Cas9 immunity creates challenges for CRISPR gene editing therapies
Abstract Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 is a genome-editing technology1,2 that utilizes archaeal and bacterial Cas9 nucleases to introduce double-stranded breaks in DNA at targeted sites. These breaks can be used to remove, replace, or add pieces of DNA. Whil...
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Autores principales: | Julie M. Crudele, Jeffrey S. Chamberlain |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
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Materias: | |
Acceso en línea: | https://doaj.org/article/e6e102c06f9f4413a3b861226fafa27a |
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