Repository corticotropin injection in patients with refractory psoriatic arthritis: a case series

Repository corticotropin injection in patients with refractory psoriatic arthritis: a case series

Alan N Brown Low Country Rheumatology, North Charleston, SC, USA Purpose: Although numerous treatment options are available for patients with psoriatic arthritis (PsA), a need for effective and tolerable treatments remains for patients with refractory disease who have failed previous therapies and c...

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Autor principal: Brown AN
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2016
Materias:
treatment
adrenocorticotropic hormone
psoriatic arthritis biologic failures
Diseases of the musculoskeletal system
RC925-935
Acceso en línea:https://doaj.org/article/e6efa844e4d44021acf42bfec4f54340
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spelling oai:doaj.org-article:e6efa844e4d44021acf42bfec4f543402021-12-02T02:58:39ZRepository corticotropin injection in patients with refractory psoriatic arthritis: a case series1179-156Xhttps://doaj.org/article/e6efa844e4d44021acf42bfec4f543402016-11-01T00:00:00Zhttps://www.dovepress.com/repository-corticotropin-injection-in-patients-with-refractory-psoriat-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XAlan N Brown Low Country Rheumatology, North Charleston, SC, USA Purpose: Although numerous treatment options are available for patients with psoriatic arthritis (PsA), a need for effective and tolerable treatments remains for patients with refractory disease who have failed previous therapies and continue to experience tender and/or swollen joints, pain, and disease activity. Repository corticotropin injection (RCI) is believed to produce steroidogenic, steroid-independent, anti-inflammatory, and immunomodulatory effects in patients with rheumatic disorders, such as PsA. Limited literature exists on the use of RCI in patients with refractory PsA. The objective of this case series is to provide information on the clinical features of patients with refractory PsA and their response to RCI.Patients: Nine patients treated with RCI for refractory PsA were retrospectively identified and included in the case series.Results: All the nine patients experienced at least transient improvements in their active skin and joint disease. In some patients, it was necessary to titrate the RCI to an appropriate dose. RCI was used in some patients to bridge with another PsA therapy, such as apremilast or certolizumab. RCI was well tolerated, but discontinued in three patients due to preexisting conditions (hypertension and hyperglycemia).Conclusion: RCI may be a safe and effective option for patients with refractory PsA who failed therapy with multiple previous treatments. Keywords: treatment, adrenocorticotropic hormone, psoriatic arthritis biologic failures, ­melanocortin, refractoryBrown ANDove Medical Pressarticletreatmentadrenocorticotropic hormonepsoriatic arthritis biologic failuresDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 8, Pp 97-102 (2016)
institution DOAJ
collection DOAJ
language EN
topic treatment
adrenocorticotropic hormone
psoriatic arthritis biologic failures
Diseases of the musculoskeletal system
RC925-935
spellingShingle treatment
adrenocorticotropic hormone
psoriatic arthritis biologic failures
Diseases of the musculoskeletal system
RC925-935
Brown AN
Repository corticotropin injection in patients with refractory psoriatic arthritis: a case series
description Alan N Brown Low Country Rheumatology, North Charleston, SC, USA Purpose: Although numerous treatment options are available for patients with psoriatic arthritis (PsA), a need for effective and tolerable treatments remains for patients with refractory disease who have failed previous therapies and continue to experience tender and/or swollen joints, pain, and disease activity. Repository corticotropin injection (RCI) is believed to produce steroidogenic, steroid-independent, anti-inflammatory, and immunomodulatory effects in patients with rheumatic disorders, such as PsA. Limited literature exists on the use of RCI in patients with refractory PsA. The objective of this case series is to provide information on the clinical features of patients with refractory PsA and their response to RCI.Patients: Nine patients treated with RCI for refractory PsA were retrospectively identified and included in the case series.Results: All the nine patients experienced at least transient improvements in their active skin and joint disease. In some patients, it was necessary to titrate the RCI to an appropriate dose. RCI was used in some patients to bridge with another PsA therapy, such as apremilast or certolizumab. RCI was well tolerated, but discontinued in three patients due to preexisting conditions (hypertension and hyperglycemia).Conclusion: RCI may be a safe and effective option for patients with refractory PsA who failed therapy with multiple previous treatments. Keywords: treatment, adrenocorticotropic hormone, psoriatic arthritis biologic failures, ­melanocortin, refractory
format article
author Brown AN
author_facet Brown AN
author_sort Brown AN
title Repository corticotropin injection in patients with refractory psoriatic arthritis: a case series
title_short Repository corticotropin injection in patients with refractory psoriatic arthritis: a case series
title_full Repository corticotropin injection in patients with refractory psoriatic arthritis: a case series
title_fullStr Repository corticotropin injection in patients with refractory psoriatic arthritis: a case series
title_full_unstemmed Repository corticotropin injection in patients with refractory psoriatic arthritis: a case series
title_sort repository corticotropin injection in patients with refractory psoriatic arthritis: a case series
publisher Dove Medical Press
publishDate 2016
url https://doaj.org/article/e6efa844e4d44021acf42bfec4f54340
work_keys_str_mv AT brownan repositorycorticotropininjectioninpatientswithrefractorypsoriaticarthritisacaseseries
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