Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds

Genomic studies of canine tumours have been done for individual cancer types or dog breeds. Here the authors analyse canine tumour genomics data across multiple breeds and cancer types, finding that mutational burden is associated with TP53 mutations and that Golden Retrievers are enriched for parti...

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Autores principales:	Burair A. Alsaihati, Kun-Lin Ho, Joshua Watson, Yuan Feng, Tianfang Wang, Kevin K. Dobbin, Shaying Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6c541ef0f1e4b92a51650df14158fb0
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spelling	oai:doaj.org-article:e6c541ef0f1e4b92a51650df14158fb02021-12-02T16:34:05ZCanine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds10.1038/s41467-021-24836-92041-1723https://doaj.org/article/e6c541ef0f1e4b92a51650df14158fb02021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24836-9https://doaj.org/toc/2041-1723Genomic studies of canine tumours have been done for individual cancer types or dog breeds. Here the authors analyse canine tumour genomics data across multiple breeds and cancer types, finding that mutational burden is associated with TP53 mutations and that Golden Retrievers are enriched for particular signatures.Burair A. AlsaihatiKun-Lin HoJoshua WatsonYuan FengTianfang WangKevin K. DobbinShaying ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Burair A. Alsaihati Kun-Lin Ho Joshua Watson Yuan Feng Tianfang Wang Kevin K. Dobbin Shaying Zhao Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds
description	Genomic studies of canine tumours have been done for individual cancer types or dog breeds. Here the authors analyse canine tumour genomics data across multiple breeds and cancer types, finding that mutational burden is associated with TP53 mutations and that Golden Retrievers are enriched for particular signatures.
format	article
author	Burair A. Alsaihati Kun-Lin Ho Joshua Watson Yuan Feng Tianfang Wang Kevin K. Dobbin Shaying Zhao
author_facet	Burair A. Alsaihati Kun-Lin Ho Joshua Watson Yuan Feng Tianfang Wang Kevin K. Dobbin Shaying Zhao
author_sort	Burair A. Alsaihati
title	Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds
title_short	Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds
title_full	Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds
title_fullStr	Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds
title_full_unstemmed	Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds
title_sort	canine tumor mutational burden is correlated with tp53 mutation across tumor types and breeds
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e6c541ef0f1e4b92a51650df14158fb0
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Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds

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