Heritability and genome‐wide association study of blood pressure in Chinese adult twins

Abstract Background Blood pressure (BP) is an independent and important factor for chronic diseases such as cardiovascular diseases and diabetes. Methods We firstly conducted twin modeling analyses to explore the heritability of BP, including systolic blood pressure (SBP), diastolic blood pressure (...

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Autores principales:	Jiahao Chen, Weijing Wang, Zhaoying Li, Chunsheng Xu, Xiaocao Tian, Dongfeng Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	blood pressure GWAS heritability twins Genetics QH426-470
Acceso en línea:	https://doaj.org/article/e6cf3bd2eb2f4a5b9095520fe94ce878
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spelling	oai:doaj.org-article:e6cf3bd2eb2f4a5b9095520fe94ce8782021-11-21T19:38:53ZHeritability and genome‐wide association study of blood pressure in Chinese adult twins2324-926910.1002/mgg3.1828https://doaj.org/article/e6cf3bd2eb2f4a5b9095520fe94ce8782021-11-01T00:00:00Zhttps://doi.org/10.1002/mgg3.1828https://doaj.org/toc/2324-9269Abstract Background Blood pressure (BP) is an independent and important factor for chronic diseases such as cardiovascular diseases and diabetes. Methods We firstly conducted twin modeling analyses to explore the heritability of BP, including systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP) and mean arterial pressure (MAP), and then performed genome‐wide association studies to explore the associated genomic loci, genes, and pathways. Results A total of 380 Chinese twin pairs were included. The AE model containing additive genetic parameter (A) and unique/non‐shared environmental parameter (E) was the best fit model, with A accounting for 53.7%, 50.1%, 48.1%, and 53.3% for SBP, DBP, PP and MAP, respectively. No SNP was found to reach the genome‐wide significance level (p < 5 × 10−8), however, three, four, 14 and nine SNPs were found to exceed suggestive significance level (p < 1 × 10−5) for SBP, DBP, PP, and MAP, respectively. And after imputation, 46, 37, 91 and 61 SNPs were found to exceed the suggestive significance level for SBP, DBP, PP, and MAP, respectively. In gene‐based analysis, 53 common genes were found among SBP, DBP, PP, and MAP. In pathway enrichment analysis, 672, 706, 701, and 596 biological pathways were associated with SBP, DBP, PP, and MAP, respectively (p < 0.05). Conclusion Our study suggests that BP is moderately heritable in the Chinese population and could be mediated by a series of genomic loci, genes, and pathways. Future larger‐scale studies are needed to confirm our findings.Jiahao ChenWeijing WangZhaoying LiChunsheng XuXiaocao TianDongfeng ZhangWileyarticleblood pressureGWASheritabilitytwinsGeneticsQH426-470ENMolecular Genetics & Genomic Medicine, Vol 9, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood pressure GWAS heritability twins Genetics QH426-470
spellingShingle	blood pressure GWAS heritability twins Genetics QH426-470 Jiahao Chen Weijing Wang Zhaoying Li Chunsheng Xu Xiaocao Tian Dongfeng Zhang Heritability and genome‐wide association study of blood pressure in Chinese adult twins
description	Abstract Background Blood pressure (BP) is an independent and important factor for chronic diseases such as cardiovascular diseases and diabetes. Methods We firstly conducted twin modeling analyses to explore the heritability of BP, including systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP) and mean arterial pressure (MAP), and then performed genome‐wide association studies to explore the associated genomic loci, genes, and pathways. Results A total of 380 Chinese twin pairs were included. The AE model containing additive genetic parameter (A) and unique/non‐shared environmental parameter (E) was the best fit model, with A accounting for 53.7%, 50.1%, 48.1%, and 53.3% for SBP, DBP, PP and MAP, respectively. No SNP was found to reach the genome‐wide significance level (p < 5 × 10−8), however, three, four, 14 and nine SNPs were found to exceed suggestive significance level (p < 1 × 10−5) for SBP, DBP, PP, and MAP, respectively. And after imputation, 46, 37, 91 and 61 SNPs were found to exceed the suggestive significance level for SBP, DBP, PP, and MAP, respectively. In gene‐based analysis, 53 common genes were found among SBP, DBP, PP, and MAP. In pathway enrichment analysis, 672, 706, 701, and 596 biological pathways were associated with SBP, DBP, PP, and MAP, respectively (p < 0.05). Conclusion Our study suggests that BP is moderately heritable in the Chinese population and could be mediated by a series of genomic loci, genes, and pathways. Future larger‐scale studies are needed to confirm our findings.
format	article
author	Jiahao Chen Weijing Wang Zhaoying Li Chunsheng Xu Xiaocao Tian Dongfeng Zhang
author_facet	Jiahao Chen Weijing Wang Zhaoying Li Chunsheng Xu Xiaocao Tian Dongfeng Zhang
author_sort	Jiahao Chen
title	Heritability and genome‐wide association study of blood pressure in Chinese adult twins
title_short	Heritability and genome‐wide association study of blood pressure in Chinese adult twins
title_full	Heritability and genome‐wide association study of blood pressure in Chinese adult twins
title_fullStr	Heritability and genome‐wide association study of blood pressure in Chinese adult twins
title_full_unstemmed	Heritability and genome‐wide association study of blood pressure in Chinese adult twins
title_sort	heritability and genome‐wide association study of blood pressure in chinese adult twins
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/e6cf3bd2eb2f4a5b9095520fe94ce878
work_keys_str_mv	AT jiahaochen heritabilityandgenomewideassociationstudyofbloodpressureinchineseadulttwins AT weijingwang heritabilityandgenomewideassociationstudyofbloodpressureinchineseadulttwins AT zhaoyingli heritabilityandgenomewideassociationstudyofbloodpressureinchineseadulttwins AT chunshengxu heritabilityandgenomewideassociationstudyofbloodpressureinchineseadulttwins AT xiaocaotian heritabilityandgenomewideassociationstudyofbloodpressureinchineseadulttwins AT dongfengzhang heritabilityandgenomewideassociationstudyofbloodpressureinchineseadulttwins
_version_	1718418735931326464

Heritability and genome‐wide association study of blood pressure in Chinese adult twins

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