ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism

ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism

Heart responds to increased workload by enlarging cardiomyocytes to preserve function, but in pathologies hypertrophy leads to heart failure. Here the authors show that ANGPTL2 activity in the heart is critical for determining beneficial vs. pathological hypertrophy via its effect on AKT-SERCA2a sig...

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Autores principales: Zhe Tian, Keishi Miyata, Tsuyoshi Kadomatsu, Haruki Horiguchi, Hiroyuki Fukushima, Shugo Tohyama, Yoshihiro Ujihara, Takahiro Okumura, Satoshi Yamaguchi, Jiabin Zhao, Motoyoshi Endo, Jun Morinaga, Michio Sato, Taichi Sugizaki, Shunshun Zhu, Kazutoyo Terada, Hisashi Sakaguchi, Yoshihiro Komohara, Motohiro Takeya, Naoki Takeda, Kimi Araki, Ichiro Manabe, Keiichi Fukuda, Kinya Otsu, Jun Wada, Toyoaki Murohara, Satoshi Mohri, Jun K. Yamashita, Motoaki Sano, Yuichi Oike
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Q
Acceso en línea:https://doaj.org/article/e6eb0ea23c0c43f48342a0be10a7d45b
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spelling oai:doaj.org-article:e6eb0ea23c0c43f48342a0be10a7d45b2021-12-02T14:39:52ZANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism10.1038/ncomms130162041-1723https://doaj.org/article/e6eb0ea23c0c43f48342a0be10a7d45b2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms13016https://doaj.org/toc/2041-1723Heart responds to increased workload by enlarging cardiomyocytes to preserve function, but in pathologies hypertrophy leads to heart failure. Here the authors show that ANGPTL2 activity in the heart is critical for determining beneficial vs. pathological hypertrophy via its effect on AKT-SERCA2a signaling and myocardial energy.Zhe TianKeishi MiyataTsuyoshi KadomatsuHaruki HoriguchiHiroyuki FukushimaShugo TohyamaYoshihiro UjiharaTakahiro OkumuraSatoshi YamaguchiJiabin ZhaoMotoyoshi EndoJun MorinagaMichio SatoTaichi SugizakiShunshun ZhuKazutoyo TeradaHisashi SakaguchiYoshihiro KomoharaMotohiro TakeyaNaoki TakedaKimi ArakiIchiro ManabeKeiichi FukudaKinya OtsuJun WadaToyoaki MuroharaSatoshi MohriJun K. YamashitaMotoaki SanoYuichi OikeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-19 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhe Tian
Keishi Miyata
Tsuyoshi Kadomatsu
Haruki Horiguchi
Hiroyuki Fukushima
Shugo Tohyama
Yoshihiro Ujihara
Takahiro Okumura
Satoshi Yamaguchi
Jiabin Zhao
Motoyoshi Endo
Jun Morinaga
Michio Sato
Taichi Sugizaki
Shunshun Zhu
Kazutoyo Terada
Hisashi Sakaguchi
Yoshihiro Komohara
Motohiro Takeya
Naoki Takeda
Kimi Araki
Ichiro Manabe
Keiichi Fukuda
Kinya Otsu
Jun Wada
Toyoaki Murohara
Satoshi Mohri
Jun K. Yamashita
Motoaki Sano
Yuichi Oike
ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism
description Heart responds to increased workload by enlarging cardiomyocytes to preserve function, but in pathologies hypertrophy leads to heart failure. Here the authors show that ANGPTL2 activity in the heart is critical for determining beneficial vs. pathological hypertrophy via its effect on AKT-SERCA2a signaling and myocardial energy.
format article
author Zhe Tian
Keishi Miyata
Tsuyoshi Kadomatsu
Haruki Horiguchi
Hiroyuki Fukushima
Shugo Tohyama
Yoshihiro Ujihara
Takahiro Okumura
Satoshi Yamaguchi
Jiabin Zhao
Motoyoshi Endo
Jun Morinaga
Michio Sato
Taichi Sugizaki
Shunshun Zhu
Kazutoyo Terada
Hisashi Sakaguchi
Yoshihiro Komohara
Motohiro Takeya
Naoki Takeda
Kimi Araki
Ichiro Manabe
Keiichi Fukuda
Kinya Otsu
Jun Wada
Toyoaki Murohara
Satoshi Mohri
Jun K. Yamashita
Motoaki Sano
Yuichi Oike
author_facet Zhe Tian
Keishi Miyata
Tsuyoshi Kadomatsu
Haruki Horiguchi
Hiroyuki Fukushima
Shugo Tohyama
Yoshihiro Ujihara
Takahiro Okumura
Satoshi Yamaguchi
Jiabin Zhao
Motoyoshi Endo
Jun Morinaga
Michio Sato
Taichi Sugizaki
Shunshun Zhu
Kazutoyo Terada
Hisashi Sakaguchi
Yoshihiro Komohara
Motohiro Takeya
Naoki Takeda
Kimi Araki
Ichiro Manabe
Keiichi Fukuda
Kinya Otsu
Jun Wada
Toyoaki Murohara
Satoshi Mohri
Jun K. Yamashita
Motoaki Sano
Yuichi Oike
author_sort Zhe Tian
title ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism
title_short ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism
title_full ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism
title_fullStr ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism
title_full_unstemmed ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism
title_sort angptl2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/e6eb0ea23c0c43f48342a0be10a7d45b
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