Association Between ZNF804A Gene rs1344706 Polymorphism and Brain Functions in Healthy Individuals: A Systematic Review and Voxel-Based Meta-Analysis

Liqiong Yang,1 Fan Xu,2 Yi He,3 Yanzhang Li,4 Zi Chen,4 Shuai Wang4 1Department of Pharmacy, Chengdu Medical College, Chengdu, 610500, People’s Republic of China; 2Department of Public Health, Chengdu Medical College, Chengdu, 610500, People’s Republic of China; 3Department of Medicine, National Eng...

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Autores principales:	Yang L, Xu F, He Y, Li Y, Chen Z, Wang S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	functional magnetic resonance imaging zinc finger protein 804a meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e6c0a2b6b9c347ef80727ba98460deba
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spelling	oai:doaj.org-article:e6c0a2b6b9c347ef80727ba98460deba2021-12-02T17:24:59ZAssociation Between ZNF804A Gene rs1344706 Polymorphism and Brain Functions in Healthy Individuals: A Systematic Review and Voxel-Based Meta-Analysis1178-2021https://doaj.org/article/e6c0a2b6b9c347ef80727ba98460deba2021-09-01T00:00:00Zhttps://www.dovepress.com/association-between-znf804a-gene-rs1344706-polymorphism-and-brain-func-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Liqiong Yang,1 Fan Xu,2 Yi He,3 Yanzhang Li,4 Zi Chen,4 Shuai Wang4 1Department of Pharmacy, Chengdu Medical College, Chengdu, 610500, People’s Republic of China; 2Department of Public Health, Chengdu Medical College, Chengdu, 610500, People’s Republic of China; 3Department of Medicine, National Engineering and Research Center for Natural Medicines, Chengdu, 610400, People’s Republic of China; 4Department of Psychology, Chengdu Medical College, Chengdu, 610500, People’s Republic of ChinaCorrespondence: Shuai WangDepartment of Psychology, Chengdu Medical College, No. 783 Xindu Avenue, Chengdu, 610500, People’s Republic of ChinaTel +86 28 6273 9710Email wshuai86@126.comObjective: Zinc finger protein 804A (ZNF804A) protein participates in embryonic neural repair and development. The single nucleotide polymorphism rs1344706 in ZNF804A gene is closely related to functional abnormalities of the human brain. However, these results are inconsistent. This association was verified by meta-analysis in this study.Methods: Fifteen studies on functional magnetic resonance imaging involving 1710 healthy individuals were included in the systematic review and meta-analysis used by Anisotropic Effect-Size Signed Differential Mapping software.Results: Functional connectivity of the right dorsolateral prefrontal cortex (rDLPFC)–left hippocampus in the rs1344706 risk allele carrier was significantly increased (z = 2.066, p < 0.001), while those in the rDLPFC–left middle frontal gyrus (z = − 1.420, p < 0.001) and rDLPFC–right middle frontal gyrus (z = − 1.298, p < 0.001) were significantly decreased. Neural activity of the left anterior cingulate gyrus in the rs1344706 risk allele carrier was significantly decreased (z = − 2.525, p < 0.001). Sensitivity analysis was almost stable, and no publication bias was found.Conclusion: The changes in brain function have a clear correlation with ZNF804A gene in healthy individuals, which indicate the contribution of genetic variants on brain dysfunction.Registration Number: This meta-analysis is registered in PROSPERO (No. CRD42016051331).Keywords: functional magnetic resonance imaging, zinc finger protein 804A, meta-analysisYang LXu FHe YLi YChen ZWang SDove Medical Pressarticlefunctional magnetic resonance imagingzinc finger protein 804ameta-analysisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 2925-2935 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	functional magnetic resonance imaging zinc finger protein 804a meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	functional magnetic resonance imaging zinc finger protein 804a meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yang L Xu F He Y Li Y Chen Z Wang S Association Between ZNF804A Gene rs1344706 Polymorphism and Brain Functions in Healthy Individuals: A Systematic Review and Voxel-Based Meta-Analysis
description	Liqiong Yang,1 Fan Xu,2 Yi He,3 Yanzhang Li,4 Zi Chen,4 Shuai Wang4 1Department of Pharmacy, Chengdu Medical College, Chengdu, 610500, People’s Republic of China; 2Department of Public Health, Chengdu Medical College, Chengdu, 610500, People’s Republic of China; 3Department of Medicine, National Engineering and Research Center for Natural Medicines, Chengdu, 610400, People’s Republic of China; 4Department of Psychology, Chengdu Medical College, Chengdu, 610500, People’s Republic of ChinaCorrespondence: Shuai WangDepartment of Psychology, Chengdu Medical College, No. 783 Xindu Avenue, Chengdu, 610500, People’s Republic of ChinaTel +86 28 6273 9710Email wshuai86@126.comObjective: Zinc finger protein 804A (ZNF804A) protein participates in embryonic neural repair and development. The single nucleotide polymorphism rs1344706 in ZNF804A gene is closely related to functional abnormalities of the human brain. However, these results are inconsistent. This association was verified by meta-analysis in this study.Methods: Fifteen studies on functional magnetic resonance imaging involving 1710 healthy individuals were included in the systematic review and meta-analysis used by Anisotropic Effect-Size Signed Differential Mapping software.Results: Functional connectivity of the right dorsolateral prefrontal cortex (rDLPFC)–left hippocampus in the rs1344706 risk allele carrier was significantly increased (z = 2.066, p < 0.001), while those in the rDLPFC–left middle frontal gyrus (z = − 1.420, p < 0.001) and rDLPFC–right middle frontal gyrus (z = − 1.298, p < 0.001) were significantly decreased. Neural activity of the left anterior cingulate gyrus in the rs1344706 risk allele carrier was significantly decreased (z = − 2.525, p < 0.001). Sensitivity analysis was almost stable, and no publication bias was found.Conclusion: The changes in brain function have a clear correlation with ZNF804A gene in healthy individuals, which indicate the contribution of genetic variants on brain dysfunction.Registration Number: This meta-analysis is registered in PROSPERO (No. CRD42016051331).Keywords: functional magnetic resonance imaging, zinc finger protein 804A, meta-analysis
format	article
author	Yang L Xu F He Y Li Y Chen Z Wang S
author_facet	Yang L Xu F He Y Li Y Chen Z Wang S
author_sort	Yang L
title	Association Between ZNF804A Gene rs1344706 Polymorphism and Brain Functions in Healthy Individuals: A Systematic Review and Voxel-Based Meta-Analysis
title_short	Association Between ZNF804A Gene rs1344706 Polymorphism and Brain Functions in Healthy Individuals: A Systematic Review and Voxel-Based Meta-Analysis
title_full	Association Between ZNF804A Gene rs1344706 Polymorphism and Brain Functions in Healthy Individuals: A Systematic Review and Voxel-Based Meta-Analysis
title_fullStr	Association Between ZNF804A Gene rs1344706 Polymorphism and Brain Functions in Healthy Individuals: A Systematic Review and Voxel-Based Meta-Analysis
title_full_unstemmed	Association Between ZNF804A Gene rs1344706 Polymorphism and Brain Functions in Healthy Individuals: A Systematic Review and Voxel-Based Meta-Analysis
title_sort	association between znf804a gene rs1344706 polymorphism and brain functions in healthy individuals: a systematic review and voxel-based meta-analysis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e6c0a2b6b9c347ef80727ba98460deba
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Association Between ZNF804A Gene rs1344706 Polymorphism and Brain Functions in Healthy Individuals: A Systematic Review and Voxel-Based Meta-Analysis

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