Novel and traditional lipid-related biomarkers and their combinations in predicting coronary severity

Abstract We investigated simultaneously traditional and novel lipid indices, alone or in combination, in predicting coronary severity assessed by Gensini score (GS) in 1605 non-lipid-lowering-drug-treated patients undergoing coronary angiography. Firstly, levels of triglycerides (TG), total choleste...

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Autores principales:	Sha Li, Yuan-Lin Guo, Xi Zhao, Yan Zhang, Cheng-Gang Zhu, Na-Qiong Wu, Rui-Xia Xu, Ping Qing, Ying Gao, Xiao-Lin Li, Jing Sun, Geng Liu, Qian Dong, Jian-Jun Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e6eb7f5683e644ca91ded361cda3cdff
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spelling	oai:doaj.org-article:e6eb7f5683e644ca91ded361cda3cdff2021-12-02T15:04:52ZNovel and traditional lipid-related biomarkers and their combinations in predicting coronary severity10.1038/s41598-017-00499-92045-2322https://doaj.org/article/e6eb7f5683e644ca91ded361cda3cdff2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00499-9https://doaj.org/toc/2045-2322Abstract We investigated simultaneously traditional and novel lipid indices, alone or in combination, in predicting coronary severity assessed by Gensini score (GS) in 1605 non-lipid-lowering-drug-treated patients undergoing coronary angiography. Firstly, levels of triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), non high density lipoprotein cholesterol (non-HDL-C), apolipoprotein (apo) B, lipoprotein (a) [Lp(a)], proprotein convertase subtilisin/kexin type 9 (PCSK9), apoC3, small dense LDL (sdLDL) and large HDL were increased, while HDL-C and apoA1 levels were decreased as GS status (all p for trend <0.05). However, gender stratification analyses showed similar associations between lipids and GS in men but not in women. Secondly, multiple logistic regression analyses indicated that the 12 indices were predictive for high GS (≥24) but not for low GS (1–23) compared with normal coronary (GS = 0) except for TG (neither) and apoB (both). Finally, we found that interactions between two indices with mutually exclusive composition were positively associated with GS status except for couples of TC + apoC3, apoB/PCSK9/apoC3 + sdLDL-C. Concordant elevations in the two showed the highest predictive values for high GS (all p for trend <0.05). Therefore, lipid biomarkers were associated with coronary severity and their adverse changes in combination emerged greater risks in men but not in women.Sha LiYuan-Lin GuoXi ZhaoYan ZhangCheng-Gang ZhuNa-Qiong WuRui-Xia XuPing QingYing GaoXiao-Lin LiJing SunGeng LiuQian DongJian-Jun LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sha Li Yuan-Lin Guo Xi Zhao Yan Zhang Cheng-Gang Zhu Na-Qiong Wu Rui-Xia Xu Ping Qing Ying Gao Xiao-Lin Li Jing Sun Geng Liu Qian Dong Jian-Jun Li Novel and traditional lipid-related biomarkers and their combinations in predicting coronary severity
description	Abstract We investigated simultaneously traditional and novel lipid indices, alone or in combination, in predicting coronary severity assessed by Gensini score (GS) in 1605 non-lipid-lowering-drug-treated patients undergoing coronary angiography. Firstly, levels of triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), non high density lipoprotein cholesterol (non-HDL-C), apolipoprotein (apo) B, lipoprotein (a) [Lp(a)], proprotein convertase subtilisin/kexin type 9 (PCSK9), apoC3, small dense LDL (sdLDL) and large HDL were increased, while HDL-C and apoA1 levels were decreased as GS status (all p for trend <0.05). However, gender stratification analyses showed similar associations between lipids and GS in men but not in women. Secondly, multiple logistic regression analyses indicated that the 12 indices were predictive for high GS (≥24) but not for low GS (1–23) compared with normal coronary (GS = 0) except for TG (neither) and apoB (both). Finally, we found that interactions between two indices with mutually exclusive composition were positively associated with GS status except for couples of TC + apoC3, apoB/PCSK9/apoC3 + sdLDL-C. Concordant elevations in the two showed the highest predictive values for high GS (all p for trend <0.05). Therefore, lipid biomarkers were associated with coronary severity and their adverse changes in combination emerged greater risks in men but not in women.
format	article
author	Sha Li Yuan-Lin Guo Xi Zhao Yan Zhang Cheng-Gang Zhu Na-Qiong Wu Rui-Xia Xu Ping Qing Ying Gao Xiao-Lin Li Jing Sun Geng Liu Qian Dong Jian-Jun Li
author_facet	Sha Li Yuan-Lin Guo Xi Zhao Yan Zhang Cheng-Gang Zhu Na-Qiong Wu Rui-Xia Xu Ping Qing Ying Gao Xiao-Lin Li Jing Sun Geng Liu Qian Dong Jian-Jun Li
author_sort	Sha Li
title	Novel and traditional lipid-related biomarkers and their combinations in predicting coronary severity
title_short	Novel and traditional lipid-related biomarkers and their combinations in predicting coronary severity
title_full	Novel and traditional lipid-related biomarkers and their combinations in predicting coronary severity
title_fullStr	Novel and traditional lipid-related biomarkers and their combinations in predicting coronary severity
title_full_unstemmed	Novel and traditional lipid-related biomarkers and their combinations in predicting coronary severity
title_sort	novel and traditional lipid-related biomarkers and their combinations in predicting coronary severity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e6eb7f5683e644ca91ded361cda3cdff
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Novel and traditional lipid-related biomarkers and their combinations in predicting coronary severity

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