AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma

Basal cell carcinoma (BCC) cells with increased nuclear myocardin-related transcription factor (nMRTF) levels are resistant to Smoothened inhibitors, however how MRTF activity is regulated is still elusive. Here, the authors identify a LYPD3+/TACSTD2+/LY6D+ BCC subpopulation of resistant BCC cells w...

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Autores principales:	Catherine D. Yao, Daniel Haensel, Sadhana Gaddam, Tiffany Patel, Scott X. Atwood, Kavita Y. Sarin, Ramon J. Whitson, Siegen McKellar, Gautam Shankar, Sumaira Aasi, Kerri Rieger, Anthony E. Oro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6b18a583afe4ea5bde3d4d2f73b777e
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spelling	oai:doaj.org-article:e6b18a583afe4ea5bde3d4d2f73b777e2021-12-02T19:16:29ZAP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma10.1038/s41467-020-18762-52041-1723https://doaj.org/article/e6b18a583afe4ea5bde3d4d2f73b777e2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18762-5https://doaj.org/toc/2041-1723Basal cell carcinoma (BCC) cells with increased nuclear myocardin-related transcription factor (nMRTF) levels are resistant to Smoothened inhibitors, however how MRTF activity is regulated is still elusive. Here, the authors identify a LYPD3+/TACSTD2+/LY6D+ BCC subpopulation of resistant BCC cells where AP-1 and TGFß drive nMRTF activation and amplify noncanonical Gli1 activityCatherine D. YaoDaniel HaenselSadhana GaddamTiffany PatelScott X. AtwoodKavita Y. SarinRamon J. WhitsonSiegen McKellarGautam ShankarSumaira AasiKerri RiegerAnthony E. OroNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Catherine D. Yao Daniel Haensel Sadhana Gaddam Tiffany Patel Scott X. Atwood Kavita Y. Sarin Ramon J. Whitson Siegen McKellar Gautam Shankar Sumaira Aasi Kerri Rieger Anthony E. Oro AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma
description	Basal cell carcinoma (BCC) cells with increased nuclear myocardin-related transcription factor (nMRTF) levels are resistant to Smoothened inhibitors, however how MRTF activity is regulated is still elusive. Here, the authors identify a LYPD3+/TACSTD2+/LY6D+ BCC subpopulation of resistant BCC cells where AP-1 and TGFß drive nMRTF activation and amplify noncanonical Gli1 activity
format	article
author	Catherine D. Yao Daniel Haensel Sadhana Gaddam Tiffany Patel Scott X. Atwood Kavita Y. Sarin Ramon J. Whitson Siegen McKellar Gautam Shankar Sumaira Aasi Kerri Rieger Anthony E. Oro
author_facet	Catherine D. Yao Daniel Haensel Sadhana Gaddam Tiffany Patel Scott X. Atwood Kavita Y. Sarin Ramon J. Whitson Siegen McKellar Gautam Shankar Sumaira Aasi Kerri Rieger Anthony E. Oro
author_sort	Catherine D. Yao
title	AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma
title_short	AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma
title_full	AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma
title_fullStr	AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma
title_full_unstemmed	AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma
title_sort	ap-1 and tgfß cooperativity drives non-canonical hedgehog signaling in resistant basal cell carcinoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e6b18a583afe4ea5bde3d4d2f73b777e
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AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma

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