A distal regulatory region of a class I human histone deacetylase

Human Histone Deacetylases (HDACs) regulate gene expression and are important drug targets. Here, the authors combine NMR measurements, enzymatic assays and molecular dynamics simulations and show that HDAC8 samples a catalytically active and an inactive state and further demonstrate that mutations...

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Autores principales:	Nicolas D. Werbeck, Vaibhav Kumar Shukla, Micha B. A. Kunze, Havva Yalinca, Ruth B. Pritchard, Lucas Siemons, Somnath Mondal, Simon O. R. Greenwood, John Kirkpatrick, Charles M. Marson, D. Flemming Hansen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6e3823b97f04066b0453b2d183e0a76
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spelling	oai:doaj.org-article:e6e3823b97f04066b0453b2d183e0a762021-12-02T16:31:04ZA distal regulatory region of a class I human histone deacetylase10.1038/s41467-020-17610-w2041-1723https://doaj.org/article/e6e3823b97f04066b0453b2d183e0a762020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17610-whttps://doaj.org/toc/2041-1723Human Histone Deacetylases (HDACs) regulate gene expression and are important drug targets. Here, the authors combine NMR measurements, enzymatic assays and molecular dynamics simulations and show that HDAC8 samples a catalytically active and an inactive state and further demonstrate that mutations and ligand binding alter the populations of the two states, which is of interest for inhibitor design.Nicolas D. WerbeckVaibhav Kumar ShuklaMicha B. A. KunzeHavva YalincaRuth B. PritchardLucas SiemonsSomnath MondalSimon O. R. GreenwoodJohn KirkpatrickCharles M. MarsonD. Flemming HansenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicolas D. Werbeck Vaibhav Kumar Shukla Micha B. A. Kunze Havva Yalinca Ruth B. Pritchard Lucas Siemons Somnath Mondal Simon O. R. Greenwood John Kirkpatrick Charles M. Marson D. Flemming Hansen A distal regulatory region of a class I human histone deacetylase
description	Human Histone Deacetylases (HDACs) regulate gene expression and are important drug targets. Here, the authors combine NMR measurements, enzymatic assays and molecular dynamics simulations and show that HDAC8 samples a catalytically active and an inactive state and further demonstrate that mutations and ligand binding alter the populations of the two states, which is of interest for inhibitor design.
format	article
author	Nicolas D. Werbeck Vaibhav Kumar Shukla Micha B. A. Kunze Havva Yalinca Ruth B. Pritchard Lucas Siemons Somnath Mondal Simon O. R. Greenwood John Kirkpatrick Charles M. Marson D. Flemming Hansen
author_facet	Nicolas D. Werbeck Vaibhav Kumar Shukla Micha B. A. Kunze Havva Yalinca Ruth B. Pritchard Lucas Siemons Somnath Mondal Simon O. R. Greenwood John Kirkpatrick Charles M. Marson D. Flemming Hansen
author_sort	Nicolas D. Werbeck
title	A distal regulatory region of a class I human histone deacetylase
title_short	A distal regulatory region of a class I human histone deacetylase
title_full	A distal regulatory region of a class I human histone deacetylase
title_fullStr	A distal regulatory region of a class I human histone deacetylase
title_full_unstemmed	A distal regulatory region of a class I human histone deacetylase
title_sort	distal regulatory region of a class i human histone deacetylase
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e6e3823b97f04066b0453b2d183e0a76
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A distal regulatory region of a class I human histone deacetylase

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