Dunyach-Remy Florian Salipante Jean-Philippe Lavigne Maxime Brunaud Christophe Demattei Alex Yahiaoui-Martinez Sophie Bastide Claire Palayer Albert Sotto Anthony Gélis Pressure ulcers microbiota dynamics and wound evolution |
| description |
Abstract Bacterial species and their role in delaying the healing of pressure ulcers (PU) in spinal cord injury (SCI) patients have not been well described. This pilot study aimed to characterise the evolution of the cutaneous microbiota of PU in SCI cohort. Twenty-four patients with SCI from a French neurological rehabilitation centre were prospectively included. PU tissue biopsies were performed at baseline (D0) and 28 days (D28) and analysed using 16S rRNA gene-based sequencing analysis of the V3–V4 region. At D0, if the overall relative abundance of genus highlighted a large proportion of Staphylococcus, Anaerococcus and Finegoldia had a significantly higher relative abundance in wounds that stagnated or worsened in comparison with those improved at D28 (3.74% vs 0.05%; p = 0.015 and 11.02% versus 0.16%; p = 0.023, respectively). At D28, Proteus and Morganella genera were only present in stagnated or worsened wounds with respectively 0.02% (p = 0.003) and 0.01% (p = 0.02). Moreover, Proteus, Morganella, Anaerococcus and Peptoniphilus were associated within the same cluster, co-isolated from biopsies that had a poor evolution. This pathogroup could be a marker of wound degradation and Proteus could represent a promising target in PU management. |
| format |
article |
| author |
Catherine Dunyach-Remy Florian Salipante Jean-Philippe Lavigne Maxime Brunaud Christophe Demattei Alex Yahiaoui-Martinez Sophie Bastide Claire Palayer Albert Sotto Anthony Gélis |
| author_facet |
Catherine Dunyach-Remy Florian Salipante Jean-Philippe Lavigne Maxime Brunaud Christophe Demattei Alex Yahiaoui-Martinez Sophie Bastide Claire Palayer Albert Sotto Anthony Gélis |
| author_sort |
Catherine Dunyach-Remy |
| title |
Pressure ulcers microbiota dynamics and wound evolution |
| title_short |
Pressure ulcers microbiota dynamics and wound evolution |
| title_full |
Pressure ulcers microbiota dynamics and wound evolution |
| title_fullStr |
Pressure ulcers microbiota dynamics and wound evolution |
| title_full_unstemmed |
Pressure ulcers microbiota dynamics and wound evolution |
| title_sort |
pressure ulcers microbiota dynamics and wound evolution |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/e69cfd96c962447693d37c0e170eef87 |
| work_keys_str_mv |
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