Free Feeding of CpG-Oligodeoxynucleotide Particles Prophylactically Attenuates Allergic Airway Inflammation and Hyperresponsiveness in Mice

CpG-oligodeoxynucleotides (CpG-ODNs) constitute an attractive alternative for asthma treatment. However, very little evidence is available from studies on the oral administration of CpG-ODNs in animals. Previously, we developed acid-resistant particles (named ODNcap) as an oral delivery device for O...

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Autores principales:	Takuma Okajima, Suguru Shigemori, Fu Namai, Tasuku Ogita, Takashi Sato, Takeshi Shimosato
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	CpG-ODNs oral delivery mouse model of allergic asthma airway inflammation airway hyperresponsiveness pulmonary vein cardiomyocytes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e6f9232b12ee4526a10083ad0fa1845b
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spelling	oai:doaj.org-article:e6f9232b12ee4526a10083ad0fa1845b2021-11-19T04:46:25ZFree Feeding of CpG-Oligodeoxynucleotide Particles Prophylactically Attenuates Allergic Airway Inflammation and Hyperresponsiveness in Mice1664-322410.3389/fimmu.2021.738041https://doaj.org/article/e6f9232b12ee4526a10083ad0fa1845b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.738041/fullhttps://doaj.org/toc/1664-3224CpG-oligodeoxynucleotides (CpG-ODNs) constitute an attractive alternative for asthma treatment. However, very little evidence is available from studies on the oral administration of CpG-ODNs in animals. Previously, we developed acid-resistant particles (named ODNcap) as an oral delivery device for ODNs. Here, we showed that free feeding of an ODNcap-containing feed prophylactically attenuates allergic airway inflammation, hyperresponsiveness, and goblet cell hyperplasia in an ovalbumin-induced asthma model. Using transcriptomics-driven approaches, we demonstrated that injury of pulmonary vein cardiomyocytes accompanies allergen inhalation challenge, but is inhibited by ODNcap feeding. We also showed the participation of an airway antimicrobial peptide (Reg3γ) and fecal microbiota in the ODNcap-mediated effects. Collectively, our findings suggest that daily oral ingestion of ODNcap may provide preventive effects on allergic bronchopulmonary insults via regulation of mechanisms involved in the gut-lung connection.Takuma OkajimaSuguru ShigemoriFu NamaiTasuku OgitaTakashi SatoTakeshi ShimosatoFrontiers Media S.A.articleCpG-ODNsoral deliverymouse model of allergic asthmaairway inflammationairway hyperresponsivenesspulmonary vein cardiomyocytesImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CpG-ODNs oral delivery mouse model of allergic asthma airway inflammation airway hyperresponsiveness pulmonary vein cardiomyocytes Immunologic diseases. Allergy RC581-607
spellingShingle	CpG-ODNs oral delivery mouse model of allergic asthma airway inflammation airway hyperresponsiveness pulmonary vein cardiomyocytes Immunologic diseases. Allergy RC581-607 Takuma Okajima Suguru Shigemori Fu Namai Tasuku Ogita Takashi Sato Takeshi Shimosato Free Feeding of CpG-Oligodeoxynucleotide Particles Prophylactically Attenuates Allergic Airway Inflammation and Hyperresponsiveness in Mice
description	CpG-oligodeoxynucleotides (CpG-ODNs) constitute an attractive alternative for asthma treatment. However, very little evidence is available from studies on the oral administration of CpG-ODNs in animals. Previously, we developed acid-resistant particles (named ODNcap) as an oral delivery device for ODNs. Here, we showed that free feeding of an ODNcap-containing feed prophylactically attenuates allergic airway inflammation, hyperresponsiveness, and goblet cell hyperplasia in an ovalbumin-induced asthma model. Using transcriptomics-driven approaches, we demonstrated that injury of pulmonary vein cardiomyocytes accompanies allergen inhalation challenge, but is inhibited by ODNcap feeding. We also showed the participation of an airway antimicrobial peptide (Reg3γ) and fecal microbiota in the ODNcap-mediated effects. Collectively, our findings suggest that daily oral ingestion of ODNcap may provide preventive effects on allergic bronchopulmonary insults via regulation of mechanisms involved in the gut-lung connection.
format	article
author	Takuma Okajima Suguru Shigemori Fu Namai Tasuku Ogita Takashi Sato Takeshi Shimosato
author_facet	Takuma Okajima Suguru Shigemori Fu Namai Tasuku Ogita Takashi Sato Takeshi Shimosato
author_sort	Takuma Okajima
title	Free Feeding of CpG-Oligodeoxynucleotide Particles Prophylactically Attenuates Allergic Airway Inflammation and Hyperresponsiveness in Mice
title_short	Free Feeding of CpG-Oligodeoxynucleotide Particles Prophylactically Attenuates Allergic Airway Inflammation and Hyperresponsiveness in Mice
title_full	Free Feeding of CpG-Oligodeoxynucleotide Particles Prophylactically Attenuates Allergic Airway Inflammation and Hyperresponsiveness in Mice
title_fullStr	Free Feeding of CpG-Oligodeoxynucleotide Particles Prophylactically Attenuates Allergic Airway Inflammation and Hyperresponsiveness in Mice
title_full_unstemmed	Free Feeding of CpG-Oligodeoxynucleotide Particles Prophylactically Attenuates Allergic Airway Inflammation and Hyperresponsiveness in Mice
title_sort	free feeding of cpg-oligodeoxynucleotide particles prophylactically attenuates allergic airway inflammation and hyperresponsiveness in mice
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e6f9232b12ee4526a10083ad0fa1845b
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Free Feeding of CpG-Oligodeoxynucleotide Particles Prophylactically Attenuates Allergic Airway Inflammation and Hyperresponsiveness in Mice

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