In vivo assessment of changes in corneal hysteresis and lamina cribrosa position during acute intraocular pressure elevation in eyes with markedly asymmetrical glaucoma

Corrado Gizzi, Mauro Cellini, Emilio C Campos Department of Experimental, Diagnostic and Speciality Medicine, Ophthalmology Service, University of Bologna, Bologna, Italy Purpose: To investigate the biomechanical response of the cornea, lamina cribrosa (LC), and prelaminar tissue (PT) to an acute...

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Autores principales:	Gizzi C, Cellini M, Campos EC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Asymmetrical glaucoma lamina cribrosa corneal hysteresis corneal resistance factor Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/e6cb3b78d4824263af8a16cb90db7ee0
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spelling	oai:doaj.org-article:e6cb3b78d4824263af8a16cb90db7ee02021-12-02T02:31:34ZIn vivo assessment of changes in corneal hysteresis and lamina cribrosa position during acute intraocular pressure elevation in eyes with markedly asymmetrical glaucoma1177-5483https://doaj.org/article/e6cb3b78d4824263af8a16cb90db7ee02018-03-01T00:00:00Zhttps://www.dovepress.com/in-vivo-assessment-of-changes-in-corneal-hysteresis-and-lamina-cribros-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Corrado Gizzi, Mauro Cellini, Emilio C Campos Department of Experimental, Diagnostic and Speciality Medicine, Ophthalmology Service, University of Bologna, Bologna, Italy Purpose: To investigate the biomechanical response of the cornea, lamina cribrosa (LC), and prelaminar tissue (PT) to an acute intraocular pressure (IOP) increase in patients with markedly asymmetrical glaucoma and in healthy controls.Patients and methods: A total of 24 eyes of 12 patients with markedly asymmetrical primary open-angle glaucoma (POAG) and 12 eyes of 12 healthy patients were examined with spectral-domain optical coherence tomography (SD-OCT) and ocular response analyzer (ORA) at baseline and during acute IOP elevation by means of an ophthalmodynamometer. The displacement of the LC and PT and the change in corneal hysteresis (CH) and corneal resistance factor (CRF) were evaluated.Results: Following a mean IOP increase of 12.3±2.4 mmHg, eyes with severe glaucoma demonstrated an overall mean anterior displacement of the LC (-6.58±26.09 µm) as opposed to the posterior laminar displacement in eyes with mild glaucoma (29.08±19.28 µm) and in healthy eyes (30.3±10.9; p≤0.001 and p=0.001, respectively). The PT displaced posteriorly during IOP elevation in all eyes. The CH decreased in eyes with severe glaucoma during IOP elevation (from 9.30±3.65 to 6.92±3.04 mmHg; p=0.012), whereas the CRF increased markedly in eyes with mild glaucoma (from 8.61±2.30 to 12.38±3.64; p=0.002) and in eyes with severe glaucoma (from 9.02±1.48 to 15.20±2.06; p=0.002). The increase in CRF correlated with the anterior displacement of the LC in eyes with severe glaucoma.Conclusion: Eyes with severe glaucoma exhibited a mean overall anterior displacement of the anterior laminar surface, while eyes with mild glaucoma and healthy eyes showed a posterior displacement of the LC during IOP elevation. The CH decreased significantly from baseline only in eyes with severe glaucoma, but the CRF increased significantly in all glaucomatous eyes. The CRF increase correlated with the anterior displacement of the LC in eyes with severe glaucoma. Keywords: glaucoma, lamina cribrosa, cornea, hysteresis, ophthalmodynamometer, biomechanics, asymmetry Gizzi CCellini MCampos ECDove Medical PressarticleAsymmetrical glaucomalamina cribrosacorneal hysteresiscorneal resistance factorOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 481-492 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Asymmetrical glaucoma lamina cribrosa corneal hysteresis corneal resistance factor Ophthalmology RE1-994
spellingShingle	Asymmetrical glaucoma lamina cribrosa corneal hysteresis corneal resistance factor Ophthalmology RE1-994 Gizzi C Cellini M Campos EC In vivo assessment of changes in corneal hysteresis and lamina cribrosa position during acute intraocular pressure elevation in eyes with markedly asymmetrical glaucoma
