Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein

Rabies virus (RABV) infection of unvaccinated individuals can be treated with post exposure prophylaxis. Here, Hellert et al. analyze the structure of a broadly neutralizing human antibody in complex with its target domain in the RABV glycoprotein and demonstrate that it blocks the acid-induced conf...

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Autores principales:	Jan Hellert, Julian Buchrieser, Florence Larrous, Andrea Minola, Guilherme Dias de Melo, Leah Soriaga, Patrick England, Ahmed Haouz, Amalio Telenti, Olivier Schwartz, Davide Corti, Hervé Bourhy, Félix A. Rey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6bafc79f9814357b005d33b29f35294
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spelling	oai:doaj.org-article:e6bafc79f9814357b005d33b29f352942021-12-02T14:40:51ZStructure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein10.1038/s41467-020-14398-72041-1723https://doaj.org/article/e6bafc79f9814357b005d33b29f352942020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14398-7https://doaj.org/toc/2041-1723Rabies virus (RABV) infection of unvaccinated individuals can be treated with post exposure prophylaxis. Here, Hellert et al. analyze the structure of a broadly neutralizing human antibody in complex with its target domain in the RABV glycoprotein and demonstrate that it blocks the acid-induced conformational change required for membrane fusion.Jan HellertJulian BuchrieserFlorence LarrousAndrea MinolaGuilherme Dias de MeloLeah SoriagaPatrick EnglandAhmed HaouzAmalio TelentiOlivier SchwartzDavide CortiHervé BourhyFélix A. ReyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jan Hellert Julian Buchrieser Florence Larrous Andrea Minola Guilherme Dias de Melo Leah Soriaga Patrick England Ahmed Haouz Amalio Telenti Olivier Schwartz Davide Corti Hervé Bourhy Félix A. Rey Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein
description	Rabies virus (RABV) infection of unvaccinated individuals can be treated with post exposure prophylaxis. Here, Hellert et al. analyze the structure of a broadly neutralizing human antibody in complex with its target domain in the RABV glycoprotein and demonstrate that it blocks the acid-induced conformational change required for membrane fusion.
format	article
author	Jan Hellert Julian Buchrieser Florence Larrous Andrea Minola Guilherme Dias de Melo Leah Soriaga Patrick England Ahmed Haouz Amalio Telenti Olivier Schwartz Davide Corti Hervé Bourhy Félix A. Rey
author_facet	Jan Hellert Julian Buchrieser Florence Larrous Andrea Minola Guilherme Dias de Melo Leah Soriaga Patrick England Ahmed Haouz Amalio Telenti Olivier Schwartz Davide Corti Hervé Bourhy Félix A. Rey
author_sort	Jan Hellert
title	Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein
title_short	Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein
title_full	Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein
title_fullStr	Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein
title_full_unstemmed	Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein
title_sort	structure of the prefusion-locking broadly neutralizing antibody rvc20 bound to the rabies virus glycoprotein
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e6bafc79f9814357b005d33b29f35294
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Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein

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