ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry

Polymorphisms in LMO1 are associated with increased susceptibility to develop neuroblastoma. Here, the authors show that LMO1 directly induces the transcription factor ASCL1, which regulates the differentiation of neurons, demonstrating that ASCL1 is part of the adrenergic neuroblastoma core regulat...

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Autores principales:	Lu Wang, Tze King Tan, Adam D. Durbin, Mark W. Zimmerman, Brian J. Abraham, Shi Hao Tan, Phuong Cao Thi Ngoc, Nina Weichert-Leahey, Koshi Akahane, Lee N. Lawton, Jo Lynne Rokita, John M. Maris, Richard A. Young, A. Thomas Look, Takaomi Sanda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6eb4888c5884e66bc019c078ad386b1
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spelling	oai:doaj.org-article:e6eb4888c5884e66bc019c078ad386b12021-12-02T14:35:30ZASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry10.1038/s41467-019-13515-52041-1723https://doaj.org/article/e6eb4888c5884e66bc019c078ad386b12019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13515-5https://doaj.org/toc/2041-1723Polymorphisms in LMO1 are associated with increased susceptibility to develop neuroblastoma. Here, the authors show that LMO1 directly induces the transcription factor ASCL1, which regulates the differentiation of neurons, demonstrating that ASCL1 is part of the adrenergic neuroblastoma core regulatory circuit.Lu WangTze King TanAdam D. DurbinMark W. ZimmermanBrian J. AbrahamShi Hao TanPhuong Cao Thi NgocNina Weichert-LeaheyKoshi AkahaneLee N. LawtonJo Lynne RokitaJohn M. MarisRichard A. YoungA. Thomas LookTakaomi SandaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lu Wang Tze King Tan Adam D. Durbin Mark W. Zimmerman Brian J. Abraham Shi Hao Tan Phuong Cao Thi Ngoc Nina Weichert-Leahey Koshi Akahane Lee N. Lawton Jo Lynne Rokita John M. Maris Richard A. Young A. Thomas Look Takaomi Sanda ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
description	Polymorphisms in LMO1 are associated with increased susceptibility to develop neuroblastoma. Here, the authors show that LMO1 directly induces the transcription factor ASCL1, which regulates the differentiation of neurons, demonstrating that ASCL1 is part of the adrenergic neuroblastoma core regulatory circuit.
format	article
author	Lu Wang Tze King Tan Adam D. Durbin Mark W. Zimmerman Brian J. Abraham Shi Hao Tan Phuong Cao Thi Ngoc Nina Weichert-Leahey Koshi Akahane Lee N. Lawton Jo Lynne Rokita John M. Maris Richard A. Young A. Thomas Look Takaomi Sanda
author_facet	Lu Wang Tze King Tan Adam D. Durbin Mark W. Zimmerman Brian J. Abraham Shi Hao Tan Phuong Cao Thi Ngoc Nina Weichert-Leahey Koshi Akahane Lee N. Lawton Jo Lynne Rokita John M. Maris Richard A. Young A. Thomas Look Takaomi Sanda
author_sort	Lu Wang
title	ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
title_short	ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
title_full	ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
title_fullStr	ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
title_full_unstemmed	ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
title_sort	ascl1 is a mycn- and lmo1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e6eb4888c5884e66bc019c078ad386b1
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ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry

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