Values of ultrasound features and MMP-9 of papillary thyroid carcinoma in predicting cervical lymph node metastases

Abstract Preoperative assessment of the cervical lymph node status is important in therapeutic schedule and further evaluations of prognosis for papillary thyroid carcinoma (PTC) patients. Our aim was to investigate the diagnostic values of conventional ultrasound (US), contrast-enhanced ultrasound...

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Autores principales:	Yan Zhang, Yu-kun Luo, Ming-bo Zhang, Jie Li, Chang-tian Li, Jie Tang, Jun-lai Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e6cea7d394104b8abe27c158ce8c3aae
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spelling	oai:doaj.org-article:e6cea7d394104b8abe27c158ce8c3aae2021-12-02T11:40:21ZValues of ultrasound features and MMP-9 of papillary thyroid carcinoma in predicting cervical lymph node metastases10.1038/s41598-017-07118-72045-2322https://doaj.org/article/e6cea7d394104b8abe27c158ce8c3aae2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07118-7https://doaj.org/toc/2045-2322Abstract Preoperative assessment of the cervical lymph node status is important in therapeutic schedule and further evaluations of prognosis for papillary thyroid carcinoma (PTC) patients. Our aim was to investigate the diagnostic values of conventional ultrasound (US), contrast-enhanced ultrasound (CEUS) features and the expression of MMP-9 of PTC in predicting the cervical lymph node metastases (LNM). In total, 156 patients with PTC confirmed by surgical pathology were included. Seventy-one patients had cervical LNM, while 85 patients had no LNM. The patients had cervical LNM (39.51 ± 13.29 years) were younger than those had no LNM (44.15 ± 10.94 years) (P = 0.02). Multivariate logistic regression results showed that tumor size ≥0.95 cm (OR = 13.47), ill-defined margin (OR = 4.31), internal heterogeneous low-enhancement (OR = 5.19) and ECE (OR = 25.25) were predictive for the presence of cervical LNM. The detection rate of ECE for the PTC with LNM by CEUS (81.48%, 44/54) was higher than by US (46.30%, 25/54). There was significant difference in MMP-9 intensity between PTC with and without cervical LNM (P = 0.000), and intense reactions (+++) were mainly found in the PTCs with LNM (80.95%, 17/21). In conclusion, the combination of conventional US, CEUS features and MMP-9 expression may serve as an effective tool for predicting the cervical LNM of PTC.Yan ZhangYu-kun LuoMing-bo ZhangJie LiChang-tian LiJie TangJun-lai LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yan Zhang Yu-kun Luo Ming-bo Zhang Jie Li Chang-tian Li Jie Tang Jun-lai Li Values of ultrasound features and MMP-9 of papillary thyroid carcinoma in predicting cervical lymph node metastases
description	Abstract Preoperative assessment of the cervical lymph node status is important in therapeutic schedule and further evaluations of prognosis for papillary thyroid carcinoma (PTC) patients. Our aim was to investigate the diagnostic values of conventional ultrasound (US), contrast-enhanced ultrasound (CEUS) features and the expression of MMP-9 of PTC in predicting the cervical lymph node metastases (LNM). In total, 156 patients with PTC confirmed by surgical pathology were included. Seventy-one patients had cervical LNM, while 85 patients had no LNM. The patients had cervical LNM (39.51 ± 13.29 years) were younger than those had no LNM (44.15 ± 10.94 years) (P = 0.02). Multivariate logistic regression results showed that tumor size ≥0.95 cm (OR = 13.47), ill-defined margin (OR = 4.31), internal heterogeneous low-enhancement (OR = 5.19) and ECE (OR = 25.25) were predictive for the presence of cervical LNM. The detection rate of ECE for the PTC with LNM by CEUS (81.48%, 44/54) was higher than by US (46.30%, 25/54). There was significant difference in MMP-9 intensity between PTC with and without cervical LNM (P = 0.000), and intense reactions (+++) were mainly found in the PTCs with LNM (80.95%, 17/21). In conclusion, the combination of conventional US, CEUS features and MMP-9 expression may serve as an effective tool for predicting the cervical LNM of PTC.
format	article
author	Yan Zhang Yu-kun Luo Ming-bo Zhang Jie Li Chang-tian Li Jie Tang Jun-lai Li
author_facet	Yan Zhang Yu-kun Luo Ming-bo Zhang Jie Li Chang-tian Li Jie Tang Jun-lai Li
author_sort	Yan Zhang
title	Values of ultrasound features and MMP-9 of papillary thyroid carcinoma in predicting cervical lymph node metastases
title_short	Values of ultrasound features and MMP-9 of papillary thyroid carcinoma in predicting cervical lymph node metastases
title_full	Values of ultrasound features and MMP-9 of papillary thyroid carcinoma in predicting cervical lymph node metastases
title_fullStr	Values of ultrasound features and MMP-9 of papillary thyroid carcinoma in predicting cervical lymph node metastases
title_full_unstemmed	Values of ultrasound features and MMP-9 of papillary thyroid carcinoma in predicting cervical lymph node metastases
title_sort	values of ultrasound features and mmp-9 of papillary thyroid carcinoma in predicting cervical lymph node metastases
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e6cea7d394104b8abe27c158ce8c3aae
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Values of ultrasound features and MMP-9 of papillary thyroid carcinoma in predicting cervical lymph node metastases

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