Evaluation of corneal optical properties in subjects wearing hydrogel etafilcon A contact lenses and the effect of administering mannitol-enriched sodium hyaluronate ophthalmic solution

Evaluation of corneal optical properties in subjects wearing hydrogel etafilcon A contact lenses and the effect of administering mannitol-enriched sodium hyaluronate ophthalmic solution

Marco Lombardo,1,2 Marianna Rosati,1 Marco Pileri,3 Domenico Schiano-Lomoriello,1 Sebastiano Serrao11Fondazione G.B. Bietti IRCCS, 2Vision Engineering Italy Srl, 3Azienda Ospedaliera San Giovanni-Addolorata, Rome, ItalyBackground: The purpose of this study was to evaluate the effect of daily admini...

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Autores principales: Lombardo M, Rosati M, Pileri M, Schiano-Lomoriello D, Serrao S
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2014
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Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/e6a53ff6c851473ea7b0884e9458ba59
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spelling oai:doaj.org-article:e6a53ff6c851473ea7b0884e9458ba592021-12-02T07:31:37ZEvaluation of corneal optical properties in subjects wearing hydrogel etafilcon A contact lenses and the effect of administering mannitol-enriched sodium hyaluronate ophthalmic solution1177-5483https://doaj.org/article/e6a53ff6c851473ea7b0884e9458ba592014-11-01T00:00:00Zhttp://www.dovepress.com/evaluation-of-corneal-optical-properties-innbspsubjects-wearing-hydrog-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Marco Lombardo,1,2 Marianna Rosati,1 Marco Pileri,3 Domenico Schiano-Lomoriello,1 Sebastiano Serrao11Fondazione G.B. Bietti IRCCS, 2Vision Engineering Italy Srl, 3Azienda Ospedaliera San Giovanni-Addolorata, Rome, ItalyBackground: The purpose of this study was to evaluate the effect of daily administration of mannitol-enriched sodium hyaluronate ophthalmic solution on the corneal optical properties of subjects wearing low Dk hydrogel (etafilcon A) contact lenses (CLs).Methods: Forty-five subjects wearing etafilcon A CLs daily for more than 6 months were recruited into this pilot study. Fifteen of the subjects administered a 10% mannitol-enriched 0.05% sodium hyaluronate solution (study group) once daily and 30 subjects did not administer any ophthalmic solution (control group). The subjects were examined at baseline and one month after recruitment. Changes in central corneal thickness (CCT) and corneal light backscatter were evaluated by Scheimpflug imaging (Pentacam HR). Changes in corneal total high-order aberration, corneal spherical aberration, coma, and trefoil were evaluated using the OPD scan II.Results: At one month, corneal light backscatter decreased significantly in the study group (≤18.30 arbitrary units; P<0.05) and this was highly correlated with a decrease in CCT (R=0.81; P=0.04). The decrease in corneal total high-order aberration, spherical aberration, and coma was significantly higher in the study group than in the control group (P<0.05). No changes in corneal light backscatter or CCT were found in the control group during follow-up.Conclusion: Once-daily administration of a mannitol-enriched lubricant ophthalmic solution was effective for improving the corneal optical quality and reducing corneal swelling in subjects wearing low Dk hydrogel (etafilcon A) CLs during one month follow-up.Keywords: corneal optical quality, corneal high-order aberrations, Scheimpflug imaging, corneal backscattering, contact lens, hypertonic lubricant solutionLombardo MRosati MPileri MSchiano-Lomoriello DSerrao SDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 2347-2354 (2014)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Lombardo M
Rosati M
Pileri M
Schiano-Lomoriello D
Serrao S
Evaluation of corneal optical properties in subjects wearing hydrogel etafilcon A contact lenses and the effect of administering mannitol-enriched sodium hyaluronate ophthalmic solution
description Marco Lombardo,1,2 Marianna Rosati,1 Marco Pileri,3 Domenico Schiano-Lomoriello,1 Sebastiano Serrao11Fondazione G.B. Bietti IRCCS, 2Vision Engineering Italy Srl, 3Azienda Ospedaliera San Giovanni-Addolorata, Rome, ItalyBackground: The purpose of this study was to evaluate the effect of daily administration of mannitol-enriched sodium hyaluronate ophthalmic solution on the corneal optical properties of subjects wearing low Dk hydrogel (etafilcon A) contact lenses (CLs).Methods: Forty-five subjects wearing etafilcon A CLs daily for more than 6 months were recruited into this pilot study. Fifteen of the subjects administered a 10% mannitol-enriched 0.05% sodium hyaluronate solution (study group) once daily and 30 subjects did not administer any ophthalmic solution (control group). The subjects were examined at baseline and one month after recruitment. Changes in central corneal thickness (CCT) and corneal light backscatter were evaluated by Scheimpflug imaging (Pentacam HR). Changes in corneal total high-order aberration, corneal spherical aberration, coma, and trefoil were evaluated using the OPD scan II.Results: At one month, corneal light backscatter decreased significantly in the study group (≤18.30 arbitrary units; P<0.05) and this was highly correlated with a decrease in CCT (R=0.81; P=0.04). The decrease in corneal total high-order aberration, spherical aberration, and coma was significantly higher in the study group than in the control group (P<0.05). No changes in corneal light backscatter or CCT were found in the control group during follow-up.Conclusion: Once-daily administration of a mannitol-enriched lubricant ophthalmic solution was effective for improving the corneal optical quality and reducing corneal swelling in subjects wearing low Dk hydrogel (etafilcon A) CLs during one month follow-up.Keywords: corneal optical quality, corneal high-order aberrations, Scheimpflug imaging, corneal backscattering, contact lens, hypertonic lubricant solution
format article
author Lombardo M
Rosati M
Pileri M
Schiano-Lomoriello D
Serrao S
author_facet Lombardo M
Rosati M
Pileri M
Schiano-Lomoriello D
Serrao S
author_sort Lombardo M
title Evaluation of corneal optical properties in subjects wearing hydrogel etafilcon A contact lenses and the effect of administering mannitol-enriched sodium hyaluronate ophthalmic solution
title_short Evaluation of corneal optical properties in subjects wearing hydrogel etafilcon A contact lenses and the effect of administering mannitol-enriched sodium hyaluronate ophthalmic solution
title_full Evaluation of corneal optical properties in subjects wearing hydrogel etafilcon A contact lenses and the effect of administering mannitol-enriched sodium hyaluronate ophthalmic solution
title_fullStr Evaluation of corneal optical properties in subjects wearing hydrogel etafilcon A contact lenses and the effect of administering mannitol-enriched sodium hyaluronate ophthalmic solution
title_full_unstemmed Evaluation of corneal optical properties in subjects wearing hydrogel etafilcon A contact lenses and the effect of administering mannitol-enriched sodium hyaluronate ophthalmic solution
title_sort evaluation of corneal optical properties in subjects wearing hydrogel etafilcon a contact lenses and the effect of administering mannitol-enriched sodium hyaluronate ophthalmic solution
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/e6a53ff6c851473ea7b0884e9458ba59
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