A pilot study of serotonin-1A receptor genotypes and rapid eye movement sleep sensitivity to serotonergic/cholinergic imbalance in humans: a pharmacological model of depression

Kathleen Biard,1,2 Alan B Douglass,2,3 Rébecca Robillard,2 Joseph De Koninck1,2 1School of Psychology, University of Ottawa, 2University of Ottawa Institute for Mental Health Research, 3Royal Ottawa Mental Health Center, University of Ottawa Institute for Mental Health Research, Ottawa, O...

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Autores principales: Biard K, Douglass AB, Robillard R, De Koninck J
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Publicado: Dove Medical Press 2015
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spelling oai:doaj.org-article:e6d4381410e1415e91b694e88ff6981b2021-12-02T00:18:20ZA pilot study of serotonin-1A receptor genotypes and rapid eye movement sleep sensitivity to serotonergic/cholinergic imbalance in humans: a pharmacological model of depression1179-1608https://doaj.org/article/e6d4381410e1415e91b694e88ff6981b2015-12-01T00:00:00Zhttps://www.dovepress.com/a-pilot-study-of-serotonin-1a-receptor-genotypes-and-rapid-eye-movemen-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Kathleen Biard,1,2 Alan B Douglass,2,3 Rébecca Robillard,2 Joseph De Koninck1,2 1School of Psychology, University of Ottawa, 2University of Ottawa Institute for Mental Health Research, 3Royal Ottawa Mental Health Center, University of Ottawa Institute for Mental Health Research, Ottawa, ON, Canada Rationale: The serotonergic and cholinergic systems are jointly involved in regulating sleep but this system is theorized to be disturbed in depressed individuals. We previously reported that cholinergic and serotonergic agents induce sleep changes partially consistent with monoamine models of sleep disturbances in depression. One potential cause of disturbed neurotransmission is genetic predisposition. The G(-1019) allele of the serotonin-1A (5-HT1A) receptor promoter region predicts an increased risk for depression compared to the wild-type C(-1019) allele. Objective: The goal of this study was to investigate how serotonin-1A receptor genotypes mediate sleep sensitivity to pharmacological probes modeling the serotonergic/cholinergic imbalance of depression. Methods: Seventeen healthy female participants homozygous for either C (n=11) or G (n=6) alleles aged 18–27 years were tested on four nonconsecutive nights. Participants were given galantamine (an anti-acetylcholinesterase), buspirone (a serotonergic agonist), both drugs together, or placebos before sleeping. Results: As reported previously, buspirone significantly increased rapid eye movement (REM) latency (P<0.001), as well as awakenings, percentage of time spent awake, and percentage of time asleep spent in stage N1 (P<0.019). Galantamine increased awakenings, percentage of time spent awake, percentage of time asleep spent in stage N1, and percentage of time asleep spent in REM, and decreased REM latency and percentage of time asleep spent in stage N3 (P<0.019). Galantamine plus buspirone given together disrupted sleep more than either drug alone, lowering sleep efficiency and percentage of time asleep spent in stage N3 and increasing awakenings, percentage of time spent awake, and percentage of time asleep spent in stage N1 (P<0.019). There was no main effect of genotype nor was there a significant multivariate interaction between genotype and drug condition. Conclusion: These findings are partially consistent with the literature about sleep in depression, notably short REM latency, higher percentage of total sleep time spent in REM, lower percentage of time asleep spent in stage N3, and increased sleep fragmentation. The C/G mutation in the serotonin-1A receptor promoter region does not appear to cause noticeable differences in the sleep patterns of a relatively small sample of healthy young females. Future studies with larger sample sizes are required. Keywords: depression, sleep, serotonin, acetylcholine, buspirone, galantamineBiard KDouglass ABRobillard RDe Koninck JDove Medical PressarticleDepressionSleepSerotoninAcetylcholineBuspironeGalantaminePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol 2016, Iss Issue 1, Pp 1-8 (2015)
institution DOAJ
collection DOAJ
language EN
topic Depression
Sleep
Serotonin
Acetylcholine
Buspirone
Galantamine
Psychiatry
RC435-571
Neurophysiology and neuropsychology
QP351-495
spellingShingle Depression
Sleep
Serotonin
Acetylcholine
Buspirone
Galantamine
Psychiatry
