Pho4 Is Essential for Dissemination of <named-content content-type="genus-species">Cryptococcus neoformans</named-content> to the Host Brain by Promoting Phosphate Uptake and Growth at Alkaline pH

Pho4 Is Essential for Dissemination of <named-content content-type="genus-species">Cryptococcus neoformans</named-content> to the Host Brain by Promoting Phosphate Uptake and Growth at Alkaline pH

ABSTRACT Phosphate acquisition by fungi is regulated by the phosphate-sensing and acquisition (PHO) signaling pathway. Cryptococcus neoformans disseminates from the lung to the brain and is the commonest cause of fungal meningitis worldwide. To investigate the contribution of PHO signaling to crypto...

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Bibliographic Details
Main Authors: Sophie Lev, Keren Kaufman-Francis, Desmarini Desmarini, Pierre G. Juillard, Cecilia Li, Sebastian A. Stifter, Carl G. Feng, Tania C. Sorrell, Georges E. R. Grau, Yong-Sun Bahn, Julianne T. Djordjevic
Format: article
Language:EN
Published: American Society for Microbiology 2017
Subjects:
cryptococcal meningitis
cryptococcoma
Cryptococcus neoformans
fungal pathogenesis
HLH-type transcription factor
intravenous inoculation
Microbiology
QR1-502
Online Access:https://doaj.org/article/e6ebd73772e44c50ab5233ebc0ecbd4b
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