Mycobacterial DnaB helicase intein as oxidative stress sensor

Inteins can act as post-translational environmental sensors in vivo. Here the authors characterize two inteins present in the Mycobacterium smegmatis replicative helicase DnaB that display distinct splicing behaviors and are differentially sensitive to inhibition by biological stressors and propose...

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Autores principales:	Danielle S. Kelley, Christopher W. Lennon, Zhong Li, Michael R. Miller, Nilesh K. Banavali, Hongmin Li, Marlene Belfort
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6bf8fe10fa74715b24f6653ba8cb759
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spelling	oai:doaj.org-article:e6bf8fe10fa74715b24f6653ba8cb7592021-12-02T14:39:04ZMycobacterial DnaB helicase intein as oxidative stress sensor10.1038/s41467-018-06554-x2041-1723https://doaj.org/article/e6bf8fe10fa74715b24f6653ba8cb7592018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06554-xhttps://doaj.org/toc/2041-1723Inteins can act as post-translational environmental sensors in vivo. Here the authors characterize two inteins present in the Mycobacterium smegmatis replicative helicase DnaB that display distinct splicing behaviors and are differentially sensitive to inhibition by biological stressors and propose that splicing inhibition could modulate DnaB levels to protect the cell against replication stress.Danielle S. KelleyChristopher W. LennonZhong LiMichael R. MillerNilesh K. BanavaliHongmin LiMarlene BelfortNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Danielle S. Kelley Christopher W. Lennon Zhong Li Michael R. Miller Nilesh K. Banavali Hongmin Li Marlene Belfort Mycobacterial DnaB helicase intein as oxidative stress sensor
description	Inteins can act as post-translational environmental sensors in vivo. Here the authors characterize two inteins present in the Mycobacterium smegmatis replicative helicase DnaB that display distinct splicing behaviors and are differentially sensitive to inhibition by biological stressors and propose that splicing inhibition could modulate DnaB levels to protect the cell against replication stress.
format	article
author	Danielle S. Kelley Christopher W. Lennon Zhong Li Michael R. Miller Nilesh K. Banavali Hongmin Li Marlene Belfort
author_facet	Danielle S. Kelley Christopher W. Lennon Zhong Li Michael R. Miller Nilesh K. Banavali Hongmin Li Marlene Belfort
author_sort	Danielle S. Kelley
title	Mycobacterial DnaB helicase intein as oxidative stress sensor
title_short	Mycobacterial DnaB helicase intein as oxidative stress sensor
title_full	Mycobacterial DnaB helicase intein as oxidative stress sensor
title_fullStr	Mycobacterial DnaB helicase intein as oxidative stress sensor
title_full_unstemmed	Mycobacterial DnaB helicase intein as oxidative stress sensor
title_sort	mycobacterial dnab helicase intein as oxidative stress sensor
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e6bf8fe10fa74715b24f6653ba8cb759
work_keys_str_mv	AT danielleskelley mycobacterialdnabhelicaseinteinasoxidativestresssensor AT christopherwlennon mycobacterialdnabhelicaseinteinasoxidativestresssensor AT zhongli mycobacterialdnabhelicaseinteinasoxidativestresssensor AT michaelrmiller mycobacterialdnabhelicaseinteinasoxidativestresssensor AT nileshkbanavali mycobacterialdnabhelicaseinteinasoxidativestresssensor AT hongminli mycobacterialdnabhelicaseinteinasoxidativestresssensor AT marlenebelfort mycobacterialdnabhelicaseinteinasoxidativestresssensor
_version_	1718390804765999104

Mycobacterial DnaB helicase intein as oxidative stress sensor

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