Improved genetic prediction of complex traits from individual-level data or summary statistics

Existing genetic prediction tools typically assume that genetic variants contribute equally towards the phenotype. The authors develop eight prediction tools that allow the user to specify the heritability model, and show that these tools enable substantially improved prediction of complex traits.

Guardado en:

Detalles Bibliográficos
Autores principales:	Qianqian Zhang, Florian Privé, Bjarni Vilhjálmsson, Doug Speed
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6a0de6c6c764b68a43c1149c37ff7d3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e6a0de6c6c764b68a43c1149c37ff7d3
record_format	dspace
spelling	oai:doaj.org-article:e6a0de6c6c764b68a43c1149c37ff7d32021-12-02T15:23:10ZImproved genetic prediction of complex traits from individual-level data or summary statistics10.1038/s41467-021-24485-y2041-1723https://doaj.org/article/e6a0de6c6c764b68a43c1149c37ff7d32021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24485-yhttps://doaj.org/toc/2041-1723Existing genetic prediction tools typically assume that genetic variants contribute equally towards the phenotype. The authors develop eight prediction tools that allow the user to specify the heritability model, and show that these tools enable substantially improved prediction of complex traits.Qianqian ZhangFlorian PrivéBjarni VilhjálmssonDoug SpeedNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qianqian Zhang Florian Privé Bjarni Vilhjálmsson Doug Speed Improved genetic prediction of complex traits from individual-level data or summary statistics
description	Existing genetic prediction tools typically assume that genetic variants contribute equally towards the phenotype. The authors develop eight prediction tools that allow the user to specify the heritability model, and show that these tools enable substantially improved prediction of complex traits.
format	article
author	Qianqian Zhang Florian Privé Bjarni Vilhjálmsson Doug Speed
author_facet	Qianqian Zhang Florian Privé Bjarni Vilhjálmsson Doug Speed
author_sort	Qianqian Zhang
title	Improved genetic prediction of complex traits from individual-level data or summary statistics
title_short	Improved genetic prediction of complex traits from individual-level data or summary statistics
title_full	Improved genetic prediction of complex traits from individual-level data or summary statistics
title_fullStr	Improved genetic prediction of complex traits from individual-level data or summary statistics
title_full_unstemmed	Improved genetic prediction of complex traits from individual-level data or summary statistics
title_sort	improved genetic prediction of complex traits from individual-level data or summary statistics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e6a0de6c6c764b68a43c1149c37ff7d3
work_keys_str_mv	AT qianqianzhang improvedgeneticpredictionofcomplextraitsfromindividualleveldataorsummarystatistics AT florianprive improvedgeneticpredictionofcomplextraitsfromindividualleveldataorsummarystatistics AT bjarnivilhjalmsson improvedgeneticpredictionofcomplextraitsfromindividualleveldataorsummarystatistics AT dougspeed improvedgeneticpredictionofcomplextraitsfromindividualleveldataorsummarystatistics
_version_	1718387299656400896

Improved genetic prediction of complex traits from individual-level data or summary statistics

Ejemplares similares