Cryotherapy for Prevention of Taxane-Induced Peripheral Neuropathy: A Meta-Analysis

PurposeTaxanes are widely used in gynecological cancer therapy, however, taxane-induced peripheral neuropathy (TIPN) limits chemotherapy dose and reduces patients’ quality of life. As a safe and convenient intervention, cryotherapy has been recommended as a promising intervention in the recent clini...

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Autores principales:	Junting Jia, Yimeng Guo, Raghav Sundar, Aishwarya Bandla, Zhiying Hao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cryotherapy prevention taxane peripheral neuropathy meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e6b3033b72f9472d89be439157e9c8d1
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spelling	oai:doaj.org-article:e6b3033b72f9472d89be439157e9c8d12021-12-01T13:40:24ZCryotherapy for Prevention of Taxane-Induced Peripheral Neuropathy: A Meta-Analysis2234-943X10.3389/fonc.2021.781812https://doaj.org/article/e6b3033b72f9472d89be439157e9c8d12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.781812/fullhttps://doaj.org/toc/2234-943XPurposeTaxanes are widely used in gynecological cancer therapy, however, taxane-induced peripheral neuropathy (TIPN) limits chemotherapy dose and reduces patients’ quality of life. As a safe and convenient intervention, cryotherapy has been recommended as a promising intervention in the recent clinical guidelines for the prevention of TIPN. Although there are a considerable number of studies which explored the use of cryotherapy in preventing chemotherapy-induced peripheral neuropathy (CIPN), there is insufficient large-scale clinical evidence. We performed a meta-analysis on the current available evidence to examine whether cryotherapy can prevent TIPN in cancer patients receiving taxanes.MethodsWe searched databases including PubMed, Embase, and Cochrane from inception to August 3, 2021 for eligible trials. Clinical trials that examined the efficacy of cryotherapy for prevention of TIPN were included. The primary outcome was the incidence of TIPN, and secondary outcomes were incidence of taxane dose reduction and changes in nerve conduction studies. The meta-analysis software (RevMan 5.3) was used to analyze the data.ResultsWe analyzed 2250 patients from 9 trials. Assessments using the Common Terminology Criteria for Adverse Events (CTCAE) score showed that cryotherapy could significantly reduce the incidence of motor and sensory neuropathy of grade≥2 (sensory: RR 0.65, 95%CI 0.56 to 0.75, p<0.00001; motor: RR 0.18, 95% CI [0.03, 0.94], p=0.04). When evaluated using the Patient Neuropathy Questionnaire (PNQ), cryotherapy demonstrated significant reduction in the incidence of sensory neuropathy (RR 0.11, 95% CI 0.04 to 0.31], p<0.0001), but did not show significant reduction in the incidence of motor neuropathy (RR 0.46, 95% CI 0.11 to 1.88, p=0.28). Cryotherapy was associated with reduced incidences of taxane dose reduction due to TIPN (RR 0.48, 95% CI [0.24, 0.95], p=0.04) and had potential to preserve motor nerves.ConclusionsCryotherapy is likely to prevent TIPN in patients receiving taxanes. High quality and sufficient amount of evidence is warranted.Junting JiaYimeng GuoRaghav SundarRaghav SundarRaghav SundarRaghav SundarAishwarya BandlaAishwarya BandlaZhiying HaoFrontiers Media S.A.articlecryotherapypreventiontaxaneperipheral neuropathymeta-analysisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cryotherapy prevention taxane peripheral neuropathy meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cryotherapy prevention taxane peripheral neuropathy meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Junting Jia Yimeng Guo Raghav Sundar Raghav Sundar Raghav Sundar Raghav Sundar Aishwarya Bandla Aishwarya Bandla Zhiying Hao Cryotherapy for Prevention of Taxane-Induced Peripheral Neuropathy: A Meta-Analysis
description	PurposeTaxanes are widely used in gynecological cancer therapy, however, taxane-induced peripheral neuropathy (TIPN) limits chemotherapy dose and reduces patients’ quality of life. As a safe and convenient intervention, cryotherapy has been recommended as a promising intervention in the recent clinical guidelines for the prevention of TIPN. Although there are a considerable number of studies which explored the use of cryotherapy in preventing chemotherapy-induced peripheral neuropathy (CIPN), there is insufficient large-scale clinical evidence. We performed a meta-analysis on the current available evidence to examine whether cryotherapy can prevent TIPN in cancer patients receiving taxanes.MethodsWe searched databases including PubMed, Embase, and Cochrane from inception to August 3, 2021 for eligible trials. Clinical trials that examined the efficacy of cryotherapy for prevention of TIPN were included. The primary outcome was the incidence of TIPN, and secondary outcomes were incidence of taxane dose reduction and changes in nerve conduction studies. The meta-analysis software (RevMan 5.3) was used to analyze the data.ResultsWe analyzed 2250 patients from 9 trials. Assessments using the Common Terminology Criteria for Adverse Events (CTCAE) score showed that cryotherapy could significantly reduce the incidence of motor and sensory neuropathy of grade≥2 (sensory: RR 0.65, 95%CI 0.56 to 0.75, p<0.00001; motor: RR 0.18, 95% CI [0.03, 0.94], p=0.04). When evaluated using the Patient Neuropathy Questionnaire (PNQ), cryotherapy demonstrated significant reduction in the incidence of sensory neuropathy (RR 0.11, 95% CI 0.04 to 0.31], p<0.0001), but did not show significant reduction in the incidence of motor neuropathy (RR 0.46, 95% CI 0.11 to 1.88, p=0.28). Cryotherapy was associated with reduced incidences of taxane dose reduction due to TIPN (RR 0.48, 95% CI [0.24, 0.95], p=0.04) and had potential to preserve motor nerves.ConclusionsCryotherapy is likely to prevent TIPN in patients receiving taxanes. High quality and sufficient amount of evidence is warranted.
format	article
author	Junting Jia Yimeng Guo Raghav Sundar Raghav Sundar Raghav Sundar Raghav Sundar Aishwarya Bandla Aishwarya Bandla Zhiying Hao
author_facet	Junting Jia Yimeng Guo Raghav Sundar Raghav Sundar Raghav Sundar Raghav Sundar Aishwarya Bandla Aishwarya Bandla Zhiying Hao
author_sort	Junting Jia
title	Cryotherapy for Prevention of Taxane-Induced Peripheral Neuropathy: A Meta-Analysis
title_short	Cryotherapy for Prevention of Taxane-Induced Peripheral Neuropathy: A Meta-Analysis
title_full	Cryotherapy for Prevention of Taxane-Induced Peripheral Neuropathy: A Meta-Analysis
title_fullStr	Cryotherapy for Prevention of Taxane-Induced Peripheral Neuropathy: A Meta-Analysis
title_full_unstemmed	Cryotherapy for Prevention of Taxane-Induced Peripheral Neuropathy: A Meta-Analysis
title_sort	cryotherapy for prevention of taxane-induced peripheral neuropathy: a meta-analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e6b3033b72f9472d89be439157e9c8d1
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Cryotherapy for Prevention of Taxane-Induced Peripheral Neuropathy: A Meta-Analysis

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