Association between myocardial triglyceride content and cardiac function in healthy subjects and endurance athletes.

Ectopic fat accumulation plays important roles in various metabolic disorders and cardiovascular diseases. Recent studies reported that myocardial triglyceride (TG) content measured by proton magnetic resonance spectroscopy ((1)H-MRS) is associated with aging, diabetes mellitus, and cardiac dysfunct...

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Autores principales: Eiryu Sai, Kazunori Shimada, Takayuki Yokoyama, Shuji Sato, Tetsuro Miyazaki, Makoto Hiki, Yoshifumi Tamura, Shigeki Aoki, Hirotaka Watada, Ryuzo Kawamori, Hiroyuki Daida
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Publicado: Public Library of Science (PLoS) 2013
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spelling oai:doaj.org-article:e6c61ebeb80546c99b68d19ffba7fb1a2021-11-18T07:49:19ZAssociation between myocardial triglyceride content and cardiac function in healthy subjects and endurance athletes.1932-620310.1371/journal.pone.0061604https://doaj.org/article/e6c61ebeb80546c99b68d19ffba7fb1a2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23613879/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Ectopic fat accumulation plays important roles in various metabolic disorders and cardiovascular diseases. Recent studies reported that myocardial triglyceride (TG) content measured by proton magnetic resonance spectroscopy ((1)H-MRS) is associated with aging, diabetes mellitus, and cardiac dysfunction. However, myocardial TG content in athletes has not yet been investigated. We performed (1)H-MRS and cardiac magnetic resonance imaging in 10 male endurance athletes and 15 healthy male controls. Serum markers and other clinical parameters including arterial stiffness were measured. Cardiopulmonary exercise testing was also performed. There were no significant differences in clinical characteristics including age, anthropometric parameters, blood test results, or arterial stiffness between the two groups. Peak oxygen uptakes, end-diastolic volume (EDV), end-systolic volume (ESV), left ventricular (LV) mass, peak ejection rates and peak filling rates were significantly higher in the athlete group than in the control group (all P<0.02). Myocardial TG content was significantly lower in the athlete group than in the control group (0.60 ± 0.20 vs. 0.89 ± 0.41%, P<0.05). Myocardial TG content was negatively correlated with EDV (r = -0.47), ESV (r = -0.64), LV mass (r = -0.44), and epicardial fat volume (r = 0.47) (all P<0.05). In conclusion, lower levels of myocardial TG content were observed in endurance athletes and were associated with morphological changes related to physiological LV alteration in athletes, suggesting that metabolic imaging for measurement of myocardial TG content by (1)H-MRS may be a useful technique for noninvasively assessing the "athlete's heart".Eiryu SaiKazunori ShimadaTakayuki YokoyamaShuji SatoTetsuro MiyazakiMakoto HikiYoshifumi TamuraShigeki AokiHirotaka WatadaRyuzo KawamoriHiroyuki DaidaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e61604 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Eiryu Sai
Kazunori Shimada
Takayuki Yokoyama
Shuji Sato
Tetsuro Miyazaki
Makoto Hiki
Yoshifumi Tamura
Shigeki Aoki
Hirotaka Watada
Ryuzo Kawamori
Hiroyuki Daida
Association between myocardial triglyceride content and cardiac function in healthy subjects and endurance athletes.
description Ectopic fat accumulation plays important roles in various metabolic disorders and cardiovascular diseases. Recent studies reported that myocardial triglyceride (TG) content measured by proton magnetic resonance spectroscopy ((1)H-MRS) is associated with aging, diabetes mellitus, and cardiac dysfunction. However, myocardial TG content in athletes has not yet been investigated. We performed (1)H-MRS and cardiac magnetic resonance imaging in 10 male endurance athletes and 15 healthy male controls. Serum markers and other clinical parameters including arterial stiffness were measured. Cardiopulmonary exercise testing was also performed. There were no significant differences in clinical characteristics including age, anthropometric parameters, blood test results, or arterial stiffness between the two groups. Peak oxygen uptakes, end-diastolic volume (EDV), end-systolic volume (ESV), left ventricular (LV) mass, peak ejection rates and peak filling rates were significantly higher in the athlete group than in the control group (all P<0.02). Myocardial TG content was significantly lower in the athlete group than in the control group (0.60 ± 0.20 vs. 0.89 ± 0.41%, P<0.05). Myocardial TG content was negatively correlated with EDV (r = -0.47), ESV (r = -0.64), LV mass (r = -0.44), and epicardial fat volume (r = 0.47) (all P<0.05). In conclusion, lower levels of myocardial TG content were observed in endurance athletes and were associated with morphological changes related to physiological LV alteration in athletes, suggesting that metabolic imaging for measurement of myocardial TG content by (1)H-MRS may be a useful technique for noninvasively assessing the "athlete's heart".
format article
author Eiryu Sai
Kazunori Shimada
Takayuki Yokoyama
Shuji Sato
Tetsuro Miyazaki
Makoto Hiki
Yoshifumi Tamura
Shigeki Aoki
Hirotaka Watada
Ryuzo Kawamori
Hiroyuki Daida
author_facet Eiryu Sai
Kazunori Shimada
Takayuki Yokoyama
Shuji Sato
Tetsuro Miyazaki
Makoto Hiki
Yoshifumi Tamura
Shigeki Aoki
Hirotaka Watada
Ryuzo Kawamori
Hiroyuki Daida
author_sort Eiryu Sai
title Association between myocardial triglyceride content and cardiac function in healthy subjects and endurance athletes.
title_short Association between myocardial triglyceride content and cardiac function in healthy subjects and endurance athletes.
title_full Association between myocardial triglyceride content and cardiac function in healthy subjects and endurance athletes.
title_fullStr Association between myocardial triglyceride content and cardiac function in healthy subjects and endurance athletes.
title_full_unstemmed Association between myocardial triglyceride content and cardiac function in healthy subjects and endurance athletes.
title_sort association between myocardial triglyceride content and cardiac function in healthy subjects and endurance athletes.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/e6c61ebeb80546c99b68d19ffba7fb1a
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