Heparan sulfate proteoglycans present PCSK9 to the LDL receptor

PCSK9 interacts with LDL receptor, causing its degradation, and consequently reduces the clearance of LDL. Here, Gustafsen et al. show that PCSK9 interacts with heparan sulfate proteoglycans and this binding favors LDLR degradation. Pharmacological inhibition of this binding can be exploited as ther...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Camilla Gustafsen, Ditte Olsen, Joachim Vilstrup, Signe Lund, Anika Reinhardt, Niels Wellner, Torben Larsen, Christian B. F. Andersen, Kathrin Weyer, Jin-ping Li, Peter H. Seeberger, Søren Thirup, Peder Madsen, Simon Glerup
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6df4a8d335842ca8793c25354c164bc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e6df4a8d335842ca8793c25354c164bc
record_format	dspace
spelling	oai:doaj.org-article:e6df4a8d335842ca8793c25354c164bc2021-12-02T14:42:25ZHeparan sulfate proteoglycans present PCSK9 to the LDL receptor10.1038/s41467-017-00568-72041-1723https://doaj.org/article/e6df4a8d335842ca8793c25354c164bc2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00568-7https://doaj.org/toc/2041-1723PCSK9 interacts with LDL receptor, causing its degradation, and consequently reduces the clearance of LDL. Here, Gustafsen et al. show that PCSK9 interacts with heparan sulfate proteoglycans and this binding favors LDLR degradation. Pharmacological inhibition of this binding can be exploited as therapeutic intervention to lower LDL levels.Camilla GustafsenDitte OlsenJoachim VilstrupSigne LundAnika ReinhardtNiels WellnerTorben LarsenChristian B. F. AndersenKathrin WeyerJin-ping LiPeter H. SeebergerSøren ThirupPeder MadsenSimon GlerupNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Camilla Gustafsen Ditte Olsen Joachim Vilstrup Signe Lund Anika Reinhardt Niels Wellner Torben Larsen Christian B. F. Andersen Kathrin Weyer Jin-ping Li Peter H. Seeberger Søren Thirup Peder Madsen Simon Glerup Heparan sulfate proteoglycans present PCSK9 to the LDL receptor
description	PCSK9 interacts with LDL receptor, causing its degradation, and consequently reduces the clearance of LDL. Here, Gustafsen et al. show that PCSK9 interacts with heparan sulfate proteoglycans and this binding favors LDLR degradation. Pharmacological inhibition of this binding can be exploited as therapeutic intervention to lower LDL levels.
format	article
author	Camilla Gustafsen Ditte Olsen Joachim Vilstrup Signe Lund Anika Reinhardt Niels Wellner Torben Larsen Christian B. F. Andersen Kathrin Weyer Jin-ping Li Peter H. Seeberger Søren Thirup Peder Madsen Simon Glerup
author_facet	Camilla Gustafsen Ditte Olsen Joachim Vilstrup Signe Lund Anika Reinhardt Niels Wellner Torben Larsen Christian B. F. Andersen Kathrin Weyer Jin-ping Li Peter H. Seeberger Søren Thirup Peder Madsen Simon Glerup
author_sort	Camilla Gustafsen
title	Heparan sulfate proteoglycans present PCSK9 to the LDL receptor
title_short	Heparan sulfate proteoglycans present PCSK9 to the LDL receptor
title_full	Heparan sulfate proteoglycans present PCSK9 to the LDL receptor
title_fullStr	Heparan sulfate proteoglycans present PCSK9 to the LDL receptor
title_full_unstemmed	Heparan sulfate proteoglycans present PCSK9 to the LDL receptor
title_sort	heparan sulfate proteoglycans present pcsk9 to the ldl receptor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e6df4a8d335842ca8793c25354c164bc
work_keys_str_mv	AT camillagustafsen heparansulfateproteoglycanspresentpcsk9totheldlreceptor AT ditteolsen heparansulfateproteoglycanspresentpcsk9totheldlreceptor AT joachimvilstrup heparansulfateproteoglycanspresentpcsk9totheldlreceptor AT signelund heparansulfateproteoglycanspresentpcsk9totheldlreceptor AT anikareinhardt heparansulfateproteoglycanspresentpcsk9totheldlreceptor AT nielswellner heparansulfateproteoglycanspresentpcsk9totheldlreceptor AT torbenlarsen heparansulfateproteoglycanspresentpcsk9totheldlreceptor AT christianbfandersen heparansulfateproteoglycanspresentpcsk9totheldlreceptor AT kathrinweyer heparansulfateproteoglycanspresentpcsk9totheldlreceptor AT jinpingli heparansulfateproteoglycanspresentpcsk9totheldlreceptor AT peterhseeberger heparansulfateproteoglycanspresentpcsk9totheldlreceptor AT sørenthirup heparansulfateproteoglycanspresentpcsk9totheldlreceptor AT pedermadsen heparansulfateproteoglycanspresentpcsk9totheldlreceptor AT simonglerup heparansulfateproteoglycanspresentpcsk9totheldlreceptor
_version_	1718389723185020928

Heparan sulfate proteoglycans present PCSK9 to the LDL receptor

Ejemplares similares