RC435-571
Neurophysiology and neuropsychology
QP351-495
Biard K
Douglass AB
Robillard R
De Koninck J
A pilot study of serotonin-1A receptor genotypes and rapid eye movement sleep sensitivity to serotonergic/cholinergic imbalance in humans: a pharmacological model of depression
description Kathleen Biard,1,2 Alan B Douglass,2,3 Rébecca Robillard,2 Joseph De Koninck1,2 1School of Psychology, University of Ottawa, 2University of Ottawa Institute for Mental Health Research, 3Royal Ottawa Mental Health Center, University of Ottawa Institute for Mental Health Research, Ottawa, ON, Canada Rationale: The serotonergic and cholinergic systems are jointly involved in regulating sleep but this system is theorized to be disturbed in depressed individuals. We previously reported that cholinergic and serotonergic agents induce sleep changes partially consistent with monoamine models of sleep disturbances in depression. One potential cause of disturbed neurotransmission is genetic predisposition. The G(-1019) allele of the serotonin-1A (5-HT1A) receptor promoter region predicts an increased risk for depression compared to the wild-type C(-1019) allele. Objective: The goal of this study was to investigate how serotonin-1A receptor genotypes mediate sleep sensitivity to pharmacological probes modeling the serotonergic/cholinergic imbalance of depression. Methods: Seventeen healthy female participants homozygous for either C (n=11) or G (n=6) alleles aged 18–27 years were tested on four nonconsecutive nights. Participants were given galantamine (an anti-acetylcholinesterase), buspirone (a serotonergic agonist), both drugs together, or placebos before sleeping. Results: As reported previously, buspirone significantly increased rapid eye movement (REM) latency (P<0.001), as well as awakenings, percentage of time spent awake, and percentage of time asleep spent in stage N1 (P<0.019). Galantamine increased awakenings, percentage of time spent awake, percentage of time asleep spent in stage N1, and percentage of time asleep spent in REM, and decreased REM latency and percentage of time asleep spent in stage N3 (P<0.019). Galantamine plus buspirone given together disrupted sleep more than either drug alone, lowering sleep efficiency and percentage of time asleep spent in stage N3 and increasing awakenings, percentage of time spent awake, and percentage of time asleep spent in stage N1 (P<0.019). There was no main effect of genotype nor was there a significant multivariate interaction between genotype and drug condition. Conclusion: These findings are partially consistent with the literature about sleep in depression, notably short REM latency, higher percentage of total sleep time spent in REM, lower percentage of time asleep spent in stage N3, and increased sleep fragmentation. The C/G mutation in the serotonin-1A receptor promoter region does not appear to cause noticeable differences in the sleep patterns of a relatively small sample of healthy young females. Future studies with larger sample sizes are required. Keywords: depression, sleep, serotonin, acetylcholine, buspirone, galantamine
format article
author Biard K
Douglass AB
Robillard R
De Koninck J
author_facet Biard K
Douglass AB
Robillard R
De Koninck J
author_sort Biard K
title A pilot study of serotonin-1A receptor genotypes and rapid eye movement sleep sensitivity to serotonergic/cholinergic imbalance in humans: a pharmacological model of depression
title_short A pilot study of serotonin-1A receptor genotypes and rapid eye movement sleep sensitivity to serotonergic/cholinergic imbalance in humans: a pharmacological model of depression
title_full A pilot study of serotonin-1A receptor genotypes and rapid eye movement sleep sensitivity to serotonergic/cholinergic imbalance in humans: a pharmacological model of depression
title_fullStr A pilot study of serotonin-1A receptor genotypes and rapid eye movement sleep sensitivity to serotonergic/cholinergic imbalance in humans: a pharmacological model of depression
title_full_unstemmed A pilot study of serotonin-1A receptor genotypes and rapid eye movement sleep sensitivity to serotonergic/cholinergic imbalance in humans: a pharmacological model of depression
title_sort pilot study of serotonin-1a receptor genotypes and rapid eye movement sleep sensitivity to serotonergic/cholinergic imbalance in humans: a pharmacological model of depression
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/e6d4381410e1415e91b694e88ff6981b
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