Comparison of Argentinean microbiota with other geographical populations reveals different taxonomic and functional signatures associated with obesity

Abstract Accumulating evidence suggests that various genetic and environmental factors contribute to the development of obesity. Among the latter, the gut microbiota has emerged as a critical player in the regulation of human metabolism and health and the development of non-communicable chronic dise...

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Autores principales:	Susana A. Pesoa, Nestor Portela, Eduardo Fernández, Osvaldo Elbarcha, Martin Gotteland, Fabien Magne
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e6a889af69584affabc716b5fdf45c8a
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spelling	oai:doaj.org-article:e6a889af69584affabc716b5fdf45c8a2021-12-02T14:17:19ZComparison of Argentinean microbiota with other geographical populations reveals different taxonomic and functional signatures associated with obesity10.1038/s41598-021-87365-x2045-2322https://doaj.org/article/e6a889af69584affabc716b5fdf45c8a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87365-xhttps://doaj.org/toc/2045-2322Abstract Accumulating evidence suggests that various genetic and environmental factors contribute to the development of obesity. Among the latter, the gut microbiota has emerged as a critical player in the regulation of human metabolism and health and the development of non-communicable chronic diseases. Considering that no information on this matter is available in Argentina, our aim was to identify the microorganisms associated with obesity as well as their potential functionality. Using high throughput sequencing of 16SrRNA bacterial gene and diverse bioinformatics tools, we observed that the gut microbiota of obese and overweight individuals differs qualitatively and quantitatively from that from their lean counterparts. The comparison of the gut microbiota composition in obese subjects from Argentina, US and UK showed that the beta diversity significantly differs among the three countries, indicating that obesity-associated microbiota composition changes according to the geographical origin of the individuals. Moreover, four distinct microbiotypes were identified in obese individuals, whose prevalence and metabolic pathway signature differed according to the country, indicating that obesity associated dysbiosis would comprise several structures. In summary, identification of distinct taxonomic signatures associated with obesity might be a novel promising tool to stratify patients based on their microbiome configuration to design strategies for managing obesity.Susana A. PesoaNestor PortelaEduardo FernándezOsvaldo ElbarchaMartin GottelandFabien MagneNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Susana A. Pesoa Nestor Portela Eduardo Fernández Osvaldo Elbarcha Martin Gotteland Fabien Magne Comparison of Argentinean microbiota with other geographical populations reveals different taxonomic and functional signatures associated with obesity
description	Abstract Accumulating evidence suggests that various genetic and environmental factors contribute to the development of obesity. Among the latter, the gut microbiota has emerged as a critical player in the regulation of human metabolism and health and the development of non-communicable chronic diseases. Considering that no information on this matter is available in Argentina, our aim was to identify the microorganisms associated with obesity as well as their potential functionality. Using high throughput sequencing of 16SrRNA bacterial gene and diverse bioinformatics tools, we observed that the gut microbiota of obese and overweight individuals differs qualitatively and quantitatively from that from their lean counterparts. The comparison of the gut microbiota composition in obese subjects from Argentina, US and UK showed that the beta diversity significantly differs among the three countries, indicating that obesity-associated microbiota composition changes according to the geographical origin of the individuals. Moreover, four distinct microbiotypes were identified in obese individuals, whose prevalence and metabolic pathway signature differed according to the country, indicating that obesity associated dysbiosis would comprise several structures. In summary, identification of distinct taxonomic signatures associated with obesity might be a novel promising tool to stratify patients based on their microbiome configuration to design strategies for managing obesity.
format	article
author	Susana A. Pesoa Nestor Portela Eduardo Fernández Osvaldo Elbarcha Martin Gotteland Fabien Magne
author_facet	Susana A. Pesoa Nestor Portela Eduardo Fernández Osvaldo Elbarcha Martin Gotteland Fabien Magne
author_sort	Susana A. Pesoa
title	Comparison of Argentinean microbiota with other geographical populations reveals different taxonomic and functional signatures associated with obesity
title_short	Comparison of Argentinean microbiota with other geographical populations reveals different taxonomic and functional signatures associated with obesity
title_full	Comparison of Argentinean microbiota with other geographical populations reveals different taxonomic and functional signatures associated with obesity
title_fullStr	Comparison of Argentinean microbiota with other geographical populations reveals different taxonomic and functional signatures associated with obesity
title_full_unstemmed	Comparison of Argentinean microbiota with other geographical populations reveals different taxonomic and functional signatures associated with obesity
title_sort	comparison of argentinean microbiota with other geographical populations reveals different taxonomic and functional signatures associated with obesity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e6a889af69584affabc716b5fdf45c8a
work_keys_str_mv	AT susanaapesoa comparisonofargentineanmicrobiotawithothergeographicalpopulationsrevealsdifferenttaxonomicandfunctionalsignaturesassociatedwithobesity AT nestorportela comparisonofargentineanmicrobiotawithothergeographicalpopulationsrevealsdifferenttaxonomicandfunctionalsignaturesassociatedwithobesity AT eduardofernandez comparisonofargentineanmicrobiotawithothergeographicalpopulationsrevealsdifferenttaxonomicandfunctionalsignaturesassociatedwithobesity AT osvaldoelbarcha comparisonofargentineanmicrobiotawithothergeographicalpopulationsrevealsdifferenttaxonomicandfunctionalsignaturesassociatedwithobesity AT martingotteland comparisonofargentineanmicrobiotawithothergeographicalpopulationsrevealsdifferenttaxonomicandfunctionalsignaturesassociatedwithobesity AT fabienmagne comparisonofargentineanmicrobiotawithothergeographicalpopulationsrevealsdifferenttaxonomicandfunctionalsignaturesassociatedwithobesity
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Comparison of Argentinean microbiota with other geographical populations reveals different taxonomic and functional signatures associated with obesity

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