Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells

Splenic marginal zone macrophages can establish immune tolerance and limit the development of systemic lupus erythematosus (SLE). Here the authors show that these cells do this by clearing apoptotic cells, and defects in these cells result in the generation of self-reactive double negative T cells t...

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Autores principales:	Hao Li, Iannis E. Adamopoulos, Vaishali R. Moulton, Isaac E. Stillman, Zach Herbert, James J. Moon, Amir Sharabi, Suzanne Krishfield, Maria G. Tsokos, George C. Tsokos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6b55468c2854d60ac861be67cb25f57
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spelling	oai:doaj.org-article:e6b55468c2854d60ac861be67cb25f572021-12-02T15:56:39ZSystemic lupus erythematosus favors the generation of IL-17 producing double negative T cells10.1038/s41467-020-16636-42041-1723https://doaj.org/article/e6b55468c2854d60ac861be67cb25f572020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16636-4https://doaj.org/toc/2041-1723Splenic marginal zone macrophages can establish immune tolerance and limit the development of systemic lupus erythematosus (SLE). Here the authors show that these cells do this by clearing apoptotic cells, and defects in these cells result in the generation of self-reactive double negative T cells that are known to contribute to SLE pathogenesis.Hao LiIannis E. AdamopoulosVaishali R. MoultonIsaac E. StillmanZach HerbertJames J. MoonAmir SharabiSuzanne KrishfieldMaria G. TsokosGeorge C. TsokosNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hao Li Iannis E. Adamopoulos Vaishali R. Moulton Isaac E. Stillman Zach Herbert James J. Moon Amir Sharabi Suzanne Krishfield Maria G. Tsokos George C. Tsokos Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells
description	Splenic marginal zone macrophages can establish immune tolerance and limit the development of systemic lupus erythematosus (SLE). Here the authors show that these cells do this by clearing apoptotic cells, and defects in these cells result in the generation of self-reactive double negative T cells that are known to contribute to SLE pathogenesis.
format	article
author	Hao Li Iannis E. Adamopoulos Vaishali R. Moulton Isaac E. Stillman Zach Herbert James J. Moon Amir Sharabi Suzanne Krishfield Maria G. Tsokos George C. Tsokos
author_facet	Hao Li Iannis E. Adamopoulos Vaishali R. Moulton Isaac E. Stillman Zach Herbert James J. Moon Amir Sharabi Suzanne Krishfield Maria G. Tsokos George C. Tsokos
author_sort	Hao Li
title	Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells
title_short	Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells
title_full	Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells
title_fullStr	Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells
title_full_unstemmed	Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells
title_sort	systemic lupus erythematosus favors the generation of il-17 producing double negative t cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e6b55468c2854d60ac861be67cb25f57
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Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells

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