Activation of PKA via asymmetric allosteric coupling of structurally conserved cyclic nucleotide binding domains

Activation of PKA via asymmetric allosteric coupling of structurally conserved cyclic nucleotide binding domains

Protein kinase A (PKA) is a cyclic nucleotide dependent protein kinase. Here the authors use single molecule optical tweezers and steered molecular dynamic simulations to follow in real time and quantitatively characterize the signals transduced by cAMP through the structure of the PKA regulatory su...

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Autores principales: Yuxin Hao, Jeneffer P. England, Luca Bellucci, Emanuele Paci, H. Courtney Hodges, Susan S. Taylor, Rodrigo A. Maillard
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/e6d9e9b414f34aa48cefa8fdd15dd057
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