Deregulation of ncRNA in Neurodegenerative Disease: Focus on circRNA, lncRNA and miRNA in Amyotrophic Lateral Sclerosis

Parallel and massive sequencing of total RNA samples derived from different samples are possible thanks to the use of NGS (Next Generation Sequencing) technologies. This allowed characterizing the transcriptomic profile of both cell and tissue populations, increasing the knowledge of the molecular p...

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Autores principales:	Paola Ruffo, Claudia Strafella, Raffaella Cascella, Valerio Caputo, Francesca Luisa Conforti, Sebastiano Andò, Emiliano Giardina
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ncRNA circRNA lncRNA miRNA amyotrophic lateral sclerosis RNA-seq Genetics QH426-470
Acceso en línea:	https://doaj.org/article/e6e342a5f7794d8589e6003eee746bd6
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spelling	oai:doaj.org-article:e6e342a5f7794d8589e6003eee746bd62021-12-02T10:08:32ZDeregulation of ncRNA in Neurodegenerative Disease: Focus on circRNA, lncRNA and miRNA in Amyotrophic Lateral Sclerosis1664-802110.3389/fgene.2021.784996https://doaj.org/article/e6e342a5f7794d8589e6003eee746bd62021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.784996/fullhttps://doaj.org/toc/1664-8021Parallel and massive sequencing of total RNA samples derived from different samples are possible thanks to the use of NGS (Next Generation Sequencing) technologies. This allowed characterizing the transcriptomic profile of both cell and tissue populations, increasing the knowledge of the molecular pathological processes of complex diseases, such as neurodegenerative diseases (NDs). Among the NDs, Amyotrophic Lateral Sclerosis (ALS) is caused by the progressive loss of motor neurons (MNs), and, to date, the diagnosis is often made by exclusion because there is no specific symptomatologic picture. For this reason, it is important to search for biomarkers that are clinically useful for carrying out a fast and accurate diagnosis of ALS. Thanks to various studies, it has been possible to propose several molecular mechanisms associated with the disease, some of which include the action of non-coding RNA, including circRNAs, miRNAs, and lncRNAs which will be discussed in the present review. The evidence analyzed in this review highlights the importance of conducting studies to better characterize the different ncRNAs in the disease to use them as possible diagnostic, prognostic, and/or predictive biomarkers of ALS and other NDs.Paola RuffoClaudia StrafellaClaudia StrafellaRaffaella CascellaRaffaella CascellaValerio CaputoValerio CaputoFrancesca Luisa ConfortiSebastiano AndòSebastiano AndòEmiliano GiardinaEmiliano GiardinaFrontiers Media S.A.articlencRNAcircRNAlncRNAmiRNAamyotrophic lateral sclerosisRNA-seqGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ncRNA circRNA lncRNA miRNA amyotrophic lateral sclerosis RNA-seq Genetics QH426-470
spellingShingle	ncRNA circRNA lncRNA miRNA amyotrophic lateral sclerosis RNA-seq Genetics QH426-470 Paola Ruffo Claudia Strafella Claudia Strafella Raffaella Cascella Raffaella Cascella Valerio Caputo Valerio Caputo Francesca Luisa Conforti Sebastiano Andò Sebastiano Andò Emiliano Giardina Emiliano Giardina Deregulation of ncRNA in Neurodegenerative Disease: Focus on circRNA, lncRNA and miRNA in Amyotrophic Lateral Sclerosis
description	Parallel and massive sequencing of total RNA samples derived from different samples are possible thanks to the use of NGS (Next Generation Sequencing) technologies. This allowed characterizing the transcriptomic profile of both cell and tissue populations, increasing the knowledge of the molecular pathological processes of complex diseases, such as neurodegenerative diseases (NDs). Among the NDs, Amyotrophic Lateral Sclerosis (ALS) is caused by the progressive loss of motor neurons (MNs), and, to date, the diagnosis is often made by exclusion because there is no specific symptomatologic picture. For this reason, it is important to search for biomarkers that are clinically useful for carrying out a fast and accurate diagnosis of ALS. Thanks to various studies, it has been possible to propose several molecular mechanisms associated with the disease, some of which include the action of non-coding RNA, including circRNAs, miRNAs, and lncRNAs which will be discussed in the present review. The evidence analyzed in this review highlights the importance of conducting studies to better characterize the different ncRNAs in the disease to use them as possible diagnostic, prognostic, and/or predictive biomarkers of ALS and other NDs.
format	article
author	Paola Ruffo Claudia Strafella Claudia Strafella Raffaella Cascella Raffaella Cascella Valerio Caputo Valerio Caputo Francesca Luisa Conforti Sebastiano Andò Sebastiano Andò Emiliano Giardina Emiliano Giardina
author_facet	Paola Ruffo Claudia Strafella Claudia Strafella Raffaella Cascella Raffaella Cascella Valerio Caputo Valerio Caputo Francesca Luisa Conforti Sebastiano Andò Sebastiano Andò Emiliano Giardina Emiliano Giardina
author_sort	Paola Ruffo
title	Deregulation of ncRNA in Neurodegenerative Disease: Focus on circRNA, lncRNA and miRNA in Amyotrophic Lateral Sclerosis
title_short	Deregulation of ncRNA in Neurodegenerative Disease: Focus on circRNA, lncRNA and miRNA in Amyotrophic Lateral Sclerosis
title_full	Deregulation of ncRNA in Neurodegenerative Disease: Focus on circRNA, lncRNA and miRNA in Amyotrophic Lateral Sclerosis
title_fullStr	Deregulation of ncRNA in Neurodegenerative Disease: Focus on circRNA, lncRNA and miRNA in Amyotrophic Lateral Sclerosis
title_full_unstemmed	Deregulation of ncRNA in Neurodegenerative Disease: Focus on circRNA, lncRNA and miRNA in Amyotrophic Lateral Sclerosis
title_sort	deregulation of ncrna in neurodegenerative disease: focus on circrna, lncrna and mirna in amyotrophic lateral sclerosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e6e342a5f7794d8589e6003eee746bd6
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Deregulation of ncRNA in Neurodegenerative Disease: Focus on circRNA, lncRNA and miRNA in Amyotrophic Lateral Sclerosis

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