K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression

The E3 ligase Mule has been previously reported to be essential for B cell development and function by modulating p53 ubiquitination and degradation. Here Haoet al. identify KLF4 as a novel ubiquitination target of Mule and show it controls T cell proliferation and autoimmunity.

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Autores principales:	Zhenyue Hao, Yi Sheng, Gordon S. Duncan, Wanda Y. Li, Carmen Dominguez, Jennifer Sylvester, Yu-Wen Su, Gloria H.Y. Lin, Bryan E. Snow, Dirk Brenner, Annick You-Ten, Jillian Haight, Satoshi Inoue, Andrew Wakeham, Alisha Elford, Sara Hamilton, Yi Liang, Juan C. Zúñiga-Pflücker, Housheng Hansen He, Pamela S. Ohashi, Tak W. Mak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6eb6c78746d4519b89d713cb4a6a1dc
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spelling	oai:doaj.org-article:e6eb6c78746d4519b89d713cb4a6a1dc2021-12-02T14:41:18ZK48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression10.1038/ncomms140032041-1723https://doaj.org/article/e6eb6c78746d4519b89d713cb4a6a1dc2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14003https://doaj.org/toc/2041-1723The E3 ligase Mule has been previously reported to be essential for B cell development and function by modulating p53 ubiquitination and degradation. Here Haoet al. identify KLF4 as a novel ubiquitination target of Mule and show it controls T cell proliferation and autoimmunity.Zhenyue HaoYi ShengGordon S. DuncanWanda Y. LiCarmen DominguezJennifer SylvesterYu-Wen SuGloria H.Y. LinBryan E. SnowDirk BrennerAnnick You-TenJillian HaightSatoshi InoueAndrew WakehamAlisha ElfordSara HamiltonYi LiangJuan C. Zúñiga-PflückerHousheng Hansen HePamela S. OhashiTak W. MakNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhenyue Hao Yi Sheng Gordon S. Duncan Wanda Y. Li Carmen Dominguez Jennifer Sylvester Yu-Wen Su Gloria H.Y. Lin Bryan E. Snow Dirk Brenner Annick You-Ten Jillian Haight Satoshi Inoue Andrew Wakeham Alisha Elford Sara Hamilton Yi Liang Juan C. Zúñiga-Pflücker Housheng Hansen He Pamela S. Ohashi Tak W. Mak K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression
description	The E3 ligase Mule has been previously reported to be essential for B cell development and function by modulating p53 ubiquitination and degradation. Here Haoet al. identify KLF4 as a novel ubiquitination target of Mule and show it controls T cell proliferation and autoimmunity.
format	article
author	Zhenyue Hao Yi Sheng Gordon S. Duncan Wanda Y. Li Carmen Dominguez Jennifer Sylvester Yu-Wen Su Gloria H.Y. Lin Bryan E. Snow Dirk Brenner Annick You-Ten Jillian Haight Satoshi Inoue Andrew Wakeham Alisha Elford Sara Hamilton Yi Liang Juan C. Zúñiga-Pflücker Housheng Hansen He Pamela S. Ohashi Tak W. Mak
author_facet	Zhenyue Hao Yi Sheng Gordon S. Duncan Wanda Y. Li Carmen Dominguez Jennifer Sylvester Yu-Wen Su Gloria H.Y. Lin Bryan E. Snow Dirk Brenner Annick You-Ten Jillian Haight Satoshi Inoue Andrew Wakeham Alisha Elford Sara Hamilton Yi Liang Juan C. Zúñiga-Pflücker Housheng Hansen He Pamela S. Ohashi Tak W. Mak
author_sort	Zhenyue Hao
title	K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression
title_short	K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression
title_full	K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression
title_fullStr	K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression
title_full_unstemmed	K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression
title_sort	k48-linked klf4 ubiquitination by e3 ligase mule controls t-cell proliferation and cell cycle progression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e6eb6c78746d4519b89d713cb4a6a1dc
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K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression

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