Early socialization and environmental enrichment of lactating piglets affects the caecal microbiota and metabolomic response after weaning

Abstract The aim of this study was to determine the possible impact of early socialization and an enriched neonatal environment to improve adaptation of piglets to weaning. We hypothesized that changes in the microbiota colonization process and in their metabolic response and intestinal functionalit...

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Autores principales:	M. Saladrigas-García, M. D’Angelo, H. L. Ko, S. Traserra, P. Nolis, Y. Ramayo-Caldas, J. M. Folch, P. Vergara, P. Llonch, J. F. Pérez, S. M. Martín-Orúe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e6eeec96253a407cb06139f75ebf725b
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spelling	oai:doaj.org-article:e6eeec96253a407cb06139f75ebf725b2021-12-02T13:17:48ZEarly socialization and environmental enrichment of lactating piglets affects the caecal microbiota and metabolomic response after weaning10.1038/s41598-021-85460-72045-2322https://doaj.org/article/e6eeec96253a407cb06139f75ebf725b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85460-7https://doaj.org/toc/2045-2322Abstract The aim of this study was to determine the possible impact of early socialization and an enriched neonatal environment to improve adaptation of piglets to weaning. We hypothesized that changes in the microbiota colonization process and in their metabolic response and intestinal functionality could help the animals face weaning stress. A total of 48 sows and their litters were allotted into a control (CTR) or an enriched treatment (ENR), in which piglets from two adjacent pens were combined and enriched with toys. The pattern of caecal microbial colonization, the jejunal gene expression, the serum metabolome and the intestinal physiology of the piglets were assessed before (-2 d) and after weaning (+ 3d). A differential ordination of caecal microbiota was observed after weaning. Serum metabolome suggested a reduced energetic metabolism in ENR animals, as evidenced by shifts in triglycerides and fatty acids, VLDL/LDL and creatine regions. The TLR2 gene showed to be downregulated in the jejunum of ENR pigs after weaning. The integration of gene expression, metabolome and microbiota datasets confirmed that differences between barren and enriched neonatal environments were evident only after weaning. Our results suggest that improvements in adaptation to weaning could be mediated by a better response to the post-weaning stress.M. Saladrigas-GarcíaM. D’AngeloH. L. KoS. TraserraP. NolisY. Ramayo-CaldasJ. M. FolchP. VergaraP. LlonchJ. F. PérezS. M. Martín-OrúeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Saladrigas-García M. D’Angelo H. L. Ko S. Traserra P. Nolis Y. Ramayo-Caldas J. M. Folch P. Vergara P. Llonch J. F. Pérez S. M. Martín-Orúe Early socialization and environmental enrichment of lactating piglets affects the caecal microbiota and metabolomic response after weaning
description	Abstract The aim of this study was to determine the possible impact of early socialization and an enriched neonatal environment to improve adaptation of piglets to weaning. We hypothesized that changes in the microbiota colonization process and in their metabolic response and intestinal functionality could help the animals face weaning stress. A total of 48 sows and their litters were allotted into a control (CTR) or an enriched treatment (ENR), in which piglets from two adjacent pens were combined and enriched with toys. The pattern of caecal microbial colonization, the jejunal gene expression, the serum metabolome and the intestinal physiology of the piglets were assessed before (-2 d) and after weaning (+ 3d). A differential ordination of caecal microbiota was observed after weaning. Serum metabolome suggested a reduced energetic metabolism in ENR animals, as evidenced by shifts in triglycerides and fatty acids, VLDL/LDL and creatine regions. The TLR2 gene showed to be downregulated in the jejunum of ENR pigs after weaning. The integration of gene expression, metabolome and microbiota datasets confirmed that differences between barren and enriched neonatal environments were evident only after weaning. Our results suggest that improvements in adaptation to weaning could be mediated by a better response to the post-weaning stress.
format	article
author	M. Saladrigas-García M. D’Angelo H. L. Ko S. Traserra P. Nolis Y. Ramayo-Caldas J. M. Folch P. Vergara P. Llonch J. F. Pérez S. M. Martín-Orúe
author_facet	M. Saladrigas-García M. D’Angelo H. L. Ko S. Traserra P. Nolis Y. Ramayo-Caldas J. M. Folch P. Vergara P. Llonch J. F. Pérez S. M. Martín-Orúe
author_sort	M. Saladrigas-García
title	Early socialization and environmental enrichment of lactating piglets affects the caecal microbiota and metabolomic response after weaning
title_short	Early socialization and environmental enrichment of lactating piglets affects the caecal microbiota and metabolomic response after weaning
title_full	Early socialization and environmental enrichment of lactating piglets affects the caecal microbiota and metabolomic response after weaning
title_fullStr	Early socialization and environmental enrichment of lactating piglets affects the caecal microbiota and metabolomic response after weaning
title_full_unstemmed	Early socialization and environmental enrichment of lactating piglets affects the caecal microbiota and metabolomic response after weaning
title_sort	early socialization and environmental enrichment of lactating piglets affects the caecal microbiota and metabolomic response after weaning
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e6eeec96253a407cb06139f75ebf725b
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Early socialization and environmental enrichment of lactating piglets affects the caecal microbiota and metabolomic response after weaning

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