Stratification and therapeutic potential of PML in metastatic breast cancer

Stratification and therapeutic potential of PML in metastatic breast cancer

Targeting PML in acute promyelocytic leukaemia has changed the outcome of patients with this disease. Here, the authors demonstrated that PML is also a potential therapeutic target in breast cancer where it specifically regulates cancer initiating cells and tumour progression through the transcripti...

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Autores principales: Natalia Martín-Martín, Marco Piva, Jelena Urosevic, Paula Aldaz, James D. Sutherland, Sonia Fernández-Ruiz, Leire Arreal, Verónica Torrano, Ana R. Cortazar, Evarist Planet, Marc Guiu, Nina Radosevic-Robin, Stephane Garcia, Iratxe Macías, Fernando Salvador, Giacomo Domenici, Oscar M. Rueda, Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Patricia Zúñiga-García, Alfredo Caro-Maldonado, Lorea Valcárcel-Jiménez, Pilar Sánchez-Mosquera, Marta Varela-Rey, Maria Luz Martínez-Chantar, Juan Anguita, Yasir H. Ibrahim, Maurizio Scaltriti, Charles H. Lawrie, Ana M. Aransay, Juan L. Iovanna, Jose Baselga, Carlos Caldas, Rosa Barrio, Violeta Serra, Maria dM Vivanco, Ander Matheu, Roger R. Gomis, Arkaitz Carracedo
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/e6f5403164b5464bb99d566e04f080ef
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spelling oai:doaj.org-article:e6f5403164b5464bb99d566e04f080ef2021-12-02T15:34:55ZStratification and therapeutic potential of PML in metastatic breast cancer10.1038/ncomms125952041-1723https://doaj.org/article/e6f5403164b5464bb99d566e04f080ef2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12595https://doaj.org/toc/2041-1723Targeting PML in acute promyelocytic leukaemia has changed the outcome of patients with this disease. Here, the authors demonstrated that PML is also a potential therapeutic target in breast cancer where it specifically regulates cancer initiating cells and tumour progression through the transcriptional regulation of SOX9.Natalia Martín-MartínMarco PivaJelena UrosevicPaula AldazJames D. SutherlandSonia Fernández-RuizLeire ArrealVerónica TorranoAna R. CortazarEvarist PlanetMarc GuiuNina Radosevic-RobinStephane GarciaIratxe MacíasFernando SalvadorGiacomo DomeniciOscar M. RuedaAmaia Zabala-LetonaAmaia Arruabarrena-AristorenaPatricia Zúñiga-GarcíaAlfredo Caro-MaldonadoLorea Valcárcel-JiménezPilar Sánchez-MosqueraMarta Varela-ReyMaria Luz Martínez-ChantarJuan AnguitaYasir H. IbrahimMaurizio ScaltritiCharles H. LawrieAna M. AransayJuan L. IovannaJose BaselgaCarlos CaldasRosa BarrioVioleta SerraMaria dM VivancoAnder MatheuRoger R. GomisArkaitz CarracedoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Natalia Martín-Martín
Marco Piva
Jelena Urosevic
Paula Aldaz
James D. Sutherland
Sonia Fernández-Ruiz
Leire Arreal
Verónica Torrano
Ana R. Cortazar
Evarist Planet
Marc Guiu
Nina Radosevic-Robin
Stephane Garcia
Iratxe Macías
Fernando Salvador
Giacomo Domenici
Oscar M. Rueda
Amaia Zabala-Letona
Amaia Arruabarrena-Aristorena
Patricia Zúñiga-García
Alfredo Caro-Maldonado
Lorea Valcárcel-Jiménez
Pilar Sánchez-Mosquera
Marta Varela-Rey
Maria Luz Martínez-Chantar
Juan Anguita
Yasir H. Ibrahim
Maurizio Scaltriti
Charles H. Lawrie
Ana M. Aransay
Juan L. Iovanna
Jose Baselga
Carlos Caldas
Rosa Barrio
Violeta Serra
Maria dM Vivanco
Ander Matheu
Roger R. Gomis
Arkaitz Carracedo
Stratification and therapeutic potential of PML in metastatic breast cancer
description Targeting PML in acute promyelocytic leukaemia has changed the outcome of patients with this disease. Here, the authors demonstrated that PML is also a potential therapeutic target in breast cancer where it specifically regulates cancer initiating cells and tumour progression through the transcriptional regulation of SOX9.
format article
author Natalia Martín-Martín
Marco Piva
Jelena Urosevic
Paula Aldaz
James D. Sutherland
Sonia Fernández-Ruiz
Leire Arreal
Verónica Torrano
Ana R. Cortazar
Evarist Planet
Marc Guiu
Nina Radosevic-Robin
Stephane Garcia
Iratxe Macías
Fernando Salvador
Giacomo Domenici
Oscar M. Rueda
Amaia Zabala-Letona
Amaia Arruabarrena-Aristorena
Patricia Zúñiga-García
Alfredo Caro-Maldonado
Lorea Valcárcel-Jiménez
Pilar Sánchez-Mosquera
Marta Varela-Rey
Maria Luz Martínez-Chantar
Juan Anguita
Yasir H. Ibrahim
Maurizio Scaltriti
Charles H. Lawrie
Ana M. Aransay
Juan L. Iovanna
Jose Baselga
Carlos Caldas
Rosa Barrio
Violeta Serra
Maria dM Vivanco
Ander Matheu
Roger R. Gomis
Arkaitz Carracedo
author_facet Natalia Martín-Martín
Marco Piva
Jelena Urosevic
Paula Aldaz
James D. Sutherland
Sonia Fernández-Ruiz
Leire Arreal
Verónica Torrano
Ana R. Cortazar
Evarist Planet
Marc Guiu
Nina Radosevic-Robin
Stephane Garcia
Iratxe Macías
Fernando Salvador
Giacomo Domenici
Oscar M. Rueda
Amaia Zabala-Letona
Amaia Arruabarrena-Aristorena
Patricia Zúñiga-García
Alfredo Caro-Maldonado
Lorea Valcárcel-Jiménez
Pilar Sánchez-Mosquera
Marta Varela-Rey
Maria Luz Martínez-Chantar
Juan Anguita
Yasir H. Ibrahim
Maurizio Scaltriti
Charles H. Lawrie
Ana M. Aransay
Juan L. Iovanna
Jose Baselga
Carlos Caldas
Rosa Barrio
Violeta Serra
Maria dM Vivanco
Ander Matheu
Roger R. Gomis
Arkaitz Carracedo
author_sort Natalia Martín-Martín
title Stratification and therapeutic potential of PML in metastatic breast cancer
title_short Stratification and therapeutic potential of PML in metastatic breast cancer
title_full Stratification and therapeutic potential of PML in metastatic breast cancer
title_fullStr Stratification and therapeutic potential of PML in metastatic breast cancer
title_full_unstemmed Stratification and therapeutic potential of PML in metastatic breast cancer
title_sort stratification and therapeutic potential of pml in metastatic breast cancer
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/e6f5403164b5464bb99d566e04f080ef
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