Epigenetic Mechanisms in Memory and Cognitive Decline Associated with Aging and Alzheimer’s Disease

Epigenetic mechanisms, which include DNA methylation, a variety of post-translational modifications of histone proteins (acetylation, phosphorylation, methylation, ubiquitination, sumoylation, serotonylation, dopaminylation), chromatin remodeling enzymes, and long non-coding RNAs, are robust regulat...

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Autores principales:	Sabyasachi Maity, Kayla Farrell, Shaghayegh Navabpour, Sareesh Naduvil Narayanan, Timothy J. Jarome
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	epigenetics DNA histone hippocampus memory neurodegeneration Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/e6d2cb0d52a34650a3e4e537b99a8cfa
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spelling	oai:doaj.org-article:e6d2cb0d52a34650a3e4e537b99a8cfa2021-11-25T17:55:00ZEpigenetic Mechanisms in Memory and Cognitive Decline Associated with Aging and Alzheimer’s Disease10.3390/ijms2222122801422-00671661-6596https://doaj.org/article/e6d2cb0d52a34650a3e4e537b99a8cfa2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12280https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Epigenetic mechanisms, which include DNA methylation, a variety of post-translational modifications of histone proteins (acetylation, phosphorylation, methylation, ubiquitination, sumoylation, serotonylation, dopaminylation), chromatin remodeling enzymes, and long non-coding RNAs, are robust regulators of activity-dependent changes in gene transcription. In the brain, many of these epigenetic modifications have been widely implicated in synaptic plasticity and memory formation. Dysregulation of epigenetic mechanisms has been reported in the aged brain and is associated with or contributes to memory decline across the lifespan. Furthermore, alterations in the epigenome have been reported in neurodegenerative disorders, including Alzheimer’s disease. Here, we review the diverse types of epigenetic modifications and their role in activity- and learning-dependent synaptic plasticity. We then discuss how these mechanisms become dysregulated across the lifespan and contribute to memory loss with age and in Alzheimer’s disease. Collectively, the evidence reviewed here strongly supports a role for diverse epigenetic mechanisms in memory formation, aging, and neurodegeneration in the brain.Sabyasachi MaityKayla FarrellShaghayegh NavabpourSareesh Naduvil NarayananTimothy J. JaromeMDPI AGarticleepigeneticsDNAhistonehippocampusmemoryneurodegenerationBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12280, p 12280 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epigenetics DNA histone hippocampus memory neurodegeneration Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	epigenetics DNA histone hippocampus memory neurodegeneration Biology (General) QH301-705.5 Chemistry QD1-999 Sabyasachi Maity Kayla Farrell Shaghayegh Navabpour Sareesh Naduvil Narayanan Timothy J. Jarome Epigenetic Mechanisms in Memory and Cognitive Decline Associated with Aging and Alzheimer’s Disease
description	Epigenetic mechanisms, which include DNA methylation, a variety of post-translational modifications of histone proteins (acetylation, phosphorylation, methylation, ubiquitination, sumoylation, serotonylation, dopaminylation), chromatin remodeling enzymes, and long non-coding RNAs, are robust regulators of activity-dependent changes in gene transcription. In the brain, many of these epigenetic modifications have been widely implicated in synaptic plasticity and memory formation. Dysregulation of epigenetic mechanisms has been reported in the aged brain and is associated with or contributes to memory decline across the lifespan. Furthermore, alterations in the epigenome have been reported in neurodegenerative disorders, including Alzheimer’s disease. Here, we review the diverse types of epigenetic modifications and their role in activity- and learning-dependent synaptic plasticity. We then discuss how these mechanisms become dysregulated across the lifespan and contribute to memory loss with age and in Alzheimer’s disease. Collectively, the evidence reviewed here strongly supports a role for diverse epigenetic mechanisms in memory formation, aging, and neurodegeneration in the brain.
format	article
author	Sabyasachi Maity Kayla Farrell Shaghayegh Navabpour Sareesh Naduvil Narayanan Timothy J. Jarome
author_facet	Sabyasachi Maity Kayla Farrell Shaghayegh Navabpour Sareesh Naduvil Narayanan Timothy J. Jarome
author_sort	Sabyasachi Maity
title	Epigenetic Mechanisms in Memory and Cognitive Decline Associated with Aging and Alzheimer’s Disease
title_short	Epigenetic Mechanisms in Memory and Cognitive Decline Associated with Aging and Alzheimer’s Disease
title_full	Epigenetic Mechanisms in Memory and Cognitive Decline Associated with Aging and Alzheimer’s Disease
title_fullStr	Epigenetic Mechanisms in Memory and Cognitive Decline Associated with Aging and Alzheimer’s Disease
title_full_unstemmed	Epigenetic Mechanisms in Memory and Cognitive Decline Associated with Aging and Alzheimer’s Disease
title_sort	epigenetic mechanisms in memory and cognitive decline associated with aging and alzheimer’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e6d2cb0d52a34650a3e4e537b99a8cfa
work_keys_str_mv	AT sabyasachimaity epigeneticmechanismsinmemoryandcognitivedeclineassociatedwithagingandalzheimersdisease AT kaylafarrell epigeneticmechanismsinmemoryandcognitivedeclineassociatedwithagingandalzheimersdisease AT shaghayeghnavabpour epigeneticmechanismsinmemoryandcognitivedeclineassociatedwithagingandalzheimersdisease AT sareeshnaduvilnarayanan epigeneticmechanismsinmemoryandcognitivedeclineassociatedwithagingandalzheimersdisease AT timothyjjarome epigeneticmechanismsinmemoryandcognitivedeclineassociatedwithagingandalzheimersdisease
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Epigenetic Mechanisms in Memory and Cognitive Decline Associated with Aging and Alzheimer’s Disease

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