Decomposition and oxidation of methionine and tryptophan following irradiation with a nonequilibrium plasma jet and applications for killing cancer cells
Abstract We present evidence for the decomposition and oxidation of amino acids in aqueous solution following irradiation with a nonequilibrium plasma jet. Of 15 amino acids tested in cell culture medium, plasma irradiation induced a marked chemical change in methionine and tryptophan due to the eff...
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Nature Portfolio
2019
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oai:doaj.org-article:e6b0451c744c4c50885728221b69c74a2021-12-02T15:09:54ZDecomposition and oxidation of methionine and tryptophan following irradiation with a nonequilibrium plasma jet and applications for killing cancer cells10.1038/s41598-019-42959-42045-2322https://doaj.org/article/e6b0451c744c4c50885728221b69c74a2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-42959-4https://doaj.org/toc/2045-2322Abstract We present evidence for the decomposition and oxidation of amino acids in aqueous solution following irradiation with a nonequilibrium plasma jet. Of 15 amino acids tested in cell culture medium, plasma irradiation induced a marked chemical change in methionine and tryptophan due to the effective production of reactive oxygen species by plasma-water interaction. We also report that plasma-treated methionine and tryptophan aqueous solutions can kill cancer cells, greatly decreasing the viability of human endometrial carcinoma (HEC-1) cancer cells due to the presence of decomposition or oxidation products generated from the amino acid. Plasma-treated methionine and tryptophan aqueous solutions also induced an anti-cancer effect on cancer-initiating cells.Giichiro UchidaYusuke MinoTensho SuzukiJun-ichiro IkedaTakashi SuzukiKosuke TakenakaYuichi SetsuharaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-17 (2019) |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Giichiro Uchida Yusuke Mino Tensho Suzuki Jun-ichiro Ikeda Takashi Suzuki Kosuke Takenaka Yuichi Setsuhara Decomposition and oxidation of methionine and tryptophan following irradiation with a nonequilibrium plasma jet and applications for killing cancer cells |
| description |
Abstract We present evidence for the decomposition and oxidation of amino acids in aqueous solution following irradiation with a nonequilibrium plasma jet. Of 15 amino acids tested in cell culture medium, plasma irradiation induced a marked chemical change in methionine and tryptophan due to the effective production of reactive oxygen species by plasma-water interaction. We also report that plasma-treated methionine and tryptophan aqueous solutions can kill cancer cells, greatly decreasing the viability of human endometrial carcinoma (HEC-1) cancer cells due to the presence of decomposition or oxidation products generated from the amino acid. Plasma-treated methionine and tryptophan aqueous solutions also induced an anti-cancer effect on cancer-initiating cells. |
| format |
article |
| author |
Giichiro Uchida Yusuke Mino Tensho Suzuki Jun-ichiro Ikeda Takashi Suzuki Kosuke Takenaka Yuichi Setsuhara |
| author_facet |
Giichiro Uchida Yusuke Mino Tensho Suzuki Jun-ichiro Ikeda Takashi Suzuki Kosuke Takenaka Yuichi Setsuhara |
| author_sort |
Giichiro Uchida |
| title |
Decomposition and oxidation of methionine and tryptophan following irradiation with a nonequilibrium plasma jet and applications for killing cancer cells |
| title_short |
Decomposition and oxidation of methionine and tryptophan following irradiation with a nonequilibrium plasma jet and applications for killing cancer cells |
| title_full |
Decomposition and oxidation of methionine and tryptophan following irradiation with a nonequilibrium plasma jet and applications for killing cancer cells |
| title_fullStr |
Decomposition and oxidation of methionine and tryptophan following irradiation with a nonequilibrium plasma jet and applications for killing cancer cells |
| title_full_unstemmed |
Decomposition and oxidation of methionine and tryptophan following irradiation with a nonequilibrium plasma jet and applications for killing cancer cells |
| title_sort |
decomposition and oxidation of methionine and tryptophan following irradiation with a nonequilibrium plasma jet and applications for killing cancer cells |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/e6b0451c744c4c50885728221b69c74a |
| work_keys_str_mv |
AT giichirouchida decompositionandoxidationofmethionineandtryptophanfollowingirradiationwithanonequilibriumplasmajetandapplicationsforkillingcancercells AT yusukemino decompositionandoxidationofmethionineandtryptophanfollowingirradiationwithanonequilibriumplasmajetandapplicationsforkillingcancercells AT tenshosuzuki decompositionandoxidationofmethionineandtryptophanfollowingirradiationwithanonequilibriumplasmajetandapplicationsforkillingcancercells AT junichiroikeda decompositionandoxidationofmethionineandtryptophanfollowingirradiationwithanonequilibriumplasmajetandapplicationsforkillingcancercells AT takashisuzuki decompositionandoxidationofmethionineandtryptophanfollowingirradiationwithanonequilibriumplasmajetandapplicationsforkillingcancercells AT kosuketakenaka decompositionandoxidationofmethionineandtryptophanfollowingirradiationwithanonequilibriumplasmajetandapplicationsforkillingcancercells AT yuichisetsuhara decompositionandoxidationofmethionineandtryptophanfollowingirradiationwithanonequilibriumplasmajetandapplicationsforkillingcancercells |
| _version_ |
1718387787058642944 |