OPTIMIZATION OF NEUROTRANSMITTERS SEPARATION UNDER HILIC CONDITIONS

This paper presents the optimization of a hydrophilic interaction chromatographic method for the separation of eleven catecholamines, indolamines and their precursors and metabolites. The studied parameters are: the organic modifier nature and percentage, the salt nature and concentration, the mobi...

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Main Authors:	RALUCA TAMPU, CATALIN TAMPU
Format:	article
Language:	EN
Published:	Alma Mater Publishing House "Vasile Alecsandri" University of Bacau 2017
Subjects:	catecholamines HILIC neurotransmitters Technology T Engineering (General). Civil engineering (General) TA1-2040
Online Access:	https://doaj.org/article/e6ea3a7f651b4741a9eba2590ae81fc5
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spelling	oai:doaj.org-article:e6ea3a7f651b4741a9eba2590ae81fc52021-12-02T19:50:29ZOPTIMIZATION OF NEUROTRANSMITTERS SEPARATION UNDER HILIC CONDITIONS10.29081/jesr.v23i1.902068-75592344-4932https://doaj.org/article/e6ea3a7f651b4741a9eba2590ae81fc52017-03-01T00:00:00Zhttp://www.jesr.ub.ro/1/article/view/90https://doaj.org/toc/2068-7559https://doaj.org/toc/2344-4932 This paper presents the optimization of a hydrophilic interaction chromatographic method for the separation of eleven catecholamines, indolamines and their precursors and metabolites. The studied parameters are: the organic modifier nature and percentage, the salt nature and concentration, the mobile phase pH and the column temperature. The best results in terms of separation were obtained using a mobile phase composed of acetonitrile and ammonium formate (150 mM pH 3) 85:15 v:v. RALUCA TAMPUCATALIN TAMPUAlma Mater Publishing House "Vasile Alecsandri" University of BacauarticlecatecholaminesHILICneurotransmittersTechnologyTEngineering (General). Civil engineering (General)TA1-2040ENJournal of Engineering Studies and Research, Vol 23, Iss 1 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	catecholamines HILIC neurotransmitters Technology T Engineering (General). Civil engineering (General) TA1-2040
spellingShingle	catecholamines HILIC neurotransmitters Technology T Engineering (General). Civil engineering (General) TA1-2040 RALUCA TAMPU CATALIN TAMPU OPTIMIZATION OF NEUROTRANSMITTERS SEPARATION UNDER HILIC CONDITIONS
description	This paper presents the optimization of a hydrophilic interaction chromatographic method for the separation of eleven catecholamines, indolamines and their precursors and metabolites. The studied parameters are: the organic modifier nature and percentage, the salt nature and concentration, the mobile phase pH and the column temperature. The best results in terms of separation were obtained using a mobile phase composed of acetonitrile and ammonium formate (150 mM pH 3) 85:15 v:v.
format	article
author	RALUCA TAMPU CATALIN TAMPU
author_facet	RALUCA TAMPU CATALIN TAMPU
author_sort	RALUCA TAMPU
title	OPTIMIZATION OF NEUROTRANSMITTERS SEPARATION UNDER HILIC CONDITIONS
title_short	OPTIMIZATION OF NEUROTRANSMITTERS SEPARATION UNDER HILIC CONDITIONS
title_full	OPTIMIZATION OF NEUROTRANSMITTERS SEPARATION UNDER HILIC CONDITIONS
title_fullStr	OPTIMIZATION OF NEUROTRANSMITTERS SEPARATION UNDER HILIC CONDITIONS
title_full_unstemmed	OPTIMIZATION OF NEUROTRANSMITTERS SEPARATION UNDER HILIC CONDITIONS
title_sort	optimization of neurotransmitters separation under hilic conditions
publisher	Alma Mater Publishing House "Vasile Alecsandri" University of Bacau
publishDate	2017
url	https://doaj.org/article/e6ea3a7f651b4741a9eba2590ae81fc5
work_keys_str_mv	AT ralucatampu optimizationofneurotransmittersseparationunderhilicconditions AT catalintampu optimizationofneurotransmittersseparationunderhilicconditions
_version_	1718375934713659392

OPTIMIZATION OF NEUROTRANSMITTERS SEPARATION UNDER HILIC CONDITIONS

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