Clozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressor

Objective. Prolonged treatment with neuroleptics has been shown to induce FosB/ΔFosB expression in several brain regions including the medial prefrontal cortex, dorsomedial and dorsolateral striatum, ventrolateral and dorsolateral septum, nucleus accumbens shell and core, and the hypothalamic parave...

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Auteurs principaux:	Osacka Jana, Horvathova Lubica, Cernackova Alena, Kiss Alexander
Format:	article
Langue:	EN
Publié:	Sciendo 2019
Sujets:	clozapine acute and novel stress chronic mild stress fosb/δfosb forebrain Diseases of the endocrine glands. Clinical endocrinology RC648-665
Accès en ligne:	https://doaj.org/article/e6c8a6dc6d644cc39b5a0970b4c23c84
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id	oai:doaj.org-article:e6c8a6dc6d644cc39b5a0970b4c23c84
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spelling	oai:doaj.org-article:e6c8a6dc6d644cc39b5a0970b4c23c842021-12-02T19:07:37ZClozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressor1336-032910.2478/enr-2019-0010https://doaj.org/article/e6c8a6dc6d644cc39b5a0970b4c23c842019-04-01T00:00:00Zhttps://doi.org/10.2478/enr-2019-0010https://doaj.org/toc/1336-0329Objective. Prolonged treatment with neuroleptics has been shown to induce FosB/ΔFosB expression in several brain regions including the medial prefrontal cortex, dorsomedial and dorsolateral striatum, ventrolateral and dorsolateral septum, nucleus accumbens shell and core, and the hypothalamic paraventricular nucleus (PVN). Some of these regions are known to be also stress responsive. This study was designed to determine whether repeated clozapine (CLZ) administration for 7 consecutive days to Wistar rats may modify FosB/ΔFosB expression in the above-mentioned brain areas induced by acute stress or novel stressor that followed 13-day chronic mild stress preconditioning.Osacka JanaHorvathova LubicaCernackova AlenaKiss AlexanderSciendoarticleclozapineacute and novel stresschronic mild stressfosb/δfosbforebrainDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 53, Iss 2, Pp 83-92 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	clozapine acute and novel stress chronic mild stress fosb/δfosb forebrain Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	clozapine acute and novel stress chronic mild stress fosb/δfosb forebrain Diseases of the endocrine glands. Clinical endocrinology RC648-665 Osacka Jana Horvathova Lubica Cernackova Alena Kiss Alexander Clozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressor
description	Objective. Prolonged treatment with neuroleptics has been shown to induce FosB/ΔFosB expression in several brain regions including the medial prefrontal cortex, dorsomedial and dorsolateral striatum, ventrolateral and dorsolateral septum, nucleus accumbens shell and core, and the hypothalamic paraventricular nucleus (PVN). Some of these regions are known to be also stress responsive. This study was designed to determine whether repeated clozapine (CLZ) administration for 7 consecutive days to Wistar rats may modify FosB/ΔFosB expression in the above-mentioned brain areas induced by acute stress or novel stressor that followed 13-day chronic mild stress preconditioning.
format	article
author	Osacka Jana Horvathova Lubica Cernackova Alena Kiss Alexander
author_facet	Osacka Jana Horvathova Lubica Cernackova Alena Kiss Alexander
author_sort	Osacka Jana
title	Clozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressor
title_short	Clozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressor
title_full	Clozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressor
title_fullStr	Clozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressor
title_full_unstemmed	Clozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressor
title_sort	clozapine impact on fosb/δfosb expression in stress preconditioned rats: response to a novel stressor
publisher	Sciendo
publishDate	2019
url	https://doaj.org/article/e6c8a6dc6d644cc39b5a0970b4c23c84
work_keys_str_mv	AT osackajana clozapineimpactonfosbdfosbexpressioninstresspreconditionedratsresponsetoanovelstressor AT horvathovalubica clozapineimpactonfosbdfosbexpressioninstresspreconditionedratsresponsetoanovelstressor AT cernackovaalena clozapineimpactonfosbdfosbexpressioninstresspreconditionedratsresponsetoanovelstressor AT kissalexander clozapineimpactonfosbdfosbexpressioninstresspreconditionedratsresponsetoanovelstressor
_version_	1718377182407950336

Clozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressor

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