Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1

Abstract Aberrant expression of ARE-binding proteins (ARE-BPs) plays an important role in several diseases, including cancer. Both tristetraprolin (TTP) and human antigen R (HuR) are important ARE-BPs and always play opposite roles in regulating target mRNAs. Our previous work has demonstrated that...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hao Wang, Yigang Chen, Jian Guo, Ting Shan, Kaiyuan Deng, Jialin Chen, Liping Cai, Hong Zhou, Qin Zhao, Shimao Jin, Jiazeng Xia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e6e5b5b9a55a4c5dbba6a8226fc01365
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e6e5b5b9a55a4c5dbba6a8226fc01365
record_format	dspace
spelling	oai:doaj.org-article:e6e5b5b9a55a4c5dbba6a8226fc013652021-12-02T11:40:45ZDysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 110.1038/s41598-018-25443-32045-2322https://doaj.org/article/e6e5b5b9a55a4c5dbba6a8226fc013652018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25443-3https://doaj.org/toc/2045-2322Abstract Aberrant expression of ARE-binding proteins (ARE-BPs) plays an important role in several diseases, including cancer. Both tristetraprolin (TTP) and human antigen R (HuR) are important ARE-BPs and always play opposite roles in regulating target mRNAs. Our previous work has demonstrated that TTP expression is decreased in gastric cancer (GC). In this study, we reported that HuR was elevated in GC cell lines and gastric cancer patients and that decreased TTP expression partly contributed to the elevated HuR levels by regulating its mRNA turnover. We also observed that dysregulation of TTP and HuR elevated the high-mobility group box 1 (HMGB1) expression in different ways. HuR promoted HMGB1 expression at translational level, while TTP regulated HMGB1 mRNA turnover by destabilizing its mRNA. Increased HuR promoted cancer cell proliferation and the metastasis potential partly by HMGB1. Using immunohistochemistry, we observed that both positive cytoplasmic and high-expression of nuclear HuR were associated with poor pathologic features and survival of GC patients. In conclusion, this study demonstrated that dysregulation of the TTP and HuR plays an important role in GC. Moreover, high HuR nuclear expression or aberrant cytoplasmic distribution may serve as a predictor of poor survival.Hao WangYigang ChenJian GuoTing ShanKaiyuan DengJialin ChenLiping CaiHong ZhouQin ZhaoShimao JinJiazeng XiaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hao Wang Yigang Chen Jian Guo Ting Shan Kaiyuan Deng Jialin Chen Liping Cai Hong Zhou Qin Zhao Shimao Jin Jiazeng Xia Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1
description	Abstract Aberrant expression of ARE-binding proteins (ARE-BPs) plays an important role in several diseases, including cancer. Both tristetraprolin (TTP) and human antigen R (HuR) are important ARE-BPs and always play opposite roles in regulating target mRNAs. Our previous work has demonstrated that TTP expression is decreased in gastric cancer (GC). In this study, we reported that HuR was elevated in GC cell lines and gastric cancer patients and that decreased TTP expression partly contributed to the elevated HuR levels by regulating its mRNA turnover. We also observed that dysregulation of TTP and HuR elevated the high-mobility group box 1 (HMGB1) expression in different ways. HuR promoted HMGB1 expression at translational level, while TTP regulated HMGB1 mRNA turnover by destabilizing its mRNA. Increased HuR promoted cancer cell proliferation and the metastasis potential partly by HMGB1. Using immunohistochemistry, we observed that both positive cytoplasmic and high-expression of nuclear HuR were associated with poor pathologic features and survival of GC patients. In conclusion, this study demonstrated that dysregulation of the TTP and HuR plays an important role in GC. Moreover, high HuR nuclear expression or aberrant cytoplasmic distribution may serve as a predictor of poor survival.
format	article
author	Hao Wang Yigang Chen Jian Guo Ting Shan Kaiyuan Deng Jialin Chen Liping Cai Hong Zhou Qin Zhao Shimao Jin Jiazeng Xia
author_facet	Hao Wang Yigang Chen Jian Guo Ting Shan Kaiyuan Deng Jialin Chen Liping Cai Hong Zhou Qin Zhao Shimao Jin Jiazeng Xia
author_sort	Hao Wang
title	Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1
title_short	Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1
title_full	Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1
title_fullStr	Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1
title_full_unstemmed	Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1
title_sort	dysregulation of tristetraprolin and human antigen r promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e6e5b5b9a55a4c5dbba6a8226fc01365
work_keys_str_mv	AT haowang dysregulationoftristetraprolinandhumanantigenrpromotesgastriccancerprogressionspartlybyupregulationofthehighmobilitygroupbox1 AT yigangchen dysregulationoftristetraprolinandhumanantigenrpromotesgastriccancerprogressionspartlybyupregulationofthehighmobilitygroupbox1 AT jianguo dysregulationoftristetraprolinandhumanantigenrpromotesgastriccancerprogressionspartlybyupregulationofthehighmobilitygroupbox1 AT tingshan dysregulationoftristetraprolinandhumanantigenrpromotesgastriccancerprogressionspartlybyupregulationofthehighmobilitygroupbox1 AT kaiyuandeng dysregulationoftristetraprolinandhumanantigenrpromotesgastriccancerprogressionspartlybyupregulationofthehighmobilitygroupbox1 AT jialinchen dysregulationoftristetraprolinandhumanantigenrpromotesgastriccancerprogressionspartlybyupregulationofthehighmobilitygroupbox1 AT lipingcai dysregulationoftristetraprolinandhumanantigenrpromotesgastriccancerprogressionspartlybyupregulationofthehighmobilitygroupbox1 AT hongzhou dysregulationoftristetraprolinandhumanantigenrpromotesgastriccancerprogressionspartlybyupregulationofthehighmobilitygroupbox1 AT qinzhao dysregulationoftristetraprolinandhumanantigenrpromotesgastriccancerprogressionspartlybyupregulationofthehighmobilitygroupbox1 AT shimaojin dysregulationoftristetraprolinandhumanantigenrpromotesgastriccancerprogressionspartlybyupregulationofthehighmobilitygroupbox1 AT jiazengxia dysregulationoftristetraprolinandhumanantigenrpromotesgastriccancerprogressionspartlybyupregulationofthehighmobilitygroupbox1
_version_	1718395554711470080

Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1

Ejemplares similares