Influence of immunodeficiency and systemic use of antiretroviral drugs on the structure of skin and mucosa diseases in patients with HIV infection

The aim of the research was to explore range of skin and mucous membrane pathology in patients with HIV infection in Sverdlovsk region, assess the impact on it the severity of immunodeficiency, systemic receiving antiretroviral drugs. The study included 459 patients with HIV infection. The patients...

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Autores principales:	A. S. Podymova, S. V. Prozherin, E. P. Ryamova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	cd4+ т-лимфоциты hiv infection cd4+ t-lymphocytes antiretroviral therapy skin diseases Science Q
Acceso en línea:	https://doaj.org/article/e6ae376f81044efda131ddc4c8241766
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spelling	oai:doaj.org-article:e6ae376f81044efda131ddc4c82417662021-11-23T06:14:35ZInfluence of immunodeficiency and systemic use of antiretroviral drugs on the structure of skin and mucosa diseases in patients with HIV infection2541-94202587-959610.12737/23348https://doaj.org/article/e6ae376f81044efda131ddc4c82417662016-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/275https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The aim of the research was to explore range of skin and mucous membrane pathology in patients with HIV infection in Sverdlovsk region, assess the impact on it the severity of immunodeficiency, systemic receiving antiretroviral drugs. The study included 459 patients with HIV infection. The patients were divided into two groups: Group 1 (core) - patients on antiretroviral therapy (ART), 133 people, group 2 (control group) - 326 HIV-persons who are not receiving ART. The control group is represented by two subgroups: 2A - patients with a level of CD4+ T-lymphocyte cells > 350/ßl (153 patients) and 2B -173 HIV-positive with the amount of CD4+ cells less than 350/ßl. Among HIV-infected patients not receiving ART, with the level of CD4+ T-cells below 350 cells/ßl were significantly more lesions detected candida, hairy leukoplakia tongue (p < 0,01), seborrheic dermatitis, psoriasis (p < 0.05), when CD4+ > 350 cells/ßl - skin xerosis (p < 0,05). On the background of the systematic intake of antiretroviral drugs we detected reduced frequency of candidiasis (from 21.5 % to 6.8 %), of herpes zoster (from 6.1 % to 0.8 %), and of hairy leukoplakia (absent on the background of ART), on the other hand we revealed increase occurrence of impairments caused by human papilloma virus.A. S. PodymovaS. V. ProzherinE. P. RyamovaScientific Сentre for Family Health and Human Reproduction Problemsarticlecd4+ т-лимфоцитыhiv infectioncd4+ t-lymphocytesantiretroviral therapyskin diseasesScienceQRUActa Biomedica Scientifica, Vol 1, Iss 5, Pp 40-45 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	cd4+ т-лимфоциты hiv infection cd4+ t-lymphocytes antiretroviral therapy skin diseases Science Q
spellingShingle	cd4+ т-лимфоциты hiv infection cd4+ t-lymphocytes antiretroviral therapy skin diseases Science Q A. S. Podymova S. V. Prozherin E. P. Ryamova Influence of immunodeficiency and systemic use of antiretroviral drugs on the structure of skin and mucosa diseases in patients with HIV infection
description	The aim of the research was to explore range of skin and mucous membrane pathology in patients with HIV infection in Sverdlovsk region, assess the impact on it the severity of immunodeficiency, systemic receiving antiretroviral drugs. The study included 459 patients with HIV infection. The patients were divided into two groups: Group 1 (core) - patients on antiretroviral therapy (ART), 133 people, group 2 (control group) - 326 HIV-persons who are not receiving ART. The control group is represented by two subgroups: 2A - patients with a level of CD4+ T-lymphocyte cells > 350/ßl (153 patients) and 2B -173 HIV-positive with the amount of CD4+ cells less than 350/ßl. Among HIV-infected patients not receiving ART, with the level of CD4+ T-cells below 350 cells/ßl were significantly more lesions detected candida, hairy leukoplakia tongue (p < 0,01), seborrheic dermatitis, psoriasis (p < 0.05), when CD4+ > 350 cells/ßl - skin xerosis (p < 0,05). On the background of the systematic intake of antiretroviral drugs we detected reduced frequency of candidiasis (from 21.5 % to 6.8 %), of herpes zoster (from 6.1 % to 0.8 %), and of hairy leukoplakia (absent on the background of ART), on the other hand we revealed increase occurrence of impairments caused by human papilloma virus.
format	article
author	A. S. Podymova S. V. Prozherin E. P. Ryamova
author_facet	A. S. Podymova S. V. Prozherin E. P. Ryamova
author_sort	A. S. Podymova
title	Influence of immunodeficiency and systemic use of antiretroviral drugs on the structure of skin and mucosa diseases in patients with HIV infection
title_short	Influence of immunodeficiency and systemic use of antiretroviral drugs on the structure of skin and mucosa diseases in patients with HIV infection
title_full	Influence of immunodeficiency and systemic use of antiretroviral drugs on the structure of skin and mucosa diseases in patients with HIV infection
title_fullStr	Influence of immunodeficiency and systemic use of antiretroviral drugs on the structure of skin and mucosa diseases in patients with HIV infection
title_full_unstemmed	Influence of immunodeficiency and systemic use of antiretroviral drugs on the structure of skin and mucosa diseases in patients with HIV infection
title_sort	influence of immunodeficiency and systemic use of antiretroviral drugs on the structure of skin and mucosa diseases in patients with hiv infection
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/e6ae376f81044efda131ddc4c8241766
work_keys_str_mv	AT aspodymova influenceofimmunodeficiencyandsystemicuseofantiretroviraldrugsonthestructureofskinandmucosadiseasesinpatientswithhivinfection AT svprozherin influenceofimmunodeficiencyandsystemicuseofantiretroviraldrugsonthestructureofskinandmucosadiseasesinpatientswithhivinfection AT epryamova influenceofimmunodeficiencyandsystemicuseofantiretroviraldrugsonthestructureofskinandmucosadiseasesinpatientswithhivinfection
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Influence of immunodeficiency and systemic use of antiretroviral drugs on the structure of skin and mucosa diseases in patients with HIV infection

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