Model-guided control of hippocampal discharges by local direct current stimulation

Abstract Neurostimulation is an emerging treatment for drug-resistant epilepsies when surgery is contraindicated. Recent clinical results demonstrate significant seizure frequency reduction in epileptic patients, however the mechanisms underlying this therapeutic effect are largely unknown. This stu...

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Autores principales:	Faten Mina, Julien Modolo, Fanny Recher, Gabriel Dieuset, Arnaud Biraben, Pascal Benquet, Fabrice Wendling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e6f2279404944db2899e808701ac01f9
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spelling	oai:doaj.org-article:e6f2279404944db2899e808701ac01f92021-12-02T11:52:23ZModel-guided control of hippocampal discharges by local direct current stimulation10.1038/s41598-017-01867-12045-2322https://doaj.org/article/e6f2279404944db2899e808701ac01f92017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01867-1https://doaj.org/toc/2045-2322Abstract Neurostimulation is an emerging treatment for drug-resistant epilepsies when surgery is contraindicated. Recent clinical results demonstrate significant seizure frequency reduction in epileptic patients, however the mechanisms underlying this therapeutic effect are largely unknown. This study aimed at gaining insights into local direct current stimulation (LDCS) effects on hyperexcitable tissue, by i) analyzing the impact of electrical currents locally applied on epileptogenic brain regions, and ii) characterizing currents achieving an “anti-epileptic” effect (excitability reduction). First, a neural mass model of hippocampal circuits was extended to accurately reproduce the features of hippocampal paroxysmal discharges (HPD) observed in a mouse model of epilepsy. Second, model predictions regarding current intensity and stimulation polarity were confronted to in vivo mice recordings during LDCS (n = 8). The neural mass model was able to generate realistic hippocampal discharges. Simulation of LDCS in the model pointed at a significant decrease of simulated HPD (in duration and occurrence rate, not in amplitude) for cathodal stimulation, which was successfully verified experimentally in epileptic mice. Despite the simplicity of our stimulation protocol, these results contribute to a better understanding of clinical benefits observed in epileptic patients with implanted neurostimulators. Our results also provide further support for model-guided design of neuromodulation therapy.Faten MinaJulien ModoloFanny RecherGabriel DieusetArnaud BirabenPascal BenquetFabrice WendlingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Faten Mina Julien Modolo Fanny Recher Gabriel Dieuset Arnaud Biraben Pascal Benquet Fabrice Wendling Model-guided control of hippocampal discharges by local direct current stimulation
description	Abstract Neurostimulation is an emerging treatment for drug-resistant epilepsies when surgery is contraindicated. Recent clinical results demonstrate significant seizure frequency reduction in epileptic patients, however the mechanisms underlying this therapeutic effect are largely unknown. This study aimed at gaining insights into local direct current stimulation (LDCS) effects on hyperexcitable tissue, by i) analyzing the impact of electrical currents locally applied on epileptogenic brain regions, and ii) characterizing currents achieving an “anti-epileptic” effect (excitability reduction). First, a neural mass model of hippocampal circuits was extended to accurately reproduce the features of hippocampal paroxysmal discharges (HPD) observed in a mouse model of epilepsy. Second, model predictions regarding current intensity and stimulation polarity were confronted to in vivo mice recordings during LDCS (n = 8). The neural mass model was able to generate realistic hippocampal discharges. Simulation of LDCS in the model pointed at a significant decrease of simulated HPD (in duration and occurrence rate, not in amplitude) for cathodal stimulation, which was successfully verified experimentally in epileptic mice. Despite the simplicity of our stimulation protocol, these results contribute to a better understanding of clinical benefits observed in epileptic patients with implanted neurostimulators. Our results also provide further support for model-guided design of neuromodulation therapy.
format	article
author	Faten Mina Julien Modolo Fanny Recher Gabriel Dieuset Arnaud Biraben Pascal Benquet Fabrice Wendling
author_facet	Faten Mina Julien Modolo Fanny Recher Gabriel Dieuset Arnaud Biraben Pascal Benquet Fabrice Wendling
author_sort	Faten Mina
title	Model-guided control of hippocampal discharges by local direct current stimulation
title_short	Model-guided control of hippocampal discharges by local direct current stimulation
title_full	Model-guided control of hippocampal discharges by local direct current stimulation
title_fullStr	Model-guided control of hippocampal discharges by local direct current stimulation
title_full_unstemmed	Model-guided control of hippocampal discharges by local direct current stimulation
title_sort	model-guided control of hippocampal discharges by local direct current stimulation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e6f2279404944db2899e808701ac01f9
work_keys_str_mv	AT fatenmina modelguidedcontrolofhippocampaldischargesbylocaldirectcurrentstimulation AT julienmodolo modelguidedcontrolofhippocampaldischargesbylocaldirectcurrentstimulation AT fannyrecher modelguidedcontrolofhippocampaldischargesbylocaldirectcurrentstimulation AT gabrieldieuset modelguidedcontrolofhippocampaldischargesbylocaldirectcurrentstimulation AT arnaudbiraben modelguidedcontrolofhippocampaldischargesbylocaldirectcurrentstimulation AT pascalbenquet modelguidedcontrolofhippocampaldischargesbylocaldirectcurrentstimulation AT fabricewendling modelguidedcontrolofhippocampaldischargesbylocaldirectcurrentstimulation
_version_	1718395078688374784

Model-guided control of hippocampal discharges by local direct current stimulation

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