Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force

Force-dependent formation of the talin-vinculin complex reinforces actin anchoring to focal adhesions, but how different talin-binding proteins respond to force is unclear. Here authors use an in vitro microscopy assay and show that the actomyosin force triggers the dissociation of RIAM from several...

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Autores principales:	Clémence Vigouroux, Véronique Henriot, Christophe Le Clainche
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6f4002112094dafbff45c5811349b88
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spelling	oai:doaj.org-article:e6f4002112094dafbff45c5811349b882021-12-02T16:04:34ZTalin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force10.1038/s41467-020-16922-12041-1723https://doaj.org/article/e6f4002112094dafbff45c5811349b882020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16922-1https://doaj.org/toc/2041-1723Force-dependent formation of the talin-vinculin complex reinforces actin anchoring to focal adhesions, but how different talin-binding proteins respond to force is unclear. Here authors use an in vitro microscopy assay and show that the actomyosin force triggers the dissociation of RIAM from several talin domains.Clémence VigourouxVéronique HenriotChristophe Le ClaincheNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Clémence Vigouroux Véronique Henriot Christophe Le Clainche Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force
description	Force-dependent formation of the talin-vinculin complex reinforces actin anchoring to focal adhesions, but how different talin-binding proteins respond to force is unclear. Here authors use an in vitro microscopy assay and show that the actomyosin force triggers the dissociation of RIAM from several talin domains.
format	article
author	Clémence Vigouroux Véronique Henriot Christophe Le Clainche
author_facet	Clémence Vigouroux Véronique Henriot Christophe Le Clainche
author_sort	Clémence Vigouroux
title	Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force
title_short	Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force
title_full	Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force
title_fullStr	Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force
title_full_unstemmed	Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force
title_sort	talin dissociates from riam and associates to vinculin sequentially in response to the actomyosin force
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e6f4002112094dafbff45c5811349b88
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Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force

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