Protection against inhalation anthrax by immunization with Salmonella enterica serovar Typhi Ty21a stably producing protective antigen of Bacillus anthracis

Counterterrorism: creating a safe, stable, easily stored anthrax vaccine A vaccine candidate for anthrax infection shows promise for improving preparedness for a biological attack. Bacillus anthracis, the bacterium responsible for anthrax is a top-tier bioterrorism agent due to its high lethality an...

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Autores principales:	B. Kim Lee Sim, Minglin Li, Manuel Osorio, Yun Wu, Tint T. Wai, Johnny W. Peterson, Eric R. James, Sumana Chakravarty, Lixin Gao, Rui Xu, Natasha KC, Richard E. Stafford, William S. Lawrence, Linsey A. Yeager, Jennifer E. Peel, Satheesh K. Sivasubramani, Ashok K. Chopra, Svetlana Filippova, Stephen L. Hoffman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e6ed55cb74e9406db34a5f3fb0bf3838
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spelling	oai:doaj.org-article:e6ed55cb74e9406db34a5f3fb0bf38382021-12-02T16:20:00ZProtection against inhalation anthrax by immunization with Salmonella enterica serovar Typhi Ty21a stably producing protective antigen of Bacillus anthracis10.1038/s41541-017-0018-42059-0105https://doaj.org/article/e6ed55cb74e9406db34a5f3fb0bf38382017-06-01T00:00:00Zhttps://doi.org/10.1038/s41541-017-0018-4https://doaj.org/toc/2059-0105Counterterrorism: creating a safe, stable, easily stored anthrax vaccine A vaccine candidate for anthrax infection shows promise for improving preparedness for a biological attack. Bacillus anthracis, the bacterium responsible for anthrax is a top-tier bioterrorism agent due to its high lethality and spore stability. The current FDA-approved anthrax vaccine and other vaccine candidates in development lack ease of preparation, have short shelf lives and adverse effects. B. Kim Lee Sim of Protein Potential LLC and her collaborators combined key B. anthracis genetic material into an existing typhoid vaccine. The vaccine vector possesses high stability, a strong safety record, and offers long-term protection after oral administration, which Sim’s group hopes to preserve in their candidate anthrax vaccine. The team showed that their hybrid vaccine conferred excellent protection in rabbits and a short vaccination regimen, and suggest further studies into its suitability for human vaccine studies.B. Kim Lee SimMinglin LiManuel OsorioYun WuTint T. WaiJohnny W. PetersonEric R. JamesSumana ChakravartyLixin GaoRui XuNatasha KCRichard E. StaffordWilliam S. LawrenceLinsey A. YeagerJennifer E. PeelSatheesh K. SivasubramaniAshok K. ChopraSvetlana FilippovaStephen L. HoffmanNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 2, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 B. Kim Lee Sim Minglin Li Manuel Osorio Yun Wu Tint T. Wai Johnny W. Peterson Eric R. James Sumana Chakravarty Lixin Gao Rui Xu Natasha KC Richard E. Stafford William S. Lawrence Linsey A. Yeager Jennifer E. Peel Satheesh K. Sivasubramani Ashok K. Chopra Svetlana Filippova Stephen L. Hoffman Protection against inhalation anthrax by immunization with Salmonella enterica serovar Typhi Ty21a stably producing protective antigen of Bacillus anthracis
description	Counterterrorism: creating a safe, stable, easily stored anthrax vaccine A vaccine candidate for anthrax infection shows promise for improving preparedness for a biological attack. Bacillus anthracis, the bacterium responsible for anthrax is a top-tier bioterrorism agent due to its high lethality and spore stability. The current FDA-approved anthrax vaccine and other vaccine candidates in development lack ease of preparation, have short shelf lives and adverse effects. B. Kim Lee Sim of Protein Potential LLC and her collaborators combined key B. anthracis genetic material into an existing typhoid vaccine. The vaccine vector possesses high stability, a strong safety record, and offers long-term protection after oral administration, which Sim’s group hopes to preserve in their candidate anthrax vaccine. The team showed that their hybrid vaccine conferred excellent protection in rabbits and a short vaccination regimen, and suggest further studies into its suitability for human vaccine studies.
format	article
author	B. Kim Lee Sim Minglin Li Manuel Osorio Yun Wu Tint T. Wai Johnny W. Peterson Eric R. James Sumana Chakravarty Lixin Gao Rui Xu Natasha KC Richard E. Stafford William S. Lawrence Linsey A. Yeager Jennifer E. Peel Satheesh K. Sivasubramani Ashok K. Chopra Svetlana Filippova Stephen L. Hoffman
author_facet	B. Kim Lee Sim Minglin Li Manuel Osorio Yun Wu Tint T. Wai Johnny W. Peterson Eric R. James Sumana Chakravarty Lixin Gao Rui Xu Natasha KC Richard E. Stafford William S. Lawrence Linsey A. Yeager Jennifer E. Peel Satheesh K. Sivasubramani Ashok K. Chopra Svetlana Filippova Stephen L. Hoffman
author_sort	B. Kim Lee Sim
title	Protection against inhalation anthrax by immunization with Salmonella enterica serovar Typhi Ty21a stably producing protective antigen of Bacillus anthracis
title_short	Protection against inhalation anthrax by immunization with Salmonella enterica serovar Typhi Ty21a stably producing protective antigen of Bacillus anthracis
title_full	Protection against inhalation anthrax by immunization with Salmonella enterica serovar Typhi Ty21a stably producing protective antigen of Bacillus anthracis
title_fullStr	Protection against inhalation anthrax by immunization with Salmonella enterica serovar Typhi Ty21a stably producing protective antigen of Bacillus anthracis
title_full_unstemmed	Protection against inhalation anthrax by immunization with Salmonella enterica serovar Typhi Ty21a stably producing protective antigen of Bacillus anthracis
title_sort	protection against inhalation anthrax by immunization with salmonella enterica serovar typhi ty21a stably producing protective antigen of bacillus anthracis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e6ed55cb74e9406db34a5f3fb0bf3838
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Protection against inhalation anthrax by immunization with Salmonella enterica serovar Typhi Ty21a stably producing protective antigen of Bacillus anthracis

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