Off-label use of drugs administered by enteral feeding tubes in an Intensive Care Unit in Fortaleza, Brazil
Objective: To analyze the prescription profile of drugs administered through enteral feeding tubes in an adult intensive care unit and gather recommendations for their safe administration. Methods: This is a descriptive and retrospective study conducted with adult critical clinical patients of a un...
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Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde
2021
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oai:doaj.org-article:e6a6b94a5a63457aa4d28c075e7280632021-11-28T02:43:54ZOff-label use of drugs administered by enteral feeding tubes in an Intensive Care Unit in Fortaleza, Brazil10.30968/rbfhss.2021.121.05622179-59242316-7750https://doaj.org/article/e6a6b94a5a63457aa4d28c075e7280632021-03-01T00:00:00Zhttps://www.rbfhss.org.br/sbrafh/article/view/562https://doaj.org/toc/2179-5924https://doaj.org/toc/2316-7750 Objective: To analyze the prescription profile of drugs administered through enteral feeding tubes in an adult intensive care unit and gather recommendations for their safe administration. Methods: This is a descriptive and retrospective study conducted with adult critical clinical patients of a university hospital in Fortaleza-Ceará from March to May 2018. We performed analyses of patients’ medical records and prescriptions regarding drugs, pharmaceutical presentations and the possibility of administration through enteral tubes. Results: 489 prescriptions containing 1914 items were evaluated, from which 16.6% (n = 318) through tubes. Medicines for the cardiovascular system (34.6%), nervous system (27.4%) and digestive system and metabolism (15.1%) were the most predominant, with an average of 5.8 (DP: 4.2) different per patient. Regarding the pharmaceutical presentation, oral solids were frequently prescribed via enteral tube (67.9%), especially risperidone (8.8%), carvedilol (8.3%) and amiodarone (7.9%). There were contraindications for administration through tubes in 21.6% of solid oral formulations, while there were alternative standardized pharmaceutical forms in the hospital for 43.1%. In addition, substitution for liquid preparations from the market were possible in 43.1%. Among those to which there were no alternative formulations, drugs targeting the cardiovascular system prevailed (52.2%). A table with guidelines for the proper administration of the prescribed solid medications was elaborated then. Conclusion: Solid oral medications were frequently prescribed through enteral tubes, especially those for the cardiovascular system without alternative formulations, which shows the need for guidelines to promote the safety of this process. Gabriela A. ABREUElana F. CHAVESJosé A. NETOLívia P. MOREIRAJohann V. SILVAAndreína F. TEIXEIRAMarjorie M. GUEDESMilena P. BESERRASociedade Brasileira de Farmácia Hospitalar e Serviços de SaúdearticlePublic aspects of medicineRA1-1270Pharmacy and materia medicaRS1-441Therapeutics. PharmacologyRM1-950ENPTRevista Brasileira de Farmácia Hospitalar e Serviços de Saúde, Vol 12, Iss 1 (2021) |
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EN PT |
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Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950 |
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Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950 Gabriela A. ABREU Elana F. CHAVES José A. NETO Lívia P. MOREIRA Johann V. SILVA Andreína F. TEIXEIRA Marjorie M. GUEDES Milena P. BESERRA Off-label use of drugs administered by enteral feeding tubes in an Intensive Care Unit in Fortaleza, Brazil |
| description |
Objective: To analyze the prescription profile of drugs administered through enteral feeding tubes in an adult intensive care unit and gather recommendations for their safe administration. Methods: This is a descriptive and retrospective study conducted with adult critical clinical patients of a university hospital in Fortaleza-Ceará from March to May 2018. We performed analyses of patients’ medical records and prescriptions regarding drugs, pharmaceutical presentations and the possibility of administration through enteral tubes. Results: 489 prescriptions containing 1914 items were evaluated, from which 16.6% (n = 318) through tubes. Medicines for the cardiovascular system (34.6%), nervous system (27.4%) and digestive system and metabolism (15.1%) were the most predominant, with an average of 5.8 (DP: 4.2) different per patient. Regarding the pharmaceutical presentation, oral solids were frequently prescribed via enteral tube (67.9%), especially risperidone (8.8%), carvedilol (8.3%) and amiodarone (7.9%). There were contraindications for administration through tubes in 21.6% of solid oral formulations, while there were alternative standardized pharmaceutical forms in the hospital for 43.1%. In addition, substitution for liquid preparations from the market were possible in 43.1%. Among those to which there were no alternative formulations, drugs targeting the cardiovascular system prevailed (52.2%). A table with guidelines for the proper administration of the prescribed solid medications was elaborated then. Conclusion: Solid oral medications were frequently prescribed through enteral tubes, especially those for the cardiovascular system without alternative formulations, which shows the need for guidelines to promote the safety of this process.
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| format |
article |
| author |
Gabriela A. ABREU Elana F. CHAVES José A. NETO Lívia P. MOREIRA Johann V. SILVA Andreína F. TEIXEIRA Marjorie M. GUEDES Milena P. BESERRA |
| author_facet |
Gabriela A. ABREU Elana F. CHAVES José A. NETO Lívia P. MOREIRA Johann V. SILVA Andreína F. TEIXEIRA Marjorie M. GUEDES Milena P. BESERRA |
| author_sort |
Gabriela A. ABREU |
| title |
Off-label use of drugs administered by enteral feeding tubes in an Intensive Care Unit in Fortaleza, Brazil |
| title_short |
Off-label use of drugs administered by enteral feeding tubes in an Intensive Care Unit in Fortaleza, Brazil |
| title_full |
Off-label use of drugs administered by enteral feeding tubes in an Intensive Care Unit in Fortaleza, Brazil |
| title_fullStr |
Off-label use of drugs administered by enteral feeding tubes in an Intensive Care Unit in Fortaleza, Brazil |
| title_full_unstemmed |
Off-label use of drugs administered by enteral feeding tubes in an Intensive Care Unit in Fortaleza, Brazil |
| title_sort |
off-label use of drugs administered by enteral feeding tubes in an intensive care unit in fortaleza, brazil |
| publisher |
Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde |
| publishDate |
2021 |
| url |
https://doaj.org/article/e6a6b94a5a63457aa4d28c075e728063 |
| work_keys_str_mv |
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