Aluminium phosphide poisoning in mice and the procedure for its managements

Objective: Aluminium phosphide (ALP) cause cellular death by releasing of phosphorus. This material is also a household fumigant insecticide used in rice bags. It is known as “Rice tablet” in Iran. We studied ALP poisoning intensity in mice and tried to obtain antidote against that poison. Methods:...

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Autores principales:	AA Moghadam Nia, AR Firooz Jahi, Sh Javadian, N Dibavand
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2000
Materias:	aluminium phosphide phosphin hepatic complications antidote Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e6d84fcb55f3453b9dd58270070ff737
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spelling	oai:doaj.org-article:e6d84fcb55f3453b9dd58270070ff7372021-11-10T09:22:21ZAluminium phosphide poisoning in mice and the procedure for its managements1561-41072251-7170https://doaj.org/article/e6d84fcb55f3453b9dd58270070ff7372000-10-01T00:00:00Zhttp://jbums.org/article-1-2892-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Objective: Aluminium phosphide (ALP) cause cellular death by releasing of phosphorus. This material is also a household fumigant insecticide used in rice bags. It is known as “Rice tablet” in Iran. We studied ALP poisoning intensity in mice and tried to obtain antidote against that poison. Methods: We used 20-30 gr white male mice in this study. Acute and chronic (24-48 hr next) poisoning effects of the ALP (10, 20, 40 mg/kg) on the heart, lung, kidney and liver were studied by a pathologist. All of the drugs were injected IP. Then data were analyzed with statistical methods. Difference with P<0.05 between data from experimental groups at each point was considered statistically significant. Findings: The dosage of 40 mg/kg was considered as LD50 of ALP. The mice were exposed to this dosage died during 35±15 min. The pathologic reports showed that the most common changes were in the liver. The pretreatment of sodium selenite has not affected the mortality time, but it decreased the pulmonary and hepatic complications (Edema and fatty changes, P=0.028). NAC (50-100 mg/kg) also improved the hepatic complications and prevented the hepatic necrosis (P=0.0002). It also delayed the mortality latency time till 138±13 hrs (P<0.001). There was a significant delay in mortality latency time between the group-received vitamin C (500-1000 mg/kg) and the control group (250±70 min vs 46±12, P<0.0005). Conclusion: Pretreatment of sodium selenite dose not improve the mortality rate except the pathologic results, but NAC delays the mortality time and improves the hepatic complications completely. There was no considerable effect for magnesium sulfate in our study.AA Moghadam NiaAR Firooz JahiSh JavadianN DibavandBabol University of Medical Sciencesarticlealuminium phosphidephosphinhepatic complicationsantidoteMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 2, Iss 4, Pp 25-33 (2000)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	aluminium phosphide phosphin hepatic complications antidote Medicine R Medicine (General) R5-920
spellingShingle	aluminium phosphide phosphin hepatic complications antidote Medicine R Medicine (General) R5-920 AA Moghadam Nia AR Firooz Jahi Sh Javadian N Dibavand Aluminium phosphide poisoning in mice and the procedure for its managements
description	Objective: Aluminium phosphide (ALP) cause cellular death by releasing of phosphorus. This material is also a household fumigant insecticide used in rice bags. It is known as “Rice tablet” in Iran. We studied ALP poisoning intensity in mice and tried to obtain antidote against that poison. Methods: We used 20-30 gr white male mice in this study. Acute and chronic (24-48 hr next) poisoning effects of the ALP (10, 20, 40 mg/kg) on the heart, lung, kidney and liver were studied by a pathologist. All of the drugs were injected IP. Then data were analyzed with statistical methods. Difference with P<0.05 between data from experimental groups at each point was considered statistically significant. Findings: The dosage of 40 mg/kg was considered as LD50 of ALP. The mice were exposed to this dosage died during 35±15 min. The pathologic reports showed that the most common changes were in the liver. The pretreatment of sodium selenite has not affected the mortality time, but it decreased the pulmonary and hepatic complications (Edema and fatty changes, P=0.028). NAC (50-100 mg/kg) also improved the hepatic complications and prevented the hepatic necrosis (P=0.0002). It also delayed the mortality latency time till 138±13 hrs (P<0.001). There was a significant delay in mortality latency time between the group-received vitamin C (500-1000 mg/kg) and the control group (250±70 min vs 46±12, P<0.0005). Conclusion: Pretreatment of sodium selenite dose not improve the mortality rate except the pathologic results, but NAC delays the mortality time and improves the hepatic complications completely. There was no considerable effect for magnesium sulfate in our study.
format	article
author	AA Moghadam Nia AR Firooz Jahi Sh Javadian N Dibavand
author_facet	AA Moghadam Nia AR Firooz Jahi Sh Javadian N Dibavand
author_sort	AA Moghadam Nia
title	Aluminium phosphide poisoning in mice and the procedure for its managements
title_short	Aluminium phosphide poisoning in mice and the procedure for its managements
title_full	Aluminium phosphide poisoning in mice and the procedure for its managements
title_fullStr	Aluminium phosphide poisoning in mice and the procedure for its managements
title_full_unstemmed	Aluminium phosphide poisoning in mice and the procedure for its managements
title_sort	aluminium phosphide poisoning in mice and the procedure for its managements
publisher	Babol University of Medical Sciences
publishDate	2000
url	https://doaj.org/article/e6d84fcb55f3453b9dd58270070ff737
work_keys_str_mv	AT aamoghadamnia aluminiumphosphidepoisoninginmiceandtheprocedureforitsmanagements AT arfiroozjahi aluminiumphosphidepoisoninginmiceandtheprocedureforitsmanagements AT shjavadian aluminiumphosphidepoisoninginmiceandtheprocedureforitsmanagements AT ndibavand aluminiumphosphidepoisoninginmiceandtheprocedureforitsmanagements
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Aluminium phosphide poisoning in mice and the procedure for its managements

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