Cone dysfunctions in retinitis pigmentosa with retinal nerve fiber layer thickening

Cone dysfunctions in retinitis pigmentosa with retinal nerve fiber layer thickening

Güngör Sobaci, Gökhan Özge, Fatih Ç GündoğanDepartment of Ophthalmology, Gülhane Military Medical Academy and Medical School, Etlik, Ankara, TurkeyPurpose: To investigate whether or not thicker retinal nerve...

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Autores principales: Sobaci G, Özge G, Gündoğan FÇ
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2012
Materias:
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/e6b9e8da4bbe4ad6b8a6eed1fe96bc4f
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spelling oai:doaj.org-article:e6b9e8da4bbe4ad6b8a6eed1fe96bc4f2021-12-02T03:16:25ZCone dysfunctions in retinitis pigmentosa with retinal nerve fiber layer thickening1177-54671177-5483https://doaj.org/article/e6b9e8da4bbe4ad6b8a6eed1fe96bc4f2012-03-01T00:00:00Zhttp://www.dovepress.com/cone-dysfunctions-in-retinitis-pigmentosa-with-retinal-nerve-fiber-lay-a9551https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Güngör Sobaci, Gökhan Özge, Fatih Ç GündoğanDepartment of Ophthalmology, Gülhane Military Medical Academy and Medical School, Etlik, Ankara, TurkeyPurpose: To investigate whether or not thicker retinal nerve fiber layer (RNFL) in retinitis pigmentosa (RP) patients relates to functional abnormalities of the photoreceptors.Methods: Optical coherence tomography-based RNFL thickness was measured by Stratus-3™ (Zeiss, Basel, Switzerland) optical coherence tomography and electroretinogram (ERG) recordings made using the RETI-port® system (Roland, Wiesbaden, Germany) in 27 patients with retinitis pigmentosa and in 30 healthy subjects.Results: Photopic ERG b-wave amplitude, cone ERG b-wave latency, 30 Hz flicker amplitude, and 30 Hz flicker latency had significant correlations to the RNFL-temporal (r = —0.55, P = 0.004, r = 0.68, P = 0.001, r = —0.65, P = 0.001, and r = —0.52, P = 0.007, respectively). Eyes with thicker RNFL (ten eyes) differed significantly from those with thinner RNFL (eight eyes) regarding cone ERG b-wave latency values only (P = 0.001).  Conclusion: Thicker RNFL in patients with retinitis pigmentosa may be associated with functional abnormality of the cone system.Keywords: optical coherence tomography, electroretinography, photoreceptor, b-waveSobaci GÖzge GGündoğan FÇDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 473-478 (2012)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Sobaci G
Özge G
Gündoğan FÇ
Cone dysfunctions in retinitis pigmentosa with retinal nerve fiber layer thickening
description Güngör Sobaci, Gökhan Özge, Fatih Ç GündoğanDepartment of Ophthalmology, Gülhane Military Medical Academy and Medical School, Etlik, Ankara, TurkeyPurpose: To investigate whether or not thicker retinal nerve fiber layer (RNFL) in retinitis pigmentosa (RP) patients relates to functional abnormalities of the photoreceptors.Methods: Optical coherence tomography-based RNFL thickness was measured by Stratus-3™ (Zeiss, Basel, Switzerland) optical coherence tomography and electroretinogram (ERG) recordings made using the RETI-port® system (Roland, Wiesbaden, Germany) in 27 patients with retinitis pigmentosa and in 30 healthy subjects.Results: Photopic ERG b-wave amplitude, cone ERG b-wave latency, 30 Hz flicker amplitude, and 30 Hz flicker latency had significant correlations to the RNFL-temporal (r = —0.55, P = 0.004, r = 0.68, P = 0.001, r = —0.65, P = 0.001, and r = —0.52, P = 0.007, respectively). Eyes with thicker RNFL (ten eyes) differed significantly from those with thinner RNFL (eight eyes) regarding cone ERG b-wave latency values only (P = 0.001).  Conclusion: Thicker RNFL in patients with retinitis pigmentosa may be associated with functional abnormality of the cone system.Keywords: optical coherence tomography, electroretinography, photoreceptor, b-wave
format article
author Sobaci G
Özge G
Gündoğan FÇ
author_facet Sobaci G
Özge G
Gündoğan FÇ
author_sort Sobaci G
title Cone dysfunctions in retinitis pigmentosa with retinal nerve fiber layer thickening
title_short Cone dysfunctions in retinitis pigmentosa with retinal nerve fiber layer thickening
title_full Cone dysfunctions in retinitis pigmentosa with retinal nerve fiber layer thickening
title_fullStr Cone dysfunctions in retinitis pigmentosa with retinal nerve fiber layer thickening
title_full_unstemmed Cone dysfunctions in retinitis pigmentosa with retinal nerve fiber layer thickening
title_sort cone dysfunctions in retinitis pigmentosa with retinal nerve fiber layer thickening
publisher Dove Medical Press
publishDate 2012
url https://doaj.org/article/e6b9e8da4bbe4ad6b8a6eed1fe96bc4f
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