Assessment of correlation of oxidative stress and insulin resistance with glucose-6-phosphate dehydrogenase activity in Type II diabetes mellitus patients
Background: The present study aimed to assess the correlation of oxidative stress glucose-6-phosphate dehydrogenase (G6PD) activity in type II diabetes mellitus (DM) patients. Methodology: Forty-eight type II DM patients and healthy subjects were recruited. In all, G6PD activity, protein carbonyl, a...
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Wolters Kluwer Medknow Publications
2021
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oai:doaj.org-article:e6a47cd73702430eb134b81b40ca03a52021-11-19T12:15:53ZAssessment of correlation of oxidative stress and insulin resistance with glucose-6-phosphate dehydrogenase activity in Type II diabetes mellitus patients0975-740610.4103/jpbs.jpbs_291_21https://doaj.org/article/e6a47cd73702430eb134b81b40ca03a52021-01-01T00:00:00Zhttp://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=1573;epage=1576;aulast=Singhhttps://doaj.org/toc/0975-7406Background: The present study aimed to assess the correlation of oxidative stress glucose-6-phosphate dehydrogenase (G6PD) activity in type II diabetes mellitus (DM) patients. Methodology: Forty-eight type II DM patients and healthy subjects were recruited. In all, G6PD activity, protein carbonyl, and total thiol levels were measured. Results: The mean glycated hemoglobin (HbA1c) was 9.4% in Group I and 5.2% in Group II, G6PD activity was 6.5 U/gHb in Group I and 8.2 U/gHb in Group II, protein carbonyl was 14.2 nmol/mg protein in Group I and 3.5 nmol/mg protein in Group II, and total thiol level was 204.7 μmol/mL in Group I and 318.2 μmol/mL in Group II. In Group I, G6PD activity positively correlated with total thiol (r = 0.62) and negatively correlated with protein carbonyl (r = −0.73) and HbA1C (r = −0.67), protein carbonyl positively correlated with HbA1C (r =0.45) and negatively correlated with total thiol (r = −0.84), and total thiol negatively correlated with HbA1c (r = −0.30). Conclusion: G6PD may be considered a biomarker of oxidative stress and poor glycemic control in diabetic patients.Beena SinghShweta KumariWolters Kluwer Medknow Publicationsarticlediabetesglucose-6-phosphate dehydrogenaseoxidative stressPharmacy and materia medicaRS1-441Analytical chemistryQD71-142ENJournal of Pharmacy and Bioallied Sciences, Vol 13, Iss 6, Pp 1573-1576 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
diabetes glucose-6-phosphate dehydrogenase oxidative stress Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142 |
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diabetes glucose-6-phosphate dehydrogenase oxidative stress Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142 Beena Singh Shweta Kumari Assessment of correlation of oxidative stress and insulin resistance with glucose-6-phosphate dehydrogenase activity in Type II diabetes mellitus patients |
| description |
Background: The present study aimed to assess the correlation of oxidative stress glucose-6-phosphate dehydrogenase (G6PD) activity in type II diabetes mellitus (DM) patients. Methodology: Forty-eight type II DM patients and healthy subjects were recruited. In all, G6PD activity, protein carbonyl, and total thiol levels were measured. Results: The mean glycated hemoglobin (HbA1c) was 9.4% in Group I and 5.2% in Group II, G6PD activity was 6.5 U/gHb in Group I and 8.2 U/gHb in Group II, protein carbonyl was 14.2 nmol/mg protein in Group I and 3.5 nmol/mg protein in Group II, and total thiol level was 204.7 μmol/mL in Group I and 318.2 μmol/mL in Group II. In Group I, G6PD activity positively correlated with total thiol (r = 0.62) and negatively correlated with protein carbonyl (r = −0.73) and HbA1C (r = −0.67), protein carbonyl positively correlated with HbA1C (r =0.45) and negatively correlated with total thiol (r = −0.84), and total thiol negatively correlated with HbA1c (r = −0.30). Conclusion: G6PD may be considered a biomarker of oxidative stress and poor glycemic control in diabetic patients. |
| format |
article |
| author |
Beena Singh Shweta Kumari |
| author_facet |
Beena Singh Shweta Kumari |
| author_sort |
Beena Singh |
| title |
Assessment of correlation of oxidative stress and insulin resistance with glucose-6-phosphate dehydrogenase activity in Type II diabetes mellitus patients |
| title_short |
Assessment of correlation of oxidative stress and insulin resistance with glucose-6-phosphate dehydrogenase activity in Type II diabetes mellitus patients |
| title_full |
Assessment of correlation of oxidative stress and insulin resistance with glucose-6-phosphate dehydrogenase activity in Type II diabetes mellitus patients |
| title_fullStr |
Assessment of correlation of oxidative stress and insulin resistance with glucose-6-phosphate dehydrogenase activity in Type II diabetes mellitus patients |
| title_full_unstemmed |
Assessment of correlation of oxidative stress and insulin resistance with glucose-6-phosphate dehydrogenase activity in Type II diabetes mellitus patients |
| title_sort |
assessment of correlation of oxidative stress and insulin resistance with glucose-6-phosphate dehydrogenase activity in type ii diabetes mellitus patients |
| publisher |
Wolters Kluwer Medknow Publications |
| publishDate |
2021 |
| url |
https://doaj.org/article/e6a47cd73702430eb134b81b40ca03a5 |
| work_keys_str_mv |
AT beenasingh assessmentofcorrelationofoxidativestressandinsulinresistancewithglucose6phosphatedehydrogenaseactivityintypeiidiabetesmellituspatients AT shwetakumari assessmentofcorrelationofoxidativestressandinsulinresistancewithglucose6phosphatedehydrogenaseactivityintypeiidiabetesmellituspatients |
| _version_ |
1718420165792628736 |