Rho GTPases in Skeletal Muscle Development and Homeostasis

Rho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle between an inactive guanosine diphosphate (GDP)-bound and an active guanosine triphosphate (GTP)-bound state during signal transduction. As such, they regulate a wide range of both cellular and physiological processes....

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Autores principales:	Sonia Rodríguez-Fdez, Xosé R. Bustelo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	small G protein RhoA Rac1 Cdc42 guanosine nucleotide exchange factors GTPase activating proteins Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e6a95c5e87654111b521eec414bf7d9e
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spelling	oai:doaj.org-article:e6a95c5e87654111b521eec414bf7d9e2021-11-25T17:10:00ZRho GTPases in Skeletal Muscle Development and Homeostasis10.3390/cells101129842073-4409https://doaj.org/article/e6a95c5e87654111b521eec414bf7d9e2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2984https://doaj.org/toc/2073-4409Rho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle between an inactive guanosine diphosphate (GDP)-bound and an active guanosine triphosphate (GTP)-bound state during signal transduction. As such, they regulate a wide range of both cellular and physiological processes. In this review, we will summarize recent work on the role of Rho GTPase-regulated pathways in skeletal muscle development, regeneration, tissue mass homeostatic balance, and metabolism. In addition, we will present current evidence that links the dysregulation of these GTPases with diseases caused by skeletal muscle dysfunction. Overall, this information underscores the critical role of a number of members of the Rho GTPase subfamily in muscle development and the overall metabolic balance of mammalian species.Sonia Rodríguez-FdezXosé R. BusteloMDPI AGarticlesmall G proteinRhoARac1Cdc42guanosine nucleotide exchange factorsGTPase activating proteinsBiology (General)QH301-705.5ENCells, Vol 10, Iss 2984, p 2984 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	small G protein RhoA Rac1 Cdc42 guanosine nucleotide exchange factors GTPase activating proteins Biology (General) QH301-705.5
spellingShingle	small G protein RhoA Rac1 Cdc42 guanosine nucleotide exchange factors GTPase activating proteins Biology (General) QH301-705.5 Sonia Rodríguez-Fdez Xosé R. Bustelo Rho GTPases in Skeletal Muscle Development and Homeostasis
description	Rho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle between an inactive guanosine diphosphate (GDP)-bound and an active guanosine triphosphate (GTP)-bound state during signal transduction. As such, they regulate a wide range of both cellular and physiological processes. In this review, we will summarize recent work on the role of Rho GTPase-regulated pathways in skeletal muscle development, regeneration, tissue mass homeostatic balance, and metabolism. In addition, we will present current evidence that links the dysregulation of these GTPases with diseases caused by skeletal muscle dysfunction. Overall, this information underscores the critical role of a number of members of the Rho GTPase subfamily in muscle development and the overall metabolic balance of mammalian species.
format	article
author	Sonia Rodríguez-Fdez Xosé R. Bustelo
author_facet	Sonia Rodríguez-Fdez Xosé R. Bustelo
author_sort	Sonia Rodríguez-Fdez
title	Rho GTPases in Skeletal Muscle Development and Homeostasis
title_short	Rho GTPases in Skeletal Muscle Development and Homeostasis
title_full	Rho GTPases in Skeletal Muscle Development and Homeostasis
title_fullStr	Rho GTPases in Skeletal Muscle Development and Homeostasis
title_full_unstemmed	Rho GTPases in Skeletal Muscle Development and Homeostasis
title_sort	rho gtpases in skeletal muscle development and homeostasis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e6a95c5e87654111b521eec414bf7d9e
work_keys_str_mv	AT soniarodriguezfdez rhogtpasesinskeletalmuscledevelopmentandhomeostasis AT xoserbustelo rhogtpasesinskeletalmuscledevelopmentandhomeostasis
_version_	1718412685993836544

Rho GTPases in Skeletal Muscle Development and Homeostasis

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