Mathematical modeling of tuberculosis bacillary counts and cellular populations in the organs of infected mice.

<h4>Background</h4>Mycobacterium tuberculosis is a particularly aggressive microorganism and the host's defense is based on the induction of cellular immunity, in which the creation of a granulomatous structure has an important role.<h4>Methodology</h4>We present here a...

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Autores principales:	Antonio Bru, Pere-Joan Cardona
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e6d1ef2ed90545a084ff5719e4cc3082
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spelling	oai:doaj.org-article:e6d1ef2ed90545a084ff5719e4cc30822021-11-18T06:34:51ZMathematical modeling of tuberculosis bacillary counts and cellular populations in the organs of infected mice.1932-620310.1371/journal.pone.0012985https://doaj.org/article/e6d1ef2ed90545a084ff5719e4cc30822010-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20886087/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Mycobacterium tuberculosis is a particularly aggressive microorganism and the host's defense is based on the induction of cellular immunity, in which the creation of a granulomatous structure has an important role.<h4>Methodology</h4>We present here a new 2D cellular automata model based on the concept of a multifunctional process that includes key factors such as the chemokine attraction of the cells; the role of innate immunity triggered by natural killers; the presence of neutrophils; apoptosis and necrosis of infected macrophages; the removal of dead cells by macrophages, which induces the production of foamy macrophages (FMs); the life cycle of the bacilli as a determinant for the evolution of infected macrophages; and the immune response.<h4>Results</h4>The results obtained after the inclusion of two degrees of tolerance to the inflammatory response triggered by the infection shows that the model can cover a wide spectrum, ranging from highly-tolerant (i.e. mice) to poorly-tolerant hosts (i.e. mini-pigs or humans).<h4>Conclusions</h4>This model suggest that stopping bacillary growth at the onset of the infection might be difficult and the important role played by FMs in bacillary drainage in poorly-tolerant hosts together with apoptosis and innate lymphocytes. It also shows the poor ability of the cellular immunity to control the infection, provides a clear protective character to the granuloma, due its ability to attract a sufficient number of cells, and explains why an already infected host can be constantly reinfected.Antonio BruPere-Joan CardonaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 9, p e12985 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antonio Bru Pere-Joan Cardona Mathematical modeling of tuberculosis bacillary counts and cellular populations in the organs of infected mice.
description	<h4>Background</h4>Mycobacterium tuberculosis is a particularly aggressive microorganism and the host's defense is based on the induction of cellular immunity, in which the creation of a granulomatous structure has an important role.<h4>Methodology</h4>We present here a new 2D cellular automata model based on the concept of a multifunctional process that includes key factors such as the chemokine attraction of the cells; the role of innate immunity triggered by natural killers; the presence of neutrophils; apoptosis and necrosis of infected macrophages; the removal of dead cells by macrophages, which induces the production of foamy macrophages (FMs); the life cycle of the bacilli as a determinant for the evolution of infected macrophages; and the immune response.<h4>Results</h4>The results obtained after the inclusion of two degrees of tolerance to the inflammatory response triggered by the infection shows that the model can cover a wide spectrum, ranging from highly-tolerant (i.e. mice) to poorly-tolerant hosts (i.e. mini-pigs or humans).<h4>Conclusions</h4>This model suggest that stopping bacillary growth at the onset of the infection might be difficult and the important role played by FMs in bacillary drainage in poorly-tolerant hosts together with apoptosis and innate lymphocytes. It also shows the poor ability of the cellular immunity to control the infection, provides a clear protective character to the granuloma, due its ability to attract a sufficient number of cells, and explains why an already infected host can be constantly reinfected.
format	article
author	Antonio Bru Pere-Joan Cardona
author_facet	Antonio Bru Pere-Joan Cardona
author_sort	Antonio Bru
title	Mathematical modeling of tuberculosis bacillary counts and cellular populations in the organs of infected mice.
title_short	Mathematical modeling of tuberculosis bacillary counts and cellular populations in the organs of infected mice.
title_full	Mathematical modeling of tuberculosis bacillary counts and cellular populations in the organs of infected mice.
title_fullStr	Mathematical modeling of tuberculosis bacillary counts and cellular populations in the organs of infected mice.
title_full_unstemmed	Mathematical modeling of tuberculosis bacillary counts and cellular populations in the organs of infected mice.
title_sort	mathematical modeling of tuberculosis bacillary counts and cellular populations in the organs of infected mice.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/e6d1ef2ed90545a084ff5719e4cc3082
work_keys_str_mv	AT antoniobru mathematicalmodelingoftuberculosisbacillarycountsandcellularpopulationsintheorgansofinfectedmice AT perejoancardona mathematicalmodelingoftuberculosisbacillarycountsandcellularpopulationsintheorgansofinfectedmice
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Mathematical modeling of tuberculosis bacillary counts and cellular populations in the organs of infected mice.

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