MIF is a 3’ flap nuclease that facilitates DNA replication and promotes tumor growth

Replication stress is associated with cancer formation and progression. Here the authors reveal that the macrophage migration inhibitory factor (MIF) functions as 3’ flap nuclease involved in resolving replication stress affecting overall tumor progression.

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Autores principales:	Yijie Wang, Yan Chen, Chenliang Wang, Mingming Yang, Yanan Wang, Lei Bao, Jennifer E. Wang, BongWoo Kim, Kara Y. Chan, Weizhi Xu, Emanuela Capota, Janice Ortega, Deepak Nijhawan, Guo-Min Li, Weibo Luo, Yingfei Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6e52889e32e4ede9a3a9d521e8846bc
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spelling	oai:doaj.org-article:e6e52889e32e4ede9a3a9d521e8846bc2021-12-02T16:51:13ZMIF is a 3’ flap nuclease that facilitates DNA replication and promotes tumor growth10.1038/s41467-021-23264-z2041-1723https://doaj.org/article/e6e52889e32e4ede9a3a9d521e8846bc2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23264-zhttps://doaj.org/toc/2041-1723Replication stress is associated with cancer formation and progression. Here the authors reveal that the macrophage migration inhibitory factor (MIF) functions as 3’ flap nuclease involved in resolving replication stress affecting overall tumor progression.Yijie WangYan ChenChenliang WangMingming YangYanan WangLei BaoJennifer E. WangBongWoo KimKara Y. ChanWeizhi XuEmanuela CapotaJanice OrtegaDeepak NijhawanGuo-Min LiWeibo LuoYingfei WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yijie Wang Yan Chen Chenliang Wang Mingming Yang Yanan Wang Lei Bao Jennifer E. Wang BongWoo Kim Kara Y. Chan Weizhi Xu Emanuela Capota Janice Ortega Deepak Nijhawan Guo-Min Li Weibo Luo Yingfei Wang MIF is a 3’ flap nuclease that facilitates DNA replication and promotes tumor growth
description	Replication stress is associated with cancer formation and progression. Here the authors reveal that the macrophage migration inhibitory factor (MIF) functions as 3’ flap nuclease involved in resolving replication stress affecting overall tumor progression.
format	article
author	Yijie Wang Yan Chen Chenliang Wang Mingming Yang Yanan Wang Lei Bao Jennifer E. Wang BongWoo Kim Kara Y. Chan Weizhi Xu Emanuela Capota Janice Ortega Deepak Nijhawan Guo-Min Li Weibo Luo Yingfei Wang
author_facet	Yijie Wang Yan Chen Chenliang Wang Mingming Yang Yanan Wang Lei Bao Jennifer E. Wang BongWoo Kim Kara Y. Chan Weizhi Xu Emanuela Capota Janice Ortega Deepak Nijhawan Guo-Min Li Weibo Luo Yingfei Wang
author_sort	Yijie Wang
title	MIF is a 3’ flap nuclease that facilitates DNA replication and promotes tumor growth
title_short	MIF is a 3’ flap nuclease that facilitates DNA replication and promotes tumor growth
title_full	MIF is a 3’ flap nuclease that facilitates DNA replication and promotes tumor growth
title_fullStr	MIF is a 3’ flap nuclease that facilitates DNA replication and promotes tumor growth
title_full_unstemmed	MIF is a 3’ flap nuclease that facilitates DNA replication and promotes tumor growth
title_sort	mif is a 3’ flap nuclease that facilitates dna replication and promotes tumor growth
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e6e52889e32e4ede9a3a9d521e8846bc
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MIF is a 3’ flap nuclease that facilitates DNA replication and promotes tumor growth

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