Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function

MG53 is a protein that regulates the cell membrane repair process, and it’s been suggested that it might play a role in diabetes. Here, the authors demonstrate that circulating MG53 functions as a myokine to facilitate tissue injury-repair and regeneration without impacting glucose handling.

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Autores principales:	Zehua Bian, Qiang Wang, Xinyu Zhou, Tao Tan, Ki Ho Park, H. Fritz Kramer, Alan McDougal, Nicholas J. Laping, Sanjay Kumar, T. M. Ayodele Adesanya, Matthew Sermersheim, Frank Yi, Xinxin Wang, Junwei Wu, Kristyn Gumpper, Qiwei Jiang, Duofen He, Pei-Hui Lin, Haichang Li, Fangxia Guan, Jingsong Zhou, Mark J. Kohr, Chunyu Zeng, Hua Zhu, Jianjie Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6e90eddc7d9412a80c0edb861c8f4a1
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spelling	oai:doaj.org-article:e6e90eddc7d9412a80c0edb861c8f4a12021-12-02T14:39:03ZSustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function10.1038/s41467-019-12483-02041-1723https://doaj.org/article/e6e90eddc7d9412a80c0edb861c8f4a12019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12483-0https://doaj.org/toc/2041-1723MG53 is a protein that regulates the cell membrane repair process, and it’s been suggested that it might play a role in diabetes. Here, the authors demonstrate that circulating MG53 functions as a myokine to facilitate tissue injury-repair and regeneration without impacting glucose handling.Zehua BianQiang WangXinyu ZhouTao TanKi Ho ParkH. Fritz KramerAlan McDougalNicholas J. LapingSanjay KumarT. M. Ayodele AdesanyaMatthew SermersheimFrank YiXinxin WangJunwei WuKristyn GumpperQiwei JiangDuofen HePei-Hui LinHaichang LiFangxia GuanJingsong ZhouMark J. KohrChunyu ZengHua ZhuJianjie MaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zehua Bian Qiang Wang Xinyu Zhou Tao Tan Ki Ho Park H. Fritz Kramer Alan McDougal Nicholas J. Laping Sanjay Kumar T. M. Ayodele Adesanya Matthew Sermersheim Frank Yi Xinxin Wang Junwei Wu Kristyn Gumpper Qiwei Jiang Duofen He Pei-Hui Lin Haichang Li Fangxia Guan Jingsong Zhou Mark J. Kohr Chunyu Zeng Hua Zhu Jianjie Ma Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function
description	MG53 is a protein that regulates the cell membrane repair process, and it’s been suggested that it might play a role in diabetes. Here, the authors demonstrate that circulating MG53 functions as a myokine to facilitate tissue injury-repair and regeneration without impacting glucose handling.
format	article
author	Zehua Bian Qiang Wang Xinyu Zhou Tao Tan Ki Ho Park H. Fritz Kramer Alan McDougal Nicholas J. Laping Sanjay Kumar T. M. Ayodele Adesanya Matthew Sermersheim Frank Yi Xinxin Wang Junwei Wu Kristyn Gumpper Qiwei Jiang Duofen He Pei-Hui Lin Haichang Li Fangxia Guan Jingsong Zhou Mark J. Kohr Chunyu Zeng Hua Zhu Jianjie Ma
author_facet	Zehua Bian Qiang Wang Xinyu Zhou Tao Tan Ki Ho Park H. Fritz Kramer Alan McDougal Nicholas J. Laping Sanjay Kumar T. M. Ayodele Adesanya Matthew Sermersheim Frank Yi Xinxin Wang Junwei Wu Kristyn Gumpper Qiwei Jiang Duofen He Pei-Hui Lin Haichang Li Fangxia Guan Jingsong Zhou Mark J. Kohr Chunyu Zeng Hua Zhu Jianjie Ma
author_sort	Zehua Bian
title	Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function
title_short	Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function
title_full	Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function
title_fullStr	Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function
title_full_unstemmed	Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function
title_sort	sustained elevation of mg53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e6e90eddc7d9412a80c0edb861c8f4a1
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Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function

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