Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells

The outer lining or cortex of the human ovary determines fertility and has been postulated to contain oogonial stem cells. Here, the authors generate a single-cell map of the adult human ovarian cortex and show that DDX4 labels perivascular cells but no oogonial stem cells.

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Autores principales:	Magdalena Wagner, Masahito Yoshihara, Iyadh Douagi, Anastasios Damdimopoulos, Sarita Panula, Sophie Petropoulos, Haojiang Lu, Karin Pettersson, Kerstin Palm, Shintaro Katayama, Outi Hovatta, Juha Kere, Fredrik Lanner, Pauliina Damdimopoulou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6b0eb324cf54b6ca3c0777743fe76df
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spelling	oai:doaj.org-article:e6b0eb324cf54b6ca3c0777743fe76df2021-12-02T17:31:25ZSingle-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells10.1038/s41467-020-14936-32041-1723https://doaj.org/article/e6b0eb324cf54b6ca3c0777743fe76df2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14936-3https://doaj.org/toc/2041-1723The outer lining or cortex of the human ovary determines fertility and has been postulated to contain oogonial stem cells. Here, the authors generate a single-cell map of the adult human ovarian cortex and show that DDX4 labels perivascular cells but no oogonial stem cells.Magdalena WagnerMasahito YoshiharaIyadh DouagiAnastasios DamdimopoulosSarita PanulaSophie PetropoulosHaojiang LuKarin PetterssonKerstin PalmShintaro KatayamaOuti HovattaJuha KereFredrik LannerPauliina DamdimopoulouNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Magdalena Wagner Masahito Yoshihara Iyadh Douagi Anastasios Damdimopoulos Sarita Panula Sophie Petropoulos Haojiang Lu Karin Pettersson Kerstin Palm Shintaro Katayama Outi Hovatta Juha Kere Fredrik Lanner Pauliina Damdimopoulou Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells
description	The outer lining or cortex of the human ovary determines fertility and has been postulated to contain oogonial stem cells. Here, the authors generate a single-cell map of the adult human ovarian cortex and show that DDX4 labels perivascular cells but no oogonial stem cells.
format	article
author	Magdalena Wagner Masahito Yoshihara Iyadh Douagi Anastasios Damdimopoulos Sarita Panula Sophie Petropoulos Haojiang Lu Karin Pettersson Kerstin Palm Shintaro Katayama Outi Hovatta Juha Kere Fredrik Lanner Pauliina Damdimopoulou
author_facet	Magdalena Wagner Masahito Yoshihara Iyadh Douagi Anastasios Damdimopoulos Sarita Panula Sophie Petropoulos Haojiang Lu Karin Pettersson Kerstin Palm Shintaro Katayama Outi Hovatta Juha Kere Fredrik Lanner Pauliina Damdimopoulou
author_sort	Magdalena Wagner
title	Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells
title_short	Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells
title_full	Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells
title_fullStr	Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells
title_full_unstemmed	Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells
title_sort	single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e6b0eb324cf54b6ca3c0777743fe76df
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Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells

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