Spindle cell variant of medullary thyroid carcinoma: a clinicopathologic study of four cases

Abstract Background Medullary thyroid carcinoma (MTC) is a malignant tumor derived from C cells. It accounts for about 10% of all thyroid malignancies. More than 14 histological variants have been described. Among them, spindle cell variant is extremely rare. Case presentation Here we describe 4 cas...

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Autores principales:	Yan Xia Wang, Shou Jing Yang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Spindle cell Thyroid carcinoma Morphology Immunophenotype Pathology RB1-214
Acceso en línea:	https://doaj.org/article/e6a3cfe716de43e3b236e4d2ef029f93
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spelling	oai:doaj.org-article:e6a3cfe716de43e3b236e4d2ef029f932021-11-28T12:37:06ZSpindle cell variant of medullary thyroid carcinoma: a clinicopathologic study of four cases10.1186/s13000-021-01152-w1746-1596https://doaj.org/article/e6a3cfe716de43e3b236e4d2ef029f932021-11-01T00:00:00Zhttps://doi.org/10.1186/s13000-021-01152-whttps://doaj.org/toc/1746-1596Abstract Background Medullary thyroid carcinoma (MTC) is a malignant tumor derived from C cells. It accounts for about 10% of all thyroid malignancies. More than 14 histological variants have been described. Among them, spindle cell variant is extremely rare. Case presentation Here we describe 4 cases of spindle cell variant of MTC collected from 2012 to 2019. Ultrasound showed solid and hypoechoic nodules. Three patients underwent total thyroidectomy and regional lymph node dissection, and 1 patient underwent thyroid mass resection. Histologically, the tumors showed spindle shaped cells in bundles or interlaced arrangement, separated by hyalinised fibrous stroma that contained amyloid deposits. Immunohistochemistry showed that the tumor cells were positive for calcitonin, chromogranin A, synaptophysin, CD56, and TTF-1, but negative for other lineage-specific markers. Conclusions We report 4 rare cases of spindle cell variant of MTC. Due to its rarity and special morphology, the diagnosis of spindle cell variant MTC relies on its morphology and immunohistochemical markers to avoid misdiagnosis.Yan Xia WangShou Jing YangBMCarticleSpindle cellThyroid carcinomaMorphologyImmunophenotypePathologyRB1-214ENDiagnostic Pathology, Vol 16, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Spindle cell Thyroid carcinoma Morphology Immunophenotype Pathology RB1-214
spellingShingle	Spindle cell Thyroid carcinoma Morphology Immunophenotype Pathology RB1-214 Yan Xia Wang Shou Jing Yang Spindle cell variant of medullary thyroid carcinoma: a clinicopathologic study of four cases
description	Abstract Background Medullary thyroid carcinoma (MTC) is a malignant tumor derived from C cells. It accounts for about 10% of all thyroid malignancies. More than 14 histological variants have been described. Among them, spindle cell variant is extremely rare. Case presentation Here we describe 4 cases of spindle cell variant of MTC collected from 2012 to 2019. Ultrasound showed solid and hypoechoic nodules. Three patients underwent total thyroidectomy and regional lymph node dissection, and 1 patient underwent thyroid mass resection. Histologically, the tumors showed spindle shaped cells in bundles or interlaced arrangement, separated by hyalinised fibrous stroma that contained amyloid deposits. Immunohistochemistry showed that the tumor cells were positive for calcitonin, chromogranin A, synaptophysin, CD56, and TTF-1, but negative for other lineage-specific markers. Conclusions We report 4 rare cases of spindle cell variant of MTC. Due to its rarity and special morphology, the diagnosis of spindle cell variant MTC relies on its morphology and immunohistochemical markers to avoid misdiagnosis.
format	article
author	Yan Xia Wang Shou Jing Yang
author_facet	Yan Xia Wang Shou Jing Yang
author_sort	Yan Xia Wang
title	Spindle cell variant of medullary thyroid carcinoma: a clinicopathologic study of four cases
title_short	Spindle cell variant of medullary thyroid carcinoma: a clinicopathologic study of four cases
title_full	Spindle cell variant of medullary thyroid carcinoma: a clinicopathologic study of four cases
title_fullStr	Spindle cell variant of medullary thyroid carcinoma: a clinicopathologic study of four cases
title_full_unstemmed	Spindle cell variant of medullary thyroid carcinoma: a clinicopathologic study of four cases
title_sort	spindle cell variant of medullary thyroid carcinoma: a clinicopathologic study of four cases
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e6a3cfe716de43e3b236e4d2ef029f93
work_keys_str_mv	AT yanxiawang spindlecellvariantofmedullarythyroidcarcinomaaclinicopathologicstudyoffourcases AT shoujingyang spindlecellvariantofmedullarythyroidcarcinomaaclinicopathologicstudyoffourcases
_version_	1718407927219355648

Spindle cell variant of medullary thyroid carcinoma: a clinicopathologic study of four cases

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