description	Corrado Gizzi, Mauro Cellini, Emilio C Campos Department of Experimental, Diagnostic and Speciality Medicine, Ophthalmology Service, University of Bologna, Bologna, Italy Purpose: To investigate the biomechanical response of the cornea, lamina cribrosa (LC), and prelaminar tissue (PT) to an acute intraocular pressure (IOP) increase in patients with markedly asymmetrical glaucoma and in healthy controls.Patients and methods: A total of 24 eyes of 12 patients with markedly asymmetrical primary open-angle glaucoma (POAG) and 12 eyes of 12 healthy patients were examined with spectral-domain optical coherence tomography (SD-OCT) and ocular response analyzer (ORA) at baseline and during acute IOP elevation by means of an ophthalmodynamometer. The displacement of the LC and PT and the change in corneal hysteresis (CH) and corneal resistance factor (CRF) were evaluated.Results: Following a mean IOP increase of 12.3±2.4 mmHg, eyes with severe glaucoma demonstrated an overall mean anterior displacement of the LC (-6.58±26.09 µm) as opposed to the posterior laminar displacement in eyes with mild glaucoma (29.08±19.28 µm) and in healthy eyes (30.3±10.9; p≤0.001 and p=0.001, respectively). The PT displaced posteriorly during IOP elevation in all eyes. The CH decreased in eyes with severe glaucoma during IOP elevation (from 9.30±3.65 to 6.92±3.04 mmHg; p=0.012), whereas the CRF increased markedly in eyes with mild glaucoma (from 8.61±2.30 to 12.38±3.64; p=0.002) and in eyes with severe glaucoma (from 9.02±1.48 to 15.20±2.06; p=0.002). The increase in CRF correlated with the anterior displacement of the LC in eyes with severe glaucoma.Conclusion: Eyes with severe glaucoma exhibited a mean overall anterior displacement of the anterior laminar surface, while eyes with mild glaucoma and healthy eyes showed a posterior displacement of the LC during IOP elevation. The CH decreased significantly from baseline only in eyes with severe glaucoma, but the CRF increased significantly in all glaucomatous eyes. The CRF increase correlated with the anterior displacement of the LC in eyes with severe glaucoma. Keywords: glaucoma, lamina cribrosa, cornea, hysteresis, ophthalmodynamometer, biomechanics, asymmetry
format	article
author	Gizzi C Cellini M Campos EC
author_facet	Gizzi C Cellini M Campos EC
author_sort	Gizzi C
title	In vivo assessment of changes in corneal hysteresis and lamina cribrosa position during acute intraocular pressure elevation in eyes with markedly asymmetrical glaucoma
title_short	In vivo assessment of changes in corneal hysteresis and lamina cribrosa position during acute intraocular pressure elevation in eyes with markedly asymmetrical glaucoma
title_full	In vivo assessment of changes in corneal hysteresis and lamina cribrosa position during acute intraocular pressure elevation in eyes with markedly asymmetrical glaucoma
title_fullStr	In vivo assessment of changes in corneal hysteresis and lamina cribrosa position during acute intraocular pressure elevation in eyes with markedly asymmetrical glaucoma
title_full_unstemmed	In vivo assessment of changes in corneal hysteresis and lamina cribrosa position during acute intraocular pressure elevation in eyes with markedly asymmetrical glaucoma
title_sort	in vivo assessment of changes in corneal hysteresis and lamina cribrosa position during acute intraocular pressure elevation in eyes with markedly asymmetrical glaucoma
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/e6cb3b78d4824263af8a16cb90db7ee0
work_keys_str_mv	AT gizzic invivoassessmentofchangesincornealhysteresisandlaminacribrosapositionduringacuteintraocularpressureelevationineyeswithmarkedlyasymmetricalglaucoma AT cellinim invivoassessmentofchangesincornealhysteresisandlaminacribrosapositionduringacuteintraocularpressureelevationineyeswithmarkedlyasymmetricalglaucoma AT camposec invivoassessmentofchangesincornealhysteresisandlaminacribrosapositionduringacuteintraocularpressureelevationineyeswithmarkedlyasymmetricalglaucoma
_version_	1718402445187481600

In vivo assessment of changes in corneal hysteresis and lamina cribrosa position during acute intraocular pressure elevation in eyes with markedly asymmetrical glaucoma